5NRQ
Mtb TMK crystal structure in complex with compound 33
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004798 | molecular_function | thymidylate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006227 | biological_process | dUDP biosynthetic process |
A | 0006233 | biological_process | dTDP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0046044 | biological_process | TMP metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004798 | molecular_function | thymidylate kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005525 | molecular_function | GTP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006227 | biological_process | dUDP biosynthetic process |
B | 0006233 | biological_process | dTDP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0046044 | biological_process | TMP metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue ZUI A 301 |
Chain | Residue |
A | PRO37 |
A | GLN172 |
A | HOH413 |
A | HOH445 |
A | LEU52 |
A | PHE70 |
A | ARG74 |
A | ARG95 |
A | ASN100 |
A | TYR103 |
A | ARG107 |
A | LEU171 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue CL A 302 |
Chain | Residue |
A | GLY10 |
A | ALA11 |
A | GLY12 |
A | LYS13 |
A | HOH442 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL A 303 |
Chain | Residue |
A | ARG25 |
A | SER30 |
A | VAL31 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue CL A 304 |
Chain | Residue |
A | SER142 |
A | ALA143 |
A | GLU144 |
B | ARG190 |
B | TRP191 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue ZUI B 301 |
Chain | Residue |
B | PRO37 |
B | LEU52 |
B | PHE70 |
B | ARG74 |
B | ASN100 |
B | TYR103 |
B | ARG107 |
B | ARG167 |
B | LEU171 |
B | GLN172 |
B | HOH406 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue CL B 302 |
Chain | Residue |
B | GLY10 |
B | ALA11 |
B | GLY12 |
B | LYS13 |
Functional Information from PROSITE/UniProt
site_id | PS01331 |
Number of Residues | 13 |
Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRYvaSNaAYS |
Chain | Residue | Details |
A | ILE92-SER104 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 22 |
Details | BINDING: |
Chain | Residue | Details |
A | GLY7 | |
A | TYR165 | |
A | GLU166 | |
B | GLY7 | |
B | ASP9 | |
B | TYR39 | |
B | PHE70 | |
B | ARG74 | |
B | ARG95 | |
B | ASN100 | |
B | TYR103 | |
A | ASP9 | |
B | ASP163 | |
B | TYR165 | |
B | GLU166 | |
A | TYR39 | |
A | PHE70 | |
A | ARG74 | |
A | ARG95 | |
A | ASN100 | |
A | TYR103 | |
A | ASP163 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000255 |
Chain | Residue | Details |
A | ARG153 | |
B | ARG153 |