5NRL

Structure of a pre-catalytic spliceosome

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
3	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
3	0000398	biological_process	mRNA splicing, via spliceosome
3	0000932	cellular_component	P-body
3	0003723	molecular_function	RNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005681	cellular_component	spliceosomal complex
3	0005688	cellular_component	U6 snRNP
3	0005730	cellular_component	nucleolus
3	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
3	0005737	cellular_component	cytoplasm
3	0006364	biological_process	rRNA processing
3	0006397	biological_process	mRNA processing
3	0008033	biological_process	tRNA processing
3	0008380	biological_process	RNA splicing
3	0033962	biological_process	P-body assembly
3	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
3	0071011	cellular_component	precatalytic spliceosome
3	0071013	cellular_component	catalytic step 2 spliceosome
3	0120114	cellular_component	Sm-like protein family complex
3	1990726	cellular_component	Lsm1-7-Pat1 complex
3	1990904	cellular_component	ribonucleoprotein complex
7	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
7	0000398	biological_process	mRNA splicing, via spliceosome
7	0000932	cellular_component	P-body
7	0000956	biological_process	nuclear-transcribed mRNA catabolic process
7	0003723	molecular_function	RNA binding
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005681	cellular_component	spliceosomal complex
7	0005688	cellular_component	U6 snRNP
7	0005730	cellular_component	nucleolus
7	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
7	0005737	cellular_component	cytoplasm
7	0006364	biological_process	rRNA processing
7	0006397	biological_process	mRNA processing
7	0008033	biological_process	tRNA processing
7	0008380	biological_process	RNA splicing
7	0030490	biological_process	maturation of SSU-rRNA
7	0032991	cellular_component	protein-containing complex
7	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
7	0071004	cellular_component	U2-type prespliceosome
7	0071013	cellular_component	catalytic step 2 spliceosome
7	0097526	cellular_component	spliceosomal tri-snRNP complex
7	1990726	cellular_component	Lsm1-7-Pat1 complex
7	1990904	cellular_component	ribonucleoprotein complex
8	0000398	biological_process	mRNA splicing, via spliceosome
8	0003723	molecular_function	RNA binding
8	0003729	molecular_function	mRNA binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005681	cellular_component	spliceosomal complex
8	0005688	cellular_component	U6 snRNP
8	0005730	cellular_component	nucleolus
8	0005737	cellular_component	cytoplasm
8	0006364	biological_process	rRNA processing
8	0006397	biological_process	mRNA processing
8	0008033	biological_process	tRNA processing
8	0008380	biological_process	RNA splicing
8	0032991	cellular_component	protein-containing complex
8	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
8	0071011	cellular_component	precatalytic spliceosome
8	1990904	cellular_component	ribonucleoprotein complex
a	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0000932	cellular_component	P-body
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005681	cellular_component	spliceosomal complex
a	0005688	cellular_component	U6 snRNP
a	0005730	cellular_component	nucleolus
a	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
a	0005737	cellular_component	cytoplasm
a	0006364	biological_process	rRNA processing
a	0006397	biological_process	mRNA processing
a	0008033	biological_process	tRNA processing
a	0008380	biological_process	RNA splicing
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	1990726	cellular_component	Lsm1-7-Pat1 complex
a	1990904	cellular_component	ribonucleoprotein complex
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
A	0000386	molecular_function	second spliceosomal transesterification activity
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000389	biological_process	mRNA 3'-splice site recognition
A	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
A	0000395	biological_process	mRNA 5'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000974	cellular_component	Prp19 complex
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
A	1990904	cellular_component	ribonucleoprotein complex
b	0000245	biological_process	spliceosomal complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000395	biological_process	mRNA 5'-splice site recognition
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003674	molecular_function	molecular_function
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0032991	cellular_component	protein-containing complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0070990	molecular_function	snRNP binding
b	0071004	cellular_component	U2-type prespliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990904	cellular_component	ribonucleoprotein complex
B	0000166	molecular_function	nucleotide binding
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0042802	molecular_function	identical protein binding
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0000166	molecular_function	nucleotide binding
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000974	cellular_component	Prp19 complex
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005682	cellular_component	U5 snRNP
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0000243	cellular_component	commitment complex
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000395	biological_process	mRNA 5'-splice site recognition
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0003729	molecular_function	mRNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006396	biological_process	RNA processing
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071004	cellular_component	U2-type prespliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
d	1990904	cellular_component	ribonucleoprotein complex
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0000245	biological_process	spliceosomal complex assembly
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000395	biological_process	mRNA 5'-splice site recognition
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005737	cellular_component	cytoplasm
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0032991	cellular_component	protein-containing complex
e	0034715	cellular_component	pICln-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071004	cellular_component	U2-type prespliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
e	1990935	molecular_function	splicing factor binding
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0000481	biological_process	maturation of 5S rRNA
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005681	cellular_component	spliceosomal complex
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0045292	biological_process	mRNA cis splicing, via spliceosome
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	1990904	cellular_component	ribonucleoprotein complex
f	0000245	biological_process	spliceosomal complex assembly
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000395	biological_process	mRNA 5'-splice site recognition
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005737	cellular_component	cytoplasm
f	0006397	biological_process	mRNA processing
f	0008266	molecular_function	poly(U) RNA binding
f	0008380	biological_process	RNA splicing
f	0034715	cellular_component	pICln-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0120114	cellular_component	Sm-like protein family complex
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
f	1990935	molecular_function	splicing factor binding
F	0000244	biological_process	spliceosomal tri-snRNP complex assembly
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003674	molecular_function	molecular_function
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005681	cellular_component	spliceosomal complex
F	0005687	cellular_component	U4 snRNP
F	0005739	cellular_component	mitochondrion
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071011	cellular_component	precatalytic spliceosome
F	0097526	cellular_component	spliceosomal tri-snRNP complex
F	1990904	cellular_component	ribonucleoprotein complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000395	biological_process	mRNA 5'-splice site recognition
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003674	molecular_function	molecular_function
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005737	cellular_component	cytoplasm
g	0006397	biological_process	mRNA processing
g	0008150	biological_process	biological_process
g	0008380	biological_process	RNA splicing
g	0032991	cellular_component	protein-containing complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071004	cellular_component	U2-type prespliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
G	0000245	biological_process	spliceosomal complex assembly
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003674	molecular_function	molecular_function
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005681	cellular_component	spliceosomal complex
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0000243	cellular_component	commitment complex
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000395	biological_process	mRNA 5'-splice site recognition
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0003729	molecular_function	mRNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005682	cellular_component	U5 snRNP
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0071004	cellular_component	U2-type prespliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0097525	cellular_component	spliceosomal snRNP complex
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
H	0000245	biological_process	spliceosomal complex assembly
H	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003674	molecular_function	molecular_function
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005681	cellular_component	spliceosomal complex
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0017070	molecular_function	U6 snRNA binding
H	0030621	molecular_function	U4 snRNA binding
H	0034247	biological_process	snoRNA splicing
H	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0000245	biological_process	spliceosomal complex assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000395	biological_process	mRNA 5'-splice site recognition
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0000974	cellular_component	Prp19 complex
i	0003674	molecular_function	molecular_function
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008150	biological_process	biological_process
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034715	cellular_component	pICln-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0071004	cellular_component	U2-type prespliceosome
i	0071011	cellular_component	precatalytic spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990904	cellular_component	ribonucleoprotein complex
j	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0000932	cellular_component	P-body
j	0000956	biological_process	nuclear-transcribed mRNA catabolic process
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005681	cellular_component	spliceosomal complex
j	0005688	cellular_component	U6 snRNP
j	0005730	cellular_component	nucleolus
j	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
j	0005737	cellular_component	cytoplasm
j	0006364	biological_process	rRNA processing
j	0006396	biological_process	RNA processing
j	0006397	biological_process	mRNA processing
j	0008033	biological_process	tRNA processing
j	0008380	biological_process	RNA splicing
j	0017070	molecular_function	U6 snRNA binding
j	0033962	biological_process	P-body assembly
j	0042149	biological_process	cellular response to glucose starvation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0097525	cellular_component	spliceosomal snRNP complex
j	0097526	cellular_component	spliceosomal tri-snRNP complex
j	1990726	cellular_component	Lsm1-7-Pat1 complex
j	1990904	cellular_component	ribonucleoprotein complex
J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0006396	biological_process	RNA processing
J	0006397	biological_process	mRNA processing
J	0008150	biological_process	biological_process
J	0008380	biological_process	RNA splicing
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0071001	cellular_component	U4/U6 snRNP
J	0071013	cellular_component	catalytic step 2 spliceosome
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000395	biological_process	mRNA 5'-splice site recognition
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003674	molecular_function	molecular_function
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005682	cellular_component	U5 snRNP
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005737	cellular_component	cytoplasm
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0032991	cellular_component	protein-containing complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0070990	molecular_function	snRNP binding
k	0071004	cellular_component	U2-type prespliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990904	cellular_component	ribonucleoprotein complex
K	0000245	biological_process	spliceosomal complex assembly
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000452	biological_process	snoRNA guided rRNA 2'-O-methylation
K	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0005730	cellular_component	nucleolus
K	0006364	biological_process	rRNA processing
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0030490	biological_process	maturation of SSU-rRNA
K	0030621	molecular_function	U4 snRNA binding
K	0031428	cellular_component	box C/D methylation guide snoRNP complex
K	0032040	cellular_component	small-subunit processome
K	0034511	molecular_function	U3 snoRNA binding
K	0042254	biological_process	ribosome biogenesis
K	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
K	0071011	cellular_component	precatalytic spliceosome
K	1990904	cellular_component	ribonucleoprotein complex
l	0000243	cellular_component	commitment complex
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000395	biological_process	mRNA 5'-splice site recognition
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0003729	molecular_function	mRNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005682	cellular_component	U5 snRNP
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006396	biological_process	RNA processing
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0071004	cellular_component	U2-type prespliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0097525	cellular_component	spliceosomal snRNP complex
l	0097526	cellular_component	spliceosomal tri-snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0006397	biological_process	mRNA processing
L	0008270	molecular_function	zinc ion binding
L	0008380	biological_process	RNA splicing
L	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
L	0046872	molecular_function	metal ion binding
L	1990904	cellular_component	ribonucleoprotein complex
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000395	biological_process	mRNA 5'-splice site recognition
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0000974	cellular_component	Prp19 complex
m	0003674	molecular_function	molecular_function
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008150	biological_process	biological_process
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034715	cellular_component	pICln-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0071004	cellular_component	U2-type prespliceosome
m	0071011	cellular_component	precatalytic spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
M	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0003674	molecular_function	molecular_function
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0071011	cellular_component	precatalytic spliceosome
M	1990904	cellular_component	ribonucleoprotein complex
n	0000243	cellular_component	commitment complex
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000395	biological_process	mRNA 5'-splice site recognition
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0003729	molecular_function	mRNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006396	biological_process	RNA processing
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071004	cellular_component	U2-type prespliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990904	cellular_component	ribonucleoprotein complex
N	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0003674	molecular_function	molecular_function
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0005829	cellular_component	cytosol
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
N	1990904	cellular_component	ribonucleoprotein complex
o	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0000932	cellular_component	P-body
o	0000956	biological_process	nuclear-transcribed mRNA catabolic process
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005681	cellular_component	spliceosomal complex
o	0005688	cellular_component	U6 snRNP
o	0005730	cellular_component	nucleolus
o	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
o	0005737	cellular_component	cytoplasm
o	0006364	biological_process	rRNA processing
o	0006397	biological_process	mRNA processing
o	0008033	biological_process	tRNA processing
o	0008380	biological_process	RNA splicing
o	0022613	biological_process	ribonucleoprotein complex biogenesis
o	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
o	1990726	cellular_component	Lsm1-7-Pat1 complex
o	1990904	cellular_component	ribonucleoprotein complex
O	0000245	biological_process	spliceosomal complex assembly
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0003729	molecular_function	mRNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005686	cellular_component	U2 snRNP
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0071004	cellular_component	U2-type prespliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	1903241	biological_process	U2-type prespliceosome assembly
p	0000245	biological_process	spliceosomal complex assembly
p	0000387	biological_process	spliceosomal snRNP assembly
p	0000395	biological_process	mRNA 5'-splice site recognition
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005681	cellular_component	spliceosomal complex
p	0005682	cellular_component	U5 snRNP
p	0005685	cellular_component	U1 snRNP
p	0005686	cellular_component	U2 snRNP
p	0005687	cellular_component	U4 snRNP
p	0005737	cellular_component	cytoplasm
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0032991	cellular_component	protein-containing complex
p	0034715	cellular_component	pICln-Sm protein complex
p	0036261	biological_process	7-methylguanosine cap hypermethylation
p	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
p	0071004	cellular_component	U2-type prespliceosome
p	0071011	cellular_component	precatalytic spliceosome
p	1903241	biological_process	U2-type prespliceosome assembly
p	1990904	cellular_component	ribonucleoprotein complex
p	1990935	molecular_function	splicing factor binding
P	0000245	biological_process	spliceosomal complex assembly
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003676	molecular_function	nucleic acid binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005681	cellular_component	spliceosomal complex
P	0005686	cellular_component	U2 snRNP
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0030620	molecular_function	U2 snRNA binding
P	0071004	cellular_component	U2-type prespliceosome
P	1903241	biological_process	U2-type prespliceosome assembly
q	0000245	biological_process	spliceosomal complex assembly
q	0000387	biological_process	spliceosomal snRNP assembly
q	0000395	biological_process	mRNA 5'-splice site recognition
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005681	cellular_component	spliceosomal complex
q	0005682	cellular_component	U5 snRNP
q	0005685	cellular_component	U1 snRNP
q	0005686	cellular_component	U2 snRNP
q	0005737	cellular_component	cytoplasm
q	0006397	biological_process	mRNA processing
q	0008266	molecular_function	poly(U) RNA binding
q	0008380	biological_process	RNA splicing
q	0034715	cellular_component	pICln-Sm protein complex
q	0036261	biological_process	7-methylguanosine cap hypermethylation
q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
q	0071013	cellular_component	catalytic step 2 spliceosome
q	0120114	cellular_component	Sm-like protein family complex
q	1903241	biological_process	U2-type prespliceosome assembly
q	1990904	cellular_component	ribonucleoprotein complex
q	1990935	molecular_function	splicing factor binding
Q	0000245	biological_process	spliceosomal complex assembly
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003674	molecular_function	molecular_function
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005684	cellular_component	U2-type spliceosomal complex
Q	0005686	cellular_component	U2 snRNP
Q	0006397	biological_process	mRNA processing
Q	0071004	cellular_component	U2-type prespliceosome
Q	0071011	cellular_component	precatalytic spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
Q	1903241	biological_process	U2-type prespliceosome assembly
r	0000245	biological_process	spliceosomal complex assembly
r	0000387	biological_process	spliceosomal snRNP assembly
r	0000395	biological_process	mRNA 5'-splice site recognition
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003674	molecular_function	molecular_function
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005681	cellular_component	spliceosomal complex
r	0005682	cellular_component	U5 snRNP
r	0005685	cellular_component	U1 snRNP
r	0005686	cellular_component	U2 snRNP
r	0005687	cellular_component	U4 snRNP
r	0005737	cellular_component	cytoplasm
r	0006397	biological_process	mRNA processing
r	0008150	biological_process	biological_process
r	0008380	biological_process	RNA splicing
r	0032991	cellular_component	protein-containing complex
r	0034719	cellular_component	SMN-Sm protein complex
r	0036261	biological_process	7-methylguanosine cap hypermethylation
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0071004	cellular_component	U2-type prespliceosome
r	0071011	cellular_component	precatalytic spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
r	0097526	cellular_component	spliceosomal tri-snRNP complex
r	1903241	biological_process	U2-type prespliceosome assembly
r	1990904	cellular_component	ribonucleoprotein complex
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003676	molecular_function	nucleic acid binding
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005686	cellular_component	U2 snRNP
R	0006397	biological_process	mRNA processing
R	0071004	cellular_component	U2-type prespliceosome
R	1903241	biological_process	U2-type prespliceosome assembly
s	0000245	biological_process	spliceosomal complex assembly
s	0000387	biological_process	spliceosomal snRNP assembly
s	0000395	biological_process	mRNA 5'-splice site recognition
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0003674	molecular_function	molecular_function
s	0003723	molecular_function	RNA binding
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005682	cellular_component	U5 snRNP
s	0005685	cellular_component	U1 snRNP
s	0005686	cellular_component	U2 snRNP
s	0005687	cellular_component	U4 snRNP
s	0005737	cellular_component	cytoplasm
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0032991	cellular_component	protein-containing complex
s	0036261	biological_process	7-methylguanosine cap hypermethylation
s	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
s	0070990	molecular_function	snRNP binding
s	0071004	cellular_component	U2-type prespliceosome
s	0071013	cellular_component	catalytic step 2 spliceosome
s	1903241	biological_process	U2-type prespliceosome assembly
s	1990904	cellular_component	ribonucleoprotein complex
S	0000245	biological_process	spliceosomal complex assembly
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0005634	cellular_component	nucleus
S	0005681	cellular_component	spliceosomal complex
S	0005686	cellular_component	U2 snRNP
S	0006397	biological_process	mRNA processing
S	0008270	molecular_function	zinc ion binding
S	0008380	biological_process	RNA splicing
S	0009410	biological_process	response to xenobiotic stimulus
S	0071011	cellular_component	precatalytic spliceosome
S	1903241	biological_process	U2-type prespliceosome assembly
t	0000243	cellular_component	commitment complex
t	0000245	biological_process	spliceosomal complex assembly
t	0000387	biological_process	spliceosomal snRNP assembly
t	0000395	biological_process	mRNA 5'-splice site recognition
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0003723	molecular_function	RNA binding
t	0003729	molecular_function	mRNA binding
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005682	cellular_component	U5 snRNP
t	0005685	cellular_component	U1 snRNP
t	0005686	cellular_component	U2 snRNP
t	0005687	cellular_component	U4 snRNP
t	0005737	cellular_component	cytoplasm
t	0005829	cellular_component	cytosol
t	0006396	biological_process	RNA processing
t	0006397	biological_process	mRNA processing
t	0008380	biological_process	RNA splicing
t	0030532	cellular_component	small nuclear ribonucleoprotein complex
t	0034715	cellular_component	pICln-Sm protein complex
t	0034719	cellular_component	SMN-Sm protein complex
t	0036261	biological_process	7-methylguanosine cap hypermethylation
t	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
t	0071004	cellular_component	U2-type prespliceosome
t	0071011	cellular_component	precatalytic spliceosome
t	0071013	cellular_component	catalytic step 2 spliceosome
t	0097525	cellular_component	spliceosomal snRNP complex
t	0097526	cellular_component	spliceosomal tri-snRNP complex
t	1903241	biological_process	U2-type prespliceosome assembly
t	1990904	cellular_component	ribonucleoprotein complex
T	0000395	biological_process	mRNA 5'-splice site recognition
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0003676	molecular_function	nucleic acid binding
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005681	cellular_component	spliceosomal complex
T	0006397	biological_process	mRNA processing
T	0008270	molecular_function	zinc ion binding
T	0008380	biological_process	RNA splicing
T	0046872	molecular_function	metal ion binding
T	0071004	cellular_component	U2-type prespliceosome
T	1903241	biological_process	U2-type prespliceosome assembly
u	0000245	biological_process	spliceosomal complex assembly
u	0000387	biological_process	spliceosomal snRNP assembly
u	0000395	biological_process	mRNA 5'-splice site recognition
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0000974	cellular_component	Prp19 complex
u	0003674	molecular_function	molecular_function
u	0003723	molecular_function	RNA binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005681	cellular_component	spliceosomal complex
u	0005682	cellular_component	U5 snRNP
u	0005685	cellular_component	U1 snRNP
u	0005686	cellular_component	U2 snRNP
u	0005737	cellular_component	cytoplasm
u	0005829	cellular_component	cytosol
u	0006397	biological_process	mRNA processing
u	0008150	biological_process	biological_process
u	0008380	biological_process	RNA splicing
u	0030532	cellular_component	small nuclear ribonucleoprotein complex
u	0034715	cellular_component	pICln-Sm protein complex
u	0036261	biological_process	7-methylguanosine cap hypermethylation
u	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
u	0071004	cellular_component	U2-type prespliceosome
u	0071011	cellular_component	precatalytic spliceosome
u	0071013	cellular_component	catalytic step 2 spliceosome
u	1903241	biological_process	U2-type prespliceosome assembly
u	1990904	cellular_component	ribonucleoprotein complex
U	0000245	biological_process	spliceosomal complex assembly
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0003676	molecular_function	nucleic acid binding
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005681	cellular_component	spliceosomal complex
U	0005686	cellular_component	U2 snRNP
U	0006397	biological_process	mRNA processing
U	0008270	molecular_function	zinc ion binding
U	0008380	biological_process	RNA splicing
U	0046872	molecular_function	metal ion binding
U	0071004	cellular_component	U2-type prespliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
U	1903241	biological_process	U2-type prespliceosome assembly
v	0000243	cellular_component	commitment complex
v	0000245	biological_process	spliceosomal complex assembly
v	0000387	biological_process	spliceosomal snRNP assembly
v	0000395	biological_process	mRNA 5'-splice site recognition
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0003723	molecular_function	RNA binding
v	0003729	molecular_function	mRNA binding
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005681	cellular_component	spliceosomal complex
v	0005682	cellular_component	U5 snRNP
v	0005685	cellular_component	U1 snRNP
v	0005686	cellular_component	U2 snRNP
v	0005687	cellular_component	U4 snRNP
v	0005737	cellular_component	cytoplasm
v	0005829	cellular_component	cytosol
v	0006396	biological_process	RNA processing
v	0006397	biological_process	mRNA processing
v	0008380	biological_process	RNA splicing
v	0034719	cellular_component	SMN-Sm protein complex
v	0036261	biological_process	7-methylguanosine cap hypermethylation
v	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
v	0071004	cellular_component	U2-type prespliceosome
v	0071011	cellular_component	precatalytic spliceosome
v	0071013	cellular_component	catalytic step 2 spliceosome
v	0097526	cellular_component	spliceosomal tri-snRNP complex
v	1903241	biological_process	U2-type prespliceosome assembly
v	1990904	cellular_component	ribonucleoprotein complex
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005681	cellular_component	spliceosomal complex
V	0005686	cellular_component	U2 snRNP
V	0006396	biological_process	RNA processing
V	0006397	biological_process	mRNA processing
V	0008380	biological_process	RNA splicing
V	0045292	biological_process	mRNA cis splicing, via spliceosome
V	0071004	cellular_component	U2-type prespliceosome
V	0071013	cellular_component	catalytic step 2 spliceosome
V	1903241	biological_process	U2-type prespliceosome assembly
w	0000245	biological_process	spliceosomal complex assembly
w	0000387	biological_process	spliceosomal snRNP assembly
w	0000395	biological_process	mRNA 5'-splice site recognition
w	0000398	biological_process	mRNA splicing, via spliceosome
w	0003723	molecular_function	RNA binding
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005681	cellular_component	spliceosomal complex
w	0005682	cellular_component	U5 snRNP
w	0005685	cellular_component	U1 snRNP
w	0005686	cellular_component	U2 snRNP
w	0005687	cellular_component	U4 snRNP
w	0005737	cellular_component	cytoplasm
w	0006397	biological_process	mRNA processing
w	0008380	biological_process	RNA splicing
w	0032991	cellular_component	protein-containing complex
w	0034715	cellular_component	pICln-Sm protein complex
w	0036261	biological_process	7-methylguanosine cap hypermethylation
w	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
w	0071004	cellular_component	U2-type prespliceosome
w	0071011	cellular_component	precatalytic spliceosome
w	1903241	biological_process	U2-type prespliceosome assembly
w	1990904	cellular_component	ribonucleoprotein complex
w	1990935	molecular_function	splicing factor binding
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003674	molecular_function	molecular_function
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005681	cellular_component	spliceosomal complex
W	0005686	cellular_component	U2 snRNP
W	0005737	cellular_component	cytoplasm
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0030620	molecular_function	U2 snRNA binding
W	0071004	cellular_component	U2-type prespliceosome
W	1903241	biological_process	U2-type prespliceosome assembly
x	0000245	biological_process	spliceosomal complex assembly
x	0000387	biological_process	spliceosomal snRNP assembly
x	0000395	biological_process	mRNA 5'-splice site recognition
x	0000398	biological_process	mRNA splicing, via spliceosome
x	0003723	molecular_function	RNA binding
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005681	cellular_component	spliceosomal complex
x	0005682	cellular_component	U5 snRNP
x	0005685	cellular_component	U1 snRNP
x	0005686	cellular_component	U2 snRNP
x	0005737	cellular_component	cytoplasm
x	0006397	biological_process	mRNA processing
x	0008266	molecular_function	poly(U) RNA binding
x	0008380	biological_process	RNA splicing
x	0034715	cellular_component	pICln-Sm protein complex
x	0036261	biological_process	7-methylguanosine cap hypermethylation
x	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
x	0071013	cellular_component	catalytic step 2 spliceosome
x	0120114	cellular_component	Sm-like protein family complex
x	1903241	biological_process	U2-type prespliceosome assembly
x	1990904	cellular_component	ribonucleoprotein complex
x	1990935	molecular_function	splicing factor binding
X	0016172	molecular_function	antifreeze activity
X	0050825	molecular_function	ice binding
y	0000245	biological_process	spliceosomal complex assembly
y	0000387	biological_process	spliceosomal snRNP assembly
y	0000395	biological_process	mRNA 5'-splice site recognition
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0003674	molecular_function	molecular_function
y	0003723	molecular_function	RNA binding
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005681	cellular_component	spliceosomal complex
y	0005682	cellular_component	U5 snRNP
y	0005685	cellular_component	U1 snRNP
y	0005686	cellular_component	U2 snRNP
y	0005687	cellular_component	U4 snRNP
y	0005737	cellular_component	cytoplasm
y	0006397	biological_process	mRNA processing
y	0008150	biological_process	biological_process
y	0008380	biological_process	RNA splicing
y	0032991	cellular_component	protein-containing complex
y	0034719	cellular_component	SMN-Sm protein complex
y	0036261	biological_process	7-methylguanosine cap hypermethylation
y	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
y	0071004	cellular_component	U2-type prespliceosome
y	0071011	cellular_component	precatalytic spliceosome
y	0071013	cellular_component	catalytic step 2 spliceosome
y	0097526	cellular_component	spliceosomal tri-snRNP complex
y	1903241	biological_process	U2-type prespliceosome assembly
y	1990904	cellular_component	ribonucleoprotein complex
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0003676	molecular_function	nucleic acid binding
Y	0003723	molecular_function	RNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0006397	biological_process	mRNA processing
Y	0008380	biological_process	RNA splicing
Y	0030620	molecular_function	U2 snRNA binding
Y	0071004	cellular_component	U2-type prespliceosome
Y	1903241	biological_process	U2-type prespliceosome assembly
Y	1990904	cellular_component	ribonucleoprotein complex
z	0000398	biological_process	mRNA splicing, via spliceosome
z	0000932	cellular_component	P-body
z	0003723	molecular_function	RNA binding
z	0005634	cellular_component	nucleus
z	0005681	cellular_component	spliceosomal complex
z	0005688	cellular_component	U6 snRNP
z	0005730	cellular_component	nucleolus
z	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
z	0005737	cellular_component	cytoplasm
z	0006364	biological_process	rRNA processing
z	0006397	biological_process	mRNA processing
z	0008033	biological_process	tRNA processing
z	0008380	biological_process	RNA splicing
z	0030490	biological_process	maturation of SSU-rRNA
z	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
z	0120114	cellular_component	Sm-like protein family complex
z	1990904	cellular_component	ribonucleoprotein complex
Z	0000245	biological_process	spliceosomal complex assembly
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0003674	molecular_function	molecular_function
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005686	cellular_component	U2 snRNP
Z	0006397	biological_process	mRNA processing
Z	0008380	biological_process	RNA splicing
Z	0071011	cellular_component	precatalytic spliceosome
Z	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue GTP C 1101

Chain	Residue
C	LEU142
C	SER190
C	PRO216
C	GLY217
C	LYS269
C	SER315
C	THR316
C	LYS317
C	HIS143
C	SER144
C	GLY145
C	LYS146
C	THR147
C	SER148
C	ARG176
C	LEU189

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN L 1000

Chain	Residue
L	CYS82
L	CYS85
L	HIS98
L	HIS104

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN S 1000

Chain	Residue
S	CYS11
S	CYS46
S	CYS49
S	CYS86

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN S 1001

Chain	Residue
S	CYS23
S	CYS26
S	CYS58
S	CYS61

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN S 1002

Chain	Residue
S	CYS30
S	CYS33
S	CYS73
S	CYS76

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN T 1000

Chain	Residue
T	CYS282
T	CYS285
T	HIS298
T	HIS304

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ZN T 1001

Chain	Residue
T	CYS423
T	ILE425
T	CYS426
T	HIS440
T	HIS446

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN U 1000

Chain	Residue
U	CYS68
U	CYS71
U	HIS84
U	HIS90

---

Functional Information from PROSITE/UniProt

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVpSRvaLG

Chain	Residue	Details
K	CYS71-GLY88

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IGSAshDmTWRLWDA

Chain	Residue	Details
H	ILE280-ALA294
H	VAL322-ILE336
H	VAL364-ILE378

---

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. GINIDSLKFNELVKLM

Chain	Residue	Details
B	GLY174-MET189

---

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpf..CsrwFktssvfesHlvgkiH

Chain	Residue	Details
T	CYS282-HIS304
L	CYS82-HIS104

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	129
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	490
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	273
Details	Region: {"description":"Linker"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Region: {"description":"Important for branch point selection"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	184
Details	Domain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	203
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	310
Details	Domain: {"description":"SEC63 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	176
Details	Domain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	314
Details	Domain: {"description":"SEC63 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	Motif: {"description":"DEIH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Motif: {"description":"DDAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	207
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	121
Details	Domain: {"description":"Nop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00690","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	26
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	68
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	40
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	41
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	29
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	32
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	29
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	31
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	29
Details	Repeat: {"description":"HAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	31
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	32
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	37
Details	Repeat: {"description":"HAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	32
Details	Repeat: {"description":"HAT 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	32
Details	Repeat: {"description":"HAT 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	32
Details	Repeat: {"description":"HAT 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	32
Details	Repeat: {"description":"HAT 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	24
Details	Zinc finger: {"description":"C2H2-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	38
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	37
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	37
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	37
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	37
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	37
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	37
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	37
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	38
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	30
Details	Zinc finger: {"description":"Matrin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	31
Details	Zinc finger: {"description":"Matrin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	9
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	30
Details	Zinc finger: {"description":"Matrin-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	40
Details	Repeat: {"description":"SURP motif 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	21
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI61
Number of Residues	20
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI62
Number of Residues	21
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI63
Number of Residues	38
Details	Domain: {"description":"LRRCT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI64
Number of Residues	78
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI65
Number of Residues	290
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---