5NRB
A Native Ternary Complex of Alpha-1,3-Galactosyltransferase (a-3GalT) Supports a Conserved Reaction Mechanism for Retaining Glycosyltransferases - alpha-3GalT in complex with Co2+, UDP-Gal and lactose - a3GalT-Co2+-UDP-Gal-LAT-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016758 | molecular_function | hexosyltransferase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016758 | molecular_function | hexosyltransferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11179209","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G8O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11179209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11592969","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12011052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11179209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11592969","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12011052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1G93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12011052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 356 |
| Chain | Residue | Details |
| A | GLN247 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS280 | electrostatic stabiliser, hydrogen bond donor |
| A | TRP314 | electrostatic stabiliser, hydrogen bond donor |
| A | GLU317 | activator, covalently attached, electrostatic stabiliser, nucleofuge, nucleophile |
| A | TRP356 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 356 |
| Chain | Residue | Details |
| B | GLN247 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS280 | electrostatic stabiliser, hydrogen bond donor |
| B | TRP314 | electrostatic stabiliser, hydrogen bond donor |
| B | GLU317 | activator, covalently attached, electrostatic stabiliser, nucleofuge, nucleophile |
| B | TRP356 | electrostatic stabiliser, hydrogen bond donor |
