5NQB
Rabbit Muscle L-lactate dehydrogenase in complex with malonate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0003824 | molecular_function | catalytic activity |
C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006089 | biological_process | lactate metabolic process |
C | 0006090 | biological_process | pyruvate metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0003824 | molecular_function | catalytic activity |
D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006089 | biological_process | lactate metabolic process |
D | 0006090 | biological_process | pyruvate metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue MLI A 401 |
Chain | Residue |
A | ARG170 |
C | HOH562 |
A | HIS185 |
A | VAL269 |
A | HOH524 |
A | HOH568 |
A | HOH581 |
A | HOH637 |
C | SER183 |
C | HIS185 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue MLI B 401 |
Chain | Residue |
B | ARG170 |
B | HIS185 |
B | VAL269 |
B | HOH529 |
B | HOH572 |
B | HOH589 |
B | HOH602 |
B | HOH638 |
D | SER183 |
D | HIS185 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue MLI B 402 |
Chain | Residue |
B | ASN137 |
B | LEU164 |
B | ARG168 |
B | HIS192 |
B | HOH513 |
B | HOH527 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue MLI C 401 |
Chain | Residue |
A | SER183 |
A | HIS185 |
C | ARG170 |
C | HIS185 |
C | VAL269 |
C | HOH526 |
C | HOH554 |
C | HOH584 |
C | HOH629 |
C | HOH631 |
C | HOH698 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue MLI C 402 |
Chain | Residue |
C | GLN99 |
C | ARG105 |
C | ASN137 |
C | ARG168 |
C | HIS192 |
C | THR247 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue MLI D 401 |
Chain | Residue |
B | SER183 |
B | HIS185 |
B | HOH575 |
D | ARG170 |
D | HIS185 |
D | VAL269 |
D | HOH544 |
D | HOH629 |
D | HOH630 |
D | HOH670 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue MLI D 402 |
Chain | Residue |
D | ASN137 |
D | ARG168 |
D | HIS192 |
D | ALA237 |
D | THR247 |
D | HOH523 |
D | HOH626 |
D | HOH653 |
Functional Information from PROSITE/UniProt
site_id | PS00064 |
Number of Residues | 7 |
Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
Chain | Residue | Details |
A | LEU189-SER195 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:19715328 |
Chain | Residue | Details |
A | HIS192 | |
B | HIS192 | |
C | HIS192 | |
D | HIS192 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: |
Chain | Residue | Details |
A | GLY28 | |
B | ASN137 | |
B | ARG168 | |
B | THR247 | |
C | GLY28 | |
C | ARG98 | |
C | ARG105 | |
C | ASN137 | |
C | ARG168 | |
C | THR247 | |
D | GLY28 | |
A | ARG98 | |
D | ARG98 | |
D | ARG105 | |
D | ASN137 | |
D | ARG168 | |
D | THR247 | |
A | ARG105 | |
A | ASN137 | |
A | ARG168 | |
A | THR247 | |
B | GLY28 | |
B | ARG98 | |
B | ARG105 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00338 |
Chain | Residue | Details |
A | ALA1 | |
B | ALA1 | |
C | ALA1 | |
D | ALA1 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151 |
Chain | Residue | Details |
A | LYS4 | |
D | LYS4 | |
D | LYS117 | |
D | LYS317 | |
A | LYS117 | |
A | LYS317 | |
B | LYS4 | |
B | LYS117 | |
B | LYS317 | |
C | LYS4 | |
C | LYS117 | |
C | LYS317 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00338 |
Chain | Residue | Details |
A | LYS13 | |
D | LYS13 | |
D | LYS80 | |
D | LYS125 | |
A | LYS80 | |
A | LYS125 | |
B | LYS13 | |
B | LYS80 | |
B | LYS125 | |
C | LYS13 | |
C | LYS80 | |
C | LYS125 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P00338 |
Chain | Residue | Details |
A | LYS56 | |
B | LYS56 | |
C | LYS56 | |
D | LYS56 |
site_id | SWS_FT_FI7 |
Number of Residues | 12 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151 |
Chain | Residue | Details |
A | LYS223 | |
D | LYS223 | |
D | LYS231 | |
D | LYS242 | |
A | LYS231 | |
A | LYS242 | |
B | LYS223 | |
B | LYS231 | |
B | LYS242 | |
C | LYS223 | |
C | LYS231 | |
C | LYS242 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06151 |
Chain | Residue | Details |
A | TYR238 | |
B | TYR238 | |
C | TYR238 | |
D | TYR238 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P04642 |
Chain | Residue | Details |
A | THR308 | |
A | THR321 | |
B | THR308 | |
B | THR321 | |
C | THR308 | |
C | THR321 | |
D | THR308 | |
D | THR321 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00338 |
Chain | Residue | Details |
A | SER309 | |
B | SER309 | |
C | SER309 | |
D | SER309 |
site_id | SWS_FT_FI11 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P00338 |
Chain | Residue | Details |
A | LYS56 | |
B | LYS56 | |
C | LYS56 | |
D | LYS56 |