5NQB
Rabbit Muscle L-lactate dehydrogenase in complex with malonate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue MLI A 401 |
| Chain | Residue |
| A | ARG170 |
| C | HOH562 |
| A | HIS185 |
| A | VAL269 |
| A | HOH524 |
| A | HOH568 |
| A | HOH581 |
| A | HOH637 |
| C | SER183 |
| C | HIS185 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue MLI B 401 |
| Chain | Residue |
| B | ARG170 |
| B | HIS185 |
| B | VAL269 |
| B | HOH529 |
| B | HOH572 |
| B | HOH589 |
| B | HOH602 |
| B | HOH638 |
| D | SER183 |
| D | HIS185 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MLI B 402 |
| Chain | Residue |
| B | ASN137 |
| B | LEU164 |
| B | ARG168 |
| B | HIS192 |
| B | HOH513 |
| B | HOH527 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue MLI C 401 |
| Chain | Residue |
| A | SER183 |
| A | HIS185 |
| C | ARG170 |
| C | HIS185 |
| C | VAL269 |
| C | HOH526 |
| C | HOH554 |
| C | HOH584 |
| C | HOH629 |
| C | HOH631 |
| C | HOH698 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MLI C 402 |
| Chain | Residue |
| C | GLN99 |
| C | ARG105 |
| C | ASN137 |
| C | ARG168 |
| C | HIS192 |
| C | THR247 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue MLI D 401 |
| Chain | Residue |
| B | SER183 |
| B | HIS185 |
| B | HOH575 |
| D | ARG170 |
| D | HIS185 |
| D | VAL269 |
| D | HOH544 |
| D | HOH629 |
| D | HOH630 |
| D | HOH670 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue MLI D 402 |
| Chain | Residue |
| D | ASN137 |
| D | ARG168 |
| D | HIS192 |
| D | ALA237 |
| D | THR247 |
| D | HOH523 |
| D | HOH626 |
| D | HOH653 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
| Chain | Residue | Details |
| A | LEU189-SER195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"19715328","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 132 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P00338","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P00338","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P00338","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P04642","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00338","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P00338","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
