5NQ0
Porcine (Sus scrofa) Major Histocompatibility Complex, class I, presenting DFEREGYSL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0002376 | biological_process | immune system process |
| B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0006955 | biological_process | immune response |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | GLY208 |
| A | SER237 |
| A | ASP239 |
| A | THR241 |
| A | GLN243 |
| A | HOH481 |
| B | ARG13 |
| B | HIS14 |
| B | HOH231 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | PRO48 |
| A | GLN54 |
| A | TRP61 |
| A | ARG132 |
| A | HOH431 |
| A | HOH453 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | TYR86 |
| A | TYR119 |
| A | ALA122 |
| A | ASP123 |
| A | ASP138 |
| A | HOH488 |
| A | HOH626 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | PRO48 |
| A | ARG49 |
| A | ALA50 |
| A | PRO51 |
| A | GLN54 |
| A | ARG132 |
| A | EDO305 |
| A | HOH413 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | ARG36 |
| A | GLU47 |
| A | PRO48 |
| A | ARG49 |
| A | ASP130 |
| A | ARG132 |
| A | EDO304 |
| A | HOH405 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | ASN128 |
| A | TRP134 |
| A | THR135 |
| A | LYS145 |
| A | HOH403 |
| A | HOH426 |
| A | HOH587 |
| B | GLU50 |
| B | GLN51 |
| B | HOH208 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 307 |
| Chain | Residue |
| A | ARG36 |
| A | ALA41 |
| A | GLU47 |
| A | GLU149 |
| A | HOH411 |
| A | HOH428 |
| A | HOH434 |
| A | HOH676 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | VAL13 |
| A | ARG22 |
| A | HOH438 |
| A | HOH476 |
| A | HOH514 |
| A | HOH518 |
| A | HOH610 |
| B | GLN35 |
| B | EDO107 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 101 |
| Chain | Residue |
| B | ILE38 |
| B | ASP39 |
| B | LYS46 |
| B | ALA49 |
| B | GLN51 |
| B | VAL66 |
| B | HOH203 |
| B | HOH212 |
| B | HOH217 |
| B | HOH247 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 102 |
| Chain | Residue |
| A | PRO51 |
| A | TRP52 |
| A | GLN54 |
| A | GLN55 |
| B | VAL85 |
| B | THR86 |
| B | ASP88 |
| B | HOH204 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 103 |
| Chain | Residue |
| B | GLN51 |
| B | SER52 |
| B | ASP53 |
| B | LEU54 |
| B | LEU64 |
| B | EDO107 |
| B | HOH246 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 104 |
| Chain | Residue |
| B | HOH303 |
| A | LEU207 |
| A | ARG235 |
| A | GLN243 |
| B | TYR11 |
| B | SER12 |
| B | HIS14 |
| B | PRO15 |
| B | HOH251 |
| B | HOH267 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 105 |
| Chain | Residue |
| B | LYS83 |
| B | HIS84 |
| B | LEU87 |
| B | LYS89 |
| B | PRO90 |
| B | HOH250 |
| B | HOH304 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 106 |
| Chain | Residue |
| A | ASN128 |
| B | ASN48 |
| B | GLU50 |
| B | HIS67 |
| B | THR68 |
| B | HOH269 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 107 |
| Chain | Residue |
| A | SO4308 |
| A | HOH654 |
| B | PRO34 |
| B | GLN35 |
| B | ILE36 |
| B | GLN51 |
| B | EDO103 |
| B | HOH290 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 108 |
| Chain | Residue |
| A | ASP120 |
| A | GLY121 |
| A | ALA122 |
| B | MET1 |
| B | VAL2 |
| B | ARG4 |
| B | HOH201 |
| B | HOH222 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 109 |
| Chain | Residue |
| A | ASP120 |
| A | HOH490 |
| B | MET1 |
| B | ALA3 |
| B | HIS32 |
| B | PRO33 |
| B | HOH201 |
| B | HOH322 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCRVKH |
| Chain | Residue | Details |
| B | TYR78-HIS84 | |
| A | TYR258-HIS264 |
