5NPZ
Porcine (Sus scrofa) Major Histocompatibility Complex, class I, presenting EFEDLTFLA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0006955 | biological_process | immune response |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | ARG36 |
| A | GLU47 |
| A | PRO48 |
| A | ARG49 |
| A | ASP130 |
| A | ARG132 |
| A | HOH521 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | THR135 |
| A | HOH429 |
| A | HOH547 |
| B | ASN47 |
| B | GLU49 |
| B | HIS66 |
| B | THR67 |
| A | ALA126 |
| A | ASN128 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue PEG A 303 |
| Chain | Residue |
| A | ARG36 |
| A | ASP38 |
| A | ALA41 |
| A | GLU47 |
| A | GLU149 |
| A | HOH420 |
| A | HOH501 |
| A | HOH548 |
| A | HOH627 |
| A | HOH668 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 101 |
| Chain | Residue |
| B | GLN50 |
| B | SER51 |
| B | ASP52 |
| B | LEU53 |
| B | LEU63 |
| B | HOH228 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 102 |
| Chain | Residue |
| A | ARG235 |
| A | GLN243 |
| B | TYR10 |
| B | SER11 |
| B | HIS13 |
| B | PRO14 |
| B | HOH247 |
| B | HOH252 |
| B | HOH280 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 103 |
| Chain | Residue |
| B | LYS41 |
| B | MET46 |
| B | PHE69 |
| B | THR70 |
| B | TYR77 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 104 |
| Chain | Residue |
| A | PRO51 |
| A | TRP52 |
| A | GLN54 |
| A | GLN55 |
| B | VAL84 |
| B | THR85 |
| B | LEU86 |
| B | ASP87 |
| B | HOH205 |
| B | HOH269 |
| B | HOH288 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 101 |
| Chain | Residue |
| A | LYS147 |
| C | LEU8 |
| C | HOH207 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCRVKH |
| Chain | Residue | Details |
| B | TYR77-HIS83 | |
| A | TYR258-HIS264 |
