5NPQ

Human N-myristoyltransferase 1 (MNT1) with Myristoyl-CoA analogue X10 bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0006499	biological_process	N-terminal protein myristoylation
B	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
B	0006499	biological_process	N-terminal protein myristoylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 501

Chain	Residue
A	PRO126
A	LYS289
A	VAL291
A	LEU478
A	TRP481
A	LYS482
A	CYS483

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 502

Chain	Residue
A	TYR423
A	VAL494
A	GLN496
A	HOH631
A	GLU244
A	PRO364

---

site_id	AC3
Number of Residues	29
Details	binding site for residue 94Q A 503

Chain	Residue
A	TYR117
A	GLN118
A	PHE119
A	TRP120
A	TYR180
A	VAL181
A	ILE245
A	ASN246
A	PHE247
A	LEU248
A	VAL250
A	ARG255
A	SER256
A	LYS257
A	ARG258
A	VAL259
A	ALA260
A	PRO261
A	ILE264
A	ILE267
A	THR268
A	ALA279
A	TYR281
A	THR282
A	LEU287
A	TYR479
A	MG504
A	HOH610
A	HOH611

---

site_id	AC4
Number of Residues	7
Details	binding site for residue MG A 504

Chain	Residue
A	LEU254
A	ARG255
A	SER256
A	LYS257
A	ARG258
A	VAL259
A	94Q503

---

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL B 501

Chain	Residue
B	PRO126
B	LYS289
B	PRO290
B	VAL291
B	LEU478
B	TRP481
B	LYS482
B	CYS483
B	HOH631

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL B 502

Chain	Residue
B	GLU244
B	PRO364
B	TRP374
B	TYR423
B	LEU493
B	VAL494
B	GLN496
B	HOH609

---

site_id	AC7
Number of Residues	28
Details	binding site for residue 94Q B 503

Chain	Residue
B	TYR117
B	GLN118
B	PHE119
B	TRP120
B	ASN179
B	TYR180
B	VAL181
B	ILE245
B	ASN246
B	PHE247
B	LEU248
B	VAL250
B	ARG255
B	SER256
B	LYS257
B	ARG258
B	VAL259
B	ALA260
B	PRO261
B	ILE264
B	ILE267
B	THR268
B	ALA279
B	TYR281
B	THR282
B	TYR479
B	MG504
B	HOH622

---

site_id	AC8
Number of Residues	5
Details	binding site for residue MG B 504

Chain	Residue
B	LEU254
B	LYS257
B	ARG258
B	VAL259
B	94Q503

---

Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK

Chain	Residue	Details
A	GLU244-LYS252

---

site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGiGDG

Chain	Residue	Details
A	LYS466-GLY472

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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