Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NOG

Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "Blocked" state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001725	cellular_component	stress fiber
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0030027	cellular_component	lamellipodium
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0044297	cellular_component	cell body
A	0048741	biological_process	skeletal muscle fiber development
A	0090131	biological_process	mesenchyme migration
B	0000166	molecular_function	nucleotide binding
B	0001725	cellular_component	stress fiber
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0044297	cellular_component	cell body
B	0048741	biological_process	skeletal muscle fiber development
B	0090131	biological_process	mesenchyme migration
C	0000166	molecular_function	nucleotide binding
C	0001725	cellular_component	stress fiber
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0044297	cellular_component	cell body
C	0048741	biological_process	skeletal muscle fiber development
C	0090131	biological_process	mesenchyme migration
D	0000166	molecular_function	nucleotide binding
D	0001725	cellular_component	stress fiber
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0044297	cellular_component	cell body
D	0048741	biological_process	skeletal muscle fiber development
D	0090131	biological_process	mesenchyme migration
E	0000166	molecular_function	nucleotide binding
E	0001725	cellular_component	stress fiber
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0030027	cellular_component	lamellipodium
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0044297	cellular_component	cell body
E	0048741	biological_process	skeletal muscle fiber development
E	0090131	biological_process	mesenchyme migration

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ADP A 401

Chain	Residue
A	SER14
A	TYR306
A	LYS336
A	MG402
A	GLY15
A	LEU16
A	LYS18
A	GLY156
A	ASP157
A	GLU214
A	GLY302
A	MET305

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	GLN137
A	ASP154
A	VAL339
A	ADP401

site_id	AC3
Number of Residues	12
Details	binding site for residue ADP B 401

Chain	Residue
B	SER14
B	GLY15
B	LEU16
B	LYS18
B	GLY156
B	ASP157
B	GLU214
B	GLY302
B	MET305
B	TYR306
B	LYS336
B	MG402

site_id	AC4
Number of Residues	3
Details	binding site for residue MG B 402

Chain	Residue
B	GLN137
B	ASP154
B	ADP401

site_id	AC5
Number of Residues	14
Details	binding site for residue ADP C 401

Chain	Residue
C	SER14
C	GLY15
C	LEU16
C	LYS18
C	GLY156
C	ASP157
C	ARG210
C	LYS213
C	GLU214
C	GLY302
C	MET305
C	TYR306
C	LYS336
C	MG402

site_id	AC6
Number of Residues	3
Details	binding site for residue MG C 402

Chain	Residue
C	GLN137
C	ASP154
C	ADP401

site_id	AC7
Number of Residues	13
Details	binding site for residue ADP D 401

Chain	Residue
D	SER14
D	GLY15
D	LEU16
D	LYS18
D	GLY156
D	ASP157
D	ARG210
D	GLU214
D	GLY302
D	MET305
D	TYR306
D	LYS336
D	MG402

site_id	AC8
Number of Residues	3
Details	binding site for residue MG D 402

Chain	Residue
D	GLN137
D	ASP154
D	ADP401

site_id	AC9
Number of Residues	15
Details	binding site for residue ADP E 401

Chain	Residue
E	SER14
E	GLY15
E	LEU16
E	LYS18
E	GLY156
E	ASP157
E	GLY182
E	LYS213
E	GLU214
E	GLY302
E	THR303
E	MET305
E	TYR306
E	LYS336
E	MG402

site_id	AD1
Number of Residues	4
Details	binding site for residue MG E 402

Chain	Residue
E	GLN137
E	ASP154
E	VAL339
E	ADP401

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"UniProtKB","id":"P68135","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P68138","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)