5NNO
Structure of TbALDH3 complexed with NAD and AN3057 aldehyde
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006081 | biological_process | aldehyde metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006081 | biological_process | aldehyde metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue NAD A 601 |
| Chain | Residue |
| A | ILE124 |
| A | TYR199 |
| A | THR200 |
| A | GLY201 |
| A | SER202 |
| A | VAL205 |
| A | GLU223 |
| A | LEU224 |
| A | GLY225 |
| A | SER259 |
| A | GLU365 |
| A | GLY125 |
| A | LEU393 |
| A | PHE433 |
| A | 92N602 |
| A | TRP127 |
| A | ASN128 |
| A | LEU133 |
| A | LYS151 |
| A | GLU154 |
| A | VAL183 |
| A | THR186 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 92N A 602 |
| Chain | Residue |
| A | MET75 |
| A | PRO79 |
| A | ASN128 |
| A | TYR129 |
| A | LEU132 |
| A | TRP249 |
| A | THR258 |
| A | SER259 |
| A | ALA426 |
| A | GLY427 |
| A | NAD601 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | binding site for residue NAD B 601 |
| Chain | Residue |
| B | ILE124 |
| B | GLY125 |
| B | THR126 |
| B | TRP127 |
| B | ASN128 |
| B | LEU133 |
| B | LYS151 |
| B | SER153 |
| B | GLU154 |
| B | THR186 |
| B | TYR199 |
| B | THR200 |
| B | GLY201 |
| B | SER202 |
| B | VAL205 |
| B | GLU223 |
| B | LEU224 |
| B | GLY225 |
| B | SER259 |
| B | GLU365 |
| B | LEU393 |
| B | PHE433 |
| B | 92N602 |
| B | HOH716 |
| B | HOH719 |
| B | HOH767 |
| B | HOH769 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue 92N B 602 |
| Chain | Residue |
| B | MET75 |
| B | PRO79 |
| B | ASN128 |
| B | TYR129 |
| B | LEU132 |
| B | THR258 |
| B | SER259 |
| B | GLY427 |
| B | NAD601 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP |
| Chain | Residue | Details |
| A | LEU222-PRO229 |
