5NKP
Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue CIT A 601 |
| Chain | Residue |
| A | SER477 |
| A | THR478 |
| A | ARG504 |
| A | SER506 |
| B | SER458 |
| B | SER477 |
| B | THR478 |
| B | ARG479 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 602 |
| Chain | Residue |
| A | ARG360 |
| A | SER385 |
| A | THR386 |
| A | ARG339 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 601 |
| Chain | Residue |
| B | ARG339 |
| B | ARG360 |
| B | SER385 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 96 |
| Details | Repeat: {"description":"Kelch 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"26435498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"26435498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA and PKC","evidences":[{"source":"PubMed","id":"25313067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26435498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27727489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30718414","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"35179207","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with KLHL3","evidences":[{"source":"PubMed","id":"35179207","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
