5NJ9
E. coli Microcin-processing metalloprotease TldD/E with DRVY angiotensin fragment bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016485 | biological_process | protein processing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 1905368 | cellular_component | peptidase complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0016485 | biological_process | protein processing |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 1905368 | cellular_component | peptidase complex |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016485 | biological_process | protein processing |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 1905368 | cellular_component | peptidase complex |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0016485 | biological_process | protein processing |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 1905368 | cellular_component | peptidase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | HIS262 |
| A | HIS267 |
| A | CYS454 |
| E | TYR604 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue MES A 502 |
| Chain | Residue |
| A | ASP105 |
| A | LYS107 |
| A | THR171 |
| A | HOH641 |
| A | HOH682 |
| A | HOH919 |
| A | HOH952 |
| A | ARG31 |
| A | ARG32 |
| A | LEU33 |
| A | ASP34 |
| A | GLY104 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | TYR35 |
| A | ARG340 |
| A | HOH694 |
| A | HOH802 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 504 |
| Chain | Residue |
| A | SER117 |
| A | HOH978 |
| A | HOH1020 |
| A | HOH1021 |
| A | HOH1105 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue MES B 701 |
| Chain | Residue |
| B | ASP34 |
| B | GLY53 |
| B | TYR71 |
| B | HIS72 |
| B | GLN73 |
| B | ASN74 |
| B | ALA109 |
| B | ALA142 |
| B | GLN146 |
| B | HOH804 |
| B | HOH862 |
| B | HOH874 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 702 |
| Chain | Residue |
| A | GLU74 |
| B | ARG51 |
| B | ARG75 |
| B | PRO105 |
| B | HOH934 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue EDO B 703 |
| Chain | Residue |
| B | MET213 |
| B | SER214 |
| B | LEU216 |
| B | THR218 |
| B | HOH1014 |
| B | HOH1025 |
| B | HOH1135 |
| D | LEU239 |
| D | TRP396 |
| D | TYR404 |
| D | HOH801 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 704 |
| Chain | Residue |
| B | MET242 |
| B | LYS243 |
| B | LYS446 |
| B | HOH852 |
| D | GLU220 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 705 |
| Chain | Residue |
| B | TRP288 |
| B | GLN356 |
| B | VAL423 |
| B | THR424 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 706 |
| Chain | Residue |
| B | SER30 |
| B | SER33 |
| B | HOH966 |
| B | HOH1175 |
| B | HOH1197 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 501 |
| Chain | Residue |
| C | HIS262 |
| C | HIS267 |
| C | CYS454 |
| F | TYR604 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue MES C 502 |
| Chain | Residue |
| C | ARG32 |
| C | LEU33 |
| C | ASP34 |
| C | GLY104 |
| C | ASP105 |
| C | LYS107 |
| C | HOH651 |
| C | HOH675 |
| C | HOH729 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 503 |
| Chain | Residue |
| C | TYR35 |
| C | ARG340 |
| C | HOH603 |
| C | HOH699 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 504 |
| Chain | Residue |
| C | ASN14 |
| C | ILE84 |
| C | HOH814 |
| C | HOH970 |
| C | HOH974 |
| C | HOH990 |
| site_id | AD6 |
| Number of Residues | 13 |
| Details | binding site for residue MES D 701 |
| Chain | Residue |
| D | HOH804 |
| D | HOH840 |
| D | HOH941 |
| D | HOH974 |
| D | ASP34 |
| D | GLY53 |
| D | TYR71 |
| D | HIS72 |
| D | GLN73 |
| D | ASN74 |
| D | ALA109 |
| D | ALA142 |
| D | GLN146 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 702 |
| Chain | Residue |
| C | GLU74 |
| C | HOH810 |
| D | ARG51 |
| D | ARG75 |
| D | PRO105 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue EDO D 703 |
| Chain | Residue |
| B | TRP396 |
| B | HOH801 |
| D | MET213 |
| D | SER214 |
| D | LEU216 |
| D | THR218 |
| D | HOH805 |
| D | HOH920 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 704 |
| Chain | Residue |
| B | GLU220 |
| D | MET242 |
| D | LYS243 |
| D | LYS446 |
| D | HOH853 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 705 |
| Chain | Residue |
| D | TRP288 |
| D | GLN356 |
| D | VAL423 |
| D | THR424 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 706 |
| Chain | Residue |
| D | SER30 |
| D | SER33 |
| D | HOH1181 |
| D | HOH1202 |
| D | HOH1212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Peptide: {"description":"Angiotensin 1-4","featureId":"PRO_0000420662","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Beta-decarboxylated aspartate; in form angiotensin-A","evidences":[{"source":"PubMed","id":"17138938","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
