Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NFR

Crystal structure of malate dehydrogenase from Plasmodium falciparum (PfMDH)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
C	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
D	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
E	0003824	molecular_function	catalytic activity
E	0004459	molecular_function	L-lactate dehydrogenase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019752	biological_process	carboxylic acid metabolic process
E	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
F	0003824	molecular_function	catalytic activity
F	0004459	molecular_function	L-lactate dehydrogenase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019752	biological_process	carboxylic acid metabolic process
F	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
G	0003824	molecular_function	catalytic activity
G	0004459	molecular_function	L-lactate dehydrogenase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019752	biological_process	carboxylic acid metabolic process
G	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
H	0003824	molecular_function	catalytic activity
H	0004459	molecular_function	L-lactate dehydrogenase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019752	biological_process	carboxylic acid metabolic process
H	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
I	0003824	molecular_function	catalytic activity
I	0004459	molecular_function	L-lactate dehydrogenase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0016491	molecular_function	oxidoreductase activity
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0019752	biological_process	carboxylic acid metabolic process
I	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
J	0003824	molecular_function	catalytic activity
J	0004459	molecular_function	L-lactate dehydrogenase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0016491	molecular_function	oxidoreductase activity
J	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J	0019752	biological_process	carboxylic acid metabolic process
J	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
K	0003824	molecular_function	catalytic activity
K	0004459	molecular_function	L-lactate dehydrogenase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0016491	molecular_function	oxidoreductase activity
K	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K	0019752	biological_process	carboxylic acid metabolic process
K	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
L	0003824	molecular_function	catalytic activity
L	0004459	molecular_function	L-lactate dehydrogenase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0016491	molecular_function	oxidoreductase activity
L	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L	0019752	biological_process	carboxylic acid metabolic process
L	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
M	0003824	molecular_function	catalytic activity
M	0004459	molecular_function	L-lactate dehydrogenase activity
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0016491	molecular_function	oxidoreductase activity
M	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
M	0019752	biological_process	carboxylic acid metabolic process
M	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
N	0003824	molecular_function	catalytic activity
N	0004459	molecular_function	L-lactate dehydrogenase activity
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0016491	molecular_function	oxidoreductase activity
N	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
N	0019752	biological_process	carboxylic acid metabolic process
N	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
O	0003824	molecular_function	catalytic activity
O	0004459	molecular_function	L-lactate dehydrogenase activity
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0016491	molecular_function	oxidoreductase activity
O	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
O	0019752	biological_process	carboxylic acid metabolic process
O	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity
P	0003824	molecular_function	catalytic activity
P	0004459	molecular_function	L-lactate dehydrogenase activity
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0016491	molecular_function	oxidoreductase activity
P	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
P	0019752	biological_process	carboxylic acid metabolic process
P	0030060	molecular_function	L-malate dehydrogenase (NAD+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue CIT A 401

Chain	Residue
A	ILE12
A	ARG81
A	ARG87
A	ASN119
A	ARG150
A	HIS174
A	GLY217
A	ILE221

site_id	AC2
Number of Residues	8
Details	binding site for residue CIT B 401

Chain	Residue
B	ARG87
B	ASN119
B	LEU146
B	ARG150
B	HIS174
B	GLY217
B	ILE221
B	ARG81

site_id	AC3
Number of Residues	9
Details	binding site for residue CIT C 401

Chain	Residue
C	ILE12
C	ARG81
C	ARG87
C	VAL117
C	ASN119
C	ARG150
C	HIS174
C	GLY217
C	ALA228

site_id	AC4
Number of Residues	9
Details	binding site for residue CIT D 401

Chain	Residue
D	ILE12
D	ARG81
D	ARG87
D	VAL117
D	ASN119
D	ARG150
D	HIS174
D	GLY217
D	ALA228

site_id	AC5
Number of Residues	10
Details	binding site for residue CIT E 401

Chain	Residue
E	ARG81
E	ARG87
E	VAL117
E	ASN119
E	LEU146
E	ARG150
E	HIS174
E	GLY217
E	ILE221
E	SER227

site_id	AC6
Number of Residues	10
Details	binding site for residue CIT F 401

Chain	Residue
F	ILE12
F	ARG81
F	ARG87
F	VAL117
F	ASN119
F	ARG150
F	HIS174
F	GLY217
F	ILE221
F	ALA228

site_id	AC7
Number of Residues	9
Details	binding site for residue CIT H 401

Chain	Residue
H	ARG81
H	ARG87
H	ASN119
H	MET142
H	ARG150
H	HIS174
H	GLY217
H	ILE221
H	ALA228

site_id	AC8
Number of Residues	10
Details	binding site for residue CIT I 401

Chain	Residue
I	ILE12
I	ARG81
I	ARG87
I	ASN119
I	ARG150
I	HIS174
I	GLY217
I	ILE221
I	SER227
I	ALA228

site_id	AC9
Number of Residues	7
Details	binding site for residue CIT J 401

Chain	Residue
J	ARG81
J	ARG87
J	ASN119
J	LEU146
J	ARG150
J	HIS174
J	GLY217

site_id	AD1
Number of Residues	10
Details	binding site for residue CIT K 401

Chain	Residue
K	ARG81
K	ARG87
K	VAL117
K	ASN119
K	ARG150
K	HIS174
K	GLY217
K	ILE221
K	SER227
K	ALA228

site_id	AD2
Number of Residues	10
Details	binding site for residue CIT L 401

Chain	Residue
L	ALA228
L	ILE12
L	ARG81
L	ARG87
L	ASN119
L	LEU146
L	ARG150
L	HIS174
L	GLY217
L	SER227

site_id	AD3
Number of Residues	8
Details	binding site for residue CIT M 401

Chain	Residue
M	ARG81
M	ARG87
M	VAL117
M	ASN119
M	ARG150
M	HIS174
M	GLY217
M	ILE221

site_id	AD4
Number of Residues	8
Details	binding site for residue CIT N 401

Chain	Residue
N	ILE12
N	ARG81
N	ARG87
N	VAL117
N	ASN119
N	ARG150
N	HIS174
N	GLY217

site_id	AD5
Number of Residues	11
Details	binding site for residue CIT O 401

Chain	Residue
O	ARG81
O	ARG87
O	VAL117
O	ASN119
O	LEU146
O	ARG150
O	HIS174
O	GLY217
O	SER227
O	ALA228
O	PRO232

site_id	AD6
Number of Residues	11
Details	binding site for residue CIT P 401

Chain	Residue
P	ARG81
P	ARG87
P	VAL117
P	ASN119
P	MET142
P	ARG150
P	HIS174
P	GLY217
P	ILE221
P	SER227
P	ALA228

site_id	AD7
Number of Residues	6
Details	binding site for Ligand ASN H 265 bound to ASN K 258

Chain	Residue
H	TYR256
H	LEU257
H	SER264
H	LEU266
K	ASN258
K	GLY259

site_id	AD8
Number of Residues	6
Details	binding site for Ligand ASN H 265 bound to ASN K 258

Chain	Residue
H	TYR256
H	LEU257
H	SER264
H	LEU266
K	ASN258
K	GLY259

site_id	AD9
Number of Residues	6
Details	binding site for Ligand ASN H 265 bound to ASN K 258

Chain	Residue
H	TYR256
H	LEU257
H	SER264
H	LEU266
K	ASN258
K	GLY259

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)