5NEB

Structure of GluK1 ligand-binding domain (S1S2) in complex with LM-12b at 2.05 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 B 301

Chain	Residue
B	ARG31
B	VAL53
B	LYS54
B	LEU55

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 B 302

Chain	Residue
B	ASP79
B	ARG81

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 B 303

Chain	Residue
B	TRP158
B	SER162
B	HOH427
B	GLY1
B	ALA2
B	LYS147

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 B 304

Chain	Residue
B	ASP58
B	LYS60
B	ASN71

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 B 305

Chain	Residue
B	ARG138
B	LEU169
B	VAL170
B	LYS171
B	GLU175

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL B 306

Chain	Residue
B	ASP100
B	PHE101

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL B 307

Chain	Residue
B	ASP212
B	SER213

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL B 308

Chain	Residue
B	THR92
B	TYR93
B	VAL94
B	LYS214

---

site_id	AC9
Number of Residues	11
Details	binding site for residue 8VE B 309

Chain	Residue
B	TYR61
B	PRO88
B	THR90
B	ARG95
B	GLY140
B	SER141
B	THR142
B	GLU190
B	SER193
B	HOH413
B	HOH423

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ACT B 310

Chain	Residue
B	ARG20
B	ASP38
B	LYS41
B	LYS249

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 A 301

Chain	Residue
A	GLY209
A	LEU210
B	HIS244

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	HIS244
A	HOH475
B	GLY209
B	LEU210

---

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG31
A	VAL53
A	LYS54
A	LEU55

---

site_id	AD5
Number of Residues	3
Details	binding site for residue CL A 304

Chain	Residue
A	PHE101
A	ARG227
A	HOH455

---

site_id	AD6
Number of Residues	1
Details	binding site for residue CL A 305

Chain	Residue
A	SER213

---

site_id	AD7
Number of Residues	7
Details	binding site for residue GOL A 306

Chain	Residue
A	THR92
A	TYR93
A	VAL94
A	LYS214
A	HOH438
A	HOH444
A	HOH469

---

site_id	AD8
Number of Residues	14
Details	binding site for residue 8VE A 307

Chain	Residue
A	TYR61
A	PRO88
A	LEU89
A	THR90
A	ARG95
A	GLY140
A	SER141
A	THR142
A	GLU190
A	SER193
A	TYR216
A	HOH421
A	HOH427
A	HOH434

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15721240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---