5ND2
Microtubule-bound MKLP2 motor domain in the presence of ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0007399 | biological_process | nervous system development |
| B | 0015630 | cellular_component | microtubule cytoskeleton |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 1902669 | biological_process | positive regulation of axon guidance |
| C | 0003777 | molecular_function | microtubule motor activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0007018 | biological_process | microtubule-based movement |
| C | 0008017 | molecular_function | microtubule binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue ADP C 601 |
| Chain | Residue |
| C | ARG69 |
| C | THR166 |
| C | TYR167 |
| C | THR172 |
| C | MG602 |
| C | ARG71 |
| C | PRO72 |
| C | VAL160 |
| C | THR161 |
| C | ASN162 |
| C | SER163 |
| C | GLY164 |
| C | LYS165 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 602 |
| Chain | Residue |
| C | THR166 |
| C | ADP601 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue GTP A 500 |
| Chain | Residue |
| A | GLY10 |
| A | GLN11 |
| A | ALA12 |
| A | GLN15 |
| A | ALA99 |
| A | ALA100 |
| A | ASN101 |
| A | SER140 |
| A | GLY142 |
| A | GLY143 |
| A | GLY144 |
| A | THR145 |
| A | THR179 |
| A | GLU183 |
| A | ASN206 |
| A | TYR224 |
| A | ASN228 |
| A | MG501 |
| B | LYS254 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | GLN11 |
| A | ASP69 |
| A | GTP500 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue GDP B 600 |
| Chain | Residue |
| B | GLY10 |
| B | GLN11 |
| B | CYS12 |
| B | GLN15 |
| B | SER140 |
| B | GLY142 |
| B | GLY143 |
| B | GLY144 |
| B | THR145 |
| B | GLY146 |
| B | ASP179 |
| B | GLU183 |
| B | ASN206 |
| B | ASN228 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue TA1 B 601 |
| Chain | Residue |
| B | GLU22 |
| B | VAL23 |
| B | ASP26 |
| B | GLU27 |
| B | ASP226 |
| B | HIS229 |
| B | LEU230 |
| B | ALA233 |
| B | SER236 |
| B | PHE272 |
| B | PRO274 |
| B | THR276 |
| B | ARG278 |
| B | ARG320 |
| B | PRO360 |
| B | LEU371 |
Functional Information from PROSITE/UniProt
| site_id | PS00227 |
| Number of Residues | 7 |
| Details | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
| Chain | Residue | Details |
| B | GLY142-GLY148 | |
| A | GLY142-GLY148 |
| site_id | PS00228 |
| Number of Residues | 4 |
| Details | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI |
| Chain | Residue | Details |
| B | MET1-ILE4 |
| site_id | PS00411 |
| Number of Residues | 12 |
| Details | KINESIN_MOTOR_1 Kinesin motor domain signature. SELsLCDLAGSE |
| Chain | Residue | Details |
| C | SER401-GLU412 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | GLU254 | |
| B | SER140 | |
| B | GLY144 | |
| B | THR145 | |
| B | GLY146 | |
| B | ASN206 | |
| B | ASN228 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | GLN11 | |
| A | GLU71 | |
| A | SER140 | |
| A | GLY144 | |
| A | THR145 | |
| A | THR179 | |
| A | ASN206 | |
| A | ASN228 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Involved in polymerization => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR451 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | LYS40 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | SER48 | |
| A | GLY232 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| A | TYR282 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | ARG339 | |
| B | THR292 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| A | SER439 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | GLU443 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369 |
| Chain | Residue | Details |
| A | GLU445 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q71U36 |
| Chain | Residue | Details |
| A | TYR451 | |
| B | LYS326 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P68363 |
| Chain | Residue | Details |
| A | LYS326 | |
| A | LYS370 |
