5NC5
Crystal structure of AcrBZ in complex with antibiotic puromycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| F | 0046677 | biological_process | response to antibiotic |
| F | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| G | 0046677 | biological_process | response to antibiotic |
| G | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| H | 0046677 | biological_process | response to antibiotic |
| H | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1101 |
| Chain | Residue |
| A | ILE27 |
| A | LEU28 |
| A | LEU30 |
| A | VAL32 |
| A | HIS338 |
| A | PHE380 |
| A | D101106 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 1102 |
| Chain | Residue |
| C | ILE18 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue D12 A 1103 |
| Chain | Residue |
| A | MET20 |
| A | TRP13 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue D10 A 1104 |
| Chain | Residue |
| A | TRP895 |
| A | D101105 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue D10 A 1105 |
| Chain | Residue |
| A | PHE885 |
| A | TRP895 |
| A | D101104 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue D10 A 1106 |
| Chain | Residue |
| A | ILE370 |
| A | LMT1101 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue D10 A 1108 |
| Chain | Residue |
| A | ALA457 |
| A | PHE458 |
| A | DD91110 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue D10 A 1109 |
| Chain | Residue |
| A | ALA385 |
| A | DD91114 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue DD9 A 1110 |
| Chain | Residue |
| A | PHE386 |
| A | D101108 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue LMT A 1111 |
| Chain | Residue |
| A | LYS29 |
| A | DD91113 |
| B | SER450 |
| B | VAL454 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue D12 A 1112 |
| Chain | Residue |
| A | ARG8 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue DD9 A 1113 |
| Chain | Residue |
| A | LMT1111 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue DD9 A 1114 |
| Chain | Residue |
| A | D101109 |
| B | DD91112 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue D10 B 1101 |
| Chain | Residue |
| B | TRP895 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue D10 B 1103 |
| Chain | Residue |
| B | TRP13 |
| B | D101110 |
| C | TRP895 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue D10 B 1105 |
| Chain | Residue |
| B | PHE885 |
| site_id | AD8 |
| Number of Residues | 1 |
| Details | binding site for residue DD9 B 1106 |
| Chain | Residue |
| C | D101104 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue DD9 B 1107 |
| Chain | Residue |
| B | LEU25 |
| C | ILE879 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue D10 B 1110 |
| Chain | Residue |
| B | D101103 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue D10 B 1111 |
| Chain | Residue |
| B | TYR467 |
| B | TYR877 |
| B | GLN928 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue DD9 B 1112 |
| Chain | Residue |
| A | DD91114 |
| B | DD91119 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue D10 B 1113 |
| Chain | Residue |
| B | PHE386 |
| B | SER476 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue D10 B 1114 |
| Chain | Residue |
| B | PHE4 |
| B | D101122 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue DD9 B 1115 |
| Chain | Residue |
| B | SER875 |
| B | ILE882 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue D10 B 1116 |
| Chain | Residue |
| B | SER880 |
| B | LEU881 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue D10 B 1117 |
| Chain | Residue |
| B | ILE27 |
| B | PHE380 |
| B | ILE390 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue DD9 B 1119 |
| Chain | Residue |
| B | ALA385 |
| B | DD91112 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue PUY B 1120 |
| Chain | Residue |
| B | SER134 |
| B | PHE136 |
| B | VAL139 |
| B | PHE178 |
| B | MET573 |
| B | PHE617 |
| B | PHE666 |
| B | LEU668 |
| B | VAL672 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue D12 B 1121 |
| Chain | Residue |
| B | ARG8 |
| C | MET447 |
| C | ALA890 |
| C | LEU891 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue D10 B 1122 |
| Chain | Residue |
| B | D101114 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue DD9 C 1101 |
| Chain | Residue |
| C | PHE458 |
| C | D121108 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue D12 C 1103 |
| Chain | Residue |
| C | TRP895 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue D10 C 1104 |
| Chain | Residue |
| B | DD91106 |
| C | PHE458 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue D12 C 1106 |
| Chain | Residue |
| A | TRP895 |
| C | TRP13 |
| site_id | AF8 |
| Number of Residues | 1 |
| Details | binding site for residue D12 C 1107 |
| Chain | Residue |
| C | PHE458 |
| site_id | AF9 |
| Number of Residues | 1 |
| Details | binding site for residue D12 C 1108 |
| Chain | Residue |
| C | DD91101 |
| site_id | AG1 |
| Number of Residues | 1 |
| Details | binding site for residue DD9 C 1109 |
| Chain | Residue |
| C | DD91110 |
| site_id | AG2 |
| Number of Residues | 1 |
| Details | binding site for residue DD9 C 1110 |
| Chain | Residue |
| C | DD91109 |
| site_id | AG3 |
| Number of Residues | 1 |
| Details | binding site for residue D10 C 1112 |
| Chain | Residue |
| C | GLN439 |
| site_id | AG4 |
| Number of Residues | 2 |
| Details | binding site for residue D10 C 1115 |
| Chain | Residue |
| C | PHE885 |
| C | D101116 |
| site_id | AG5 |
| Number of Residues | 2 |
| Details | binding site for residue D10 C 1116 |
| Chain | Residue |
| C | MET902 |
| C | D101115 |
| site_id | AG6 |
| Number of Residues | 1 |
| Details | binding site for residue D10 C 1117 |
| Chain | Residue |
| C | LEU881 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 18 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01484","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
