5NBD
PglK flippase in complex with inhibitory nanobody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006486 | biological_process | obsolete protein glycosylation |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0006869 | biological_process | lipid transport |
| A | 0015437 | molecular_function | lipopolysaccharide floppase activity |
| A | 0015920 | biological_process | lipopolysaccharide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0034040 | molecular_function | ATPase-coupled lipid transmembrane transporter activity |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006486 | biological_process | obsolete protein glycosylation |
| B | 0006487 | biological_process | protein N-linked glycosylation |
| B | 0006869 | biological_process | lipid transport |
| B | 0015437 | molecular_function | lipopolysaccharide floppase activity |
| B | 0015920 | biological_process | lipopolysaccharide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0034040 | molecular_function | ATPase-coupled lipid transmembrane transporter activity |
| B | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0140359 | molecular_function | ABC-type transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ADP A 601 |
| Chain | Residue |
| A | GLY385 |
| A | GLY387 |
| A | SER389 |
| A | THR390 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue ADP B 601 |
| Chain | Residue |
| B | GLY387 |
| B | LYS388 |
| B | SER389 |
| B | THR390 |
| B | THR125 |
| B | TYR358 |
| B | LYS361 |
| B | GLY385 |
| B | CYS386 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL |
| Chain | Residue | Details |
| A | LEU485-LEU499 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 256 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 430 |
| Details | Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 738 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 108 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 604 |
| Details | Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Region: {"description":"Important for stimulation of ATPase activity by lipid-linked oligosaccharides and subsequent translocation of lipid-linked oligosaccharides","evidences":[{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
