5NA9
The X-ray structure of bovine pancreatic ribonuclease incubated in the presence of an excess of carboplatin (1:10 ratio)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004522 | molecular_function | ribonuclease A activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue QPT A 201 |
| Chain | Residue |
| A | ASP14 |
| A | SER16 |
| A | THR17 |
| A | TYR25 |
| A | GLN28 |
| A | MET29 |
| A | SER32 |
| A | ASP53 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CS A 202 |
| Chain | Residue |
| A | GLU49 |
| A | HIS48 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CS A 203 |
| Chain | Residue |
| A | ASN62 |
| A | THR70 |
| A | TYR73 |
| A | HOH340 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CS A 204 |
| Chain | Residue |
| A | LYS31 |
| A | SER32 |
| A | ASN34 |
| A | THR78 |
| A | HOH304 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CS A 205 |
| Chain | Residue |
| A | SER23 |
| A | ASN24 |
| A | ASN113 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 206 |
| Chain | Residue |
| A | ARG10 |
| A | ASN34 |
| A | THR78 |
| A | HOH481 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 207 |
| Chain | Residue |
| A | THR3 |
| A | HOH316 |
| A | HOH463 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 208 |
| Chain | Residue |
| A | SER15 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 209 |
| Chain | Residue |
| A | LEU35 |
| A | ARG39 |
| A | HOH356 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 210 |
| Chain | Residue |
| A | THR87 |
| A | GLY88 |
| A | SER90 |
| A | LYS91 |
| A | HOH386 |
| A | HOH416 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 211 |
| Chain | Residue |
| A | ASN24 |
| A | ASN113 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 212 |
| Chain | Residue |
| A | THR36 |
| A | TYR92 |
| A | PRO93 |
| A | HOH327 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 213 |
| Chain | Residue |
| A | PHE120 |
| A | CL214 |
| A | HOH355 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 214 |
| Chain | Residue |
| A | HIS12 |
| A | ASN44 |
| A | THR45 |
| A | CL213 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF |
| Chain | Residue | Details |
| A | CYS40-PHE46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"4030761","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","featureId":"CAR_000006","evidences":[{"source":"PubMed","id":"19358553","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 164 |
| Chain | Residue | Details |
| A | HIS12 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS41 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS119 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | PHE120 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP121 | electrostatic stabiliser, hydrogen bond acceptor |
