5N7E

Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4).

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005096	molecular_function	GTPase activator activity
B	0035556	biological_process	intracellular signal transduction
B	0043547	biological_process	positive regulation of GTPase activity

Functional Information from PROSITE/UniProt

site_id	PS00741
Number of Residues	26
Details	DH_1 Dbl homology (DH) domain signature. LetLLykPVdrVtRstLvLhDLlkhT

Chain	Residue	Details
B	LEU639-THR664

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site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP

Chain	Residue	Details
A	GLY38-PRO45

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER488

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	TYR554
B	TYR644

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR641
B	THR693

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