5N6S
Thermotoga maritima family 1 Glycoside hydrolase complexed with Carba-Cyclophellitol transition state mimic
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000272 | biological_process | polysaccharide catabolic process |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008422 | molecular_function | beta-glucosidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030245 | biological_process | cellulose catabolic process |
| B | 0000272 | biological_process | polysaccharide catabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008422 | molecular_function | beta-glucosidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0030245 | biological_process | cellulose catabolic process |
| C | 0000272 | biological_process | polysaccharide catabolic process |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008422 | molecular_function | beta-glucosidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0030245 | biological_process | cellulose catabolic process |
| D | 0000272 | biological_process | polysaccharide catabolic process |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0008422 | molecular_function | beta-glucosidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0030245 | biological_process | cellulose catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | LYS286 |
| A | PRO345 |
| A | HOH672 |
| B | THR90 |
| B | LYS131 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ILE236 |
| A | HOH614 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | TYR342 |
| A | PEG508 |
| A | HOH605 |
| A | ASN253 |
| A | GLU341 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | GLY31 |
| A | MET32 |
| A | HOH727 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | ARG137 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue IMD A 506 |
| Chain | Residue |
| A | ALA54 |
| A | TYR410 |
| A | TYR421 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue 8P5 A 507 |
| Chain | Residue |
| A | GLN20 |
| A | HIS121 |
| A | TRP122 |
| A | ASN165 |
| A | GLU166 |
| A | TRP168 |
| A | VAL169 |
| A | ASN246 |
| A | TRP324 |
| A | GLU351 |
| A | TRP398 |
| A | GLU405 |
| A | TRP406 |
| A | PHE414 |
| A | HOH601 |
| A | HOH610 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PEG A 508 |
| Chain | Residue |
| A | LYS337 |
| A | GLU340 |
| A | GLU341 |
| A | EDO503 |
| A | HOH605 |
| B | ARG148 |
| B | GLU152 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 501 |
| Chain | Residue |
| B | ARG240 |
| B | TRP333 |
| B | LYS337 |
| B | HOH633 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | VAL53 |
| B | ALA54 |
| B | TYR410 |
| B | TYR421 |
| B | GLN424 |
| B | HOH660 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | PRO87 |
| B | GLU88 |
| B | HOH603 |
| B | HOH607 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | LYS376 |
| B | TRP434 |
| B | LEU444 |
| B | GLU445 |
| B | ACT512 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | TYR177 |
| B | PHE245 |
| B | PRO307 |
| B | ALA308 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | GLU69 |
| B | GLY72 |
| B | VAL73 |
| B | LYS111 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | MET322 |
| B | HOH638 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | ILE255 |
| B | TYR256 |
| B | GLU285 |
| B | LYS286 |
| B | ILE287 |
| B | HOH601 |
| B | HOH661 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 509 |
| Chain | Residue |
| B | GLY9 |
| B | HOH620 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 510 |
| Chain | Residue |
| B | GLY31 |
| B | MET32 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residue 8P5 B 511 |
| Chain | Residue |
| B | GLN20 |
| B | HIS121 |
| B | TRP122 |
| B | ASN165 |
| B | GLU166 |
| B | TRP168 |
| B | VAL169 |
| B | ASN246 |
| B | GLU351 |
| B | TRP398 |
| B | GLU405 |
| B | TRP406 |
| B | PHE414 |
| B | HOH610 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 512 |
| Chain | Residue |
| B | GLN369 |
| B | ILE372 |
| B | EDO504 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 501 |
| Chain | Residue |
| A | LEU130 |
| C | ALA135 |
| C | ARG192 |
| C | ASN196 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| C | ARG269 |
| C | GLU270 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 503 |
| Chain | Residue |
| C | ALA27 |
| C | ASP28 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 504 |
| Chain | Residue |
| C | ASN136 |
| C | ARG137 |
| site_id | AE7 |
| Number of Residues | 11 |
| Details | binding site for residue 8P5 C 505 |
| Chain | Residue |
| C | GLN20 |
| C | HIS121 |
| C | ASN165 |
| C | GLU166 |
| C | TYR295 |
| C | GLU351 |
| C | TRP398 |
| C | GLU405 |
| C | TRP406 |
| C | PHE414 |
| C | HOH612 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT C 506 |
| Chain | Residue |
| C | SER296 |
| C | HIS298 |
| C | TRP324 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 501 |
| Chain | Residue |
| D | SER18 |
| D | TYR19 |
| D | GLU22 |
| D | GLY23 |
| D | GLY51 |
| D | ARG84 |
| D | HOH606 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 502 |
| Chain | Residue |
| D | HIS180 |
| D | GLU405 |
| D | TRP406 |
| D | ALA407 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| C | GLU231 |
| D | ALA54 |
| D | TYR410 |
| D | TYR421 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 504 |
| Chain | Residue |
| B | LEU130 |
| D | ALA135 |
| D | ARG192 |
| D | ASN196 |
| D | HOH601 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 505 |
| Chain | Residue |
| D | ARG137 |
| D | HOH616 |
| site_id | AF5 |
| Number of Residues | 10 |
| Details | binding site for residue 8P5 D 506 |
| Chain | Residue |
| D | GLN20 |
| D | HIS121 |
| D | ASN165 |
| D | GLU166 |
| D | TYR295 |
| D | GLU351 |
| D | TRP398 |
| D | GLU405 |
| D | TRP406 |
| D | PHE414 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residues PEG B 513 and PGE B 514 |
| Chain | Residue |
| B | GLN369 |
| B | ASP373 |
| B | LYS376 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residues PEG B 513 and PGE B 514 |
| Chain | Residue |
| B | GLN369 |
| B | ASP373 |
| B | LYS376 |
Functional Information from PROSITE/UniProt
| site_id | PS00572 |
| Number of Residues | 9 |
| Details | GLYCOSYL_HYDROL_F1_1 Glycosyl hydrolases family 1 active site. VYITENGAA |
| Chain | Residue | Details |
| A | VAL347-ALA355 |
| site_id | PS00653 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FlWGvAtASYQiEgS |
| Chain | Residue | Details |
| A | PHE10-SER24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
