Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

5N4W

Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0010498biological_processproteasomal protein catabolic process
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0030163biological_processprotein catabolic process
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0031462cellular_componentCul2-RING ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0031981cellular_componentnuclear lumen
A0097193biological_processintrinsic apoptotic signaling pathway
A0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A0160072molecular_functionubiquitin ligase complex scaffold activity
B0006368biological_processtranscription elongation by RNA polymerase II
B0030891cellular_componentVCB complex
B0070449cellular_componentelongin complex
C0006511biological_processubiquitin-dependent protein catabolic process
R0000045biological_processautophagosome assembly
R0000082biological_processG1/S transition of mitotic cell cycle
R0000165biological_processMAPK cascade
R0000209biological_processprotein polyubiquitination
R0000423biological_processmitophagy
R0001837biological_processepithelial to mesenchymal transition
R0004842molecular_functionubiquitin-protein transferase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0006281biological_processDNA repair
R0006283biological_processtranscription-coupled nucleotide-excision repair
R0006366biological_processtranscription by RNA polymerase II
R0006368biological_processtranscription elongation by RNA polymerase II
R0006511biological_processubiquitin-dependent protein catabolic process
R0006513biological_processprotein monoubiquitination
R0006915biological_processapoptotic process
R0006974biological_processDNA damage response
R0006979biological_processresponse to oxidative stress
R0007040biological_processlysosome organization
R0007283biological_processspermatogenesis
R0007346biological_processregulation of mitotic cell cycle
R0008270molecular_functionzinc ion binding
R0008286biological_processinsulin receptor signaling pathway
R0010507biological_processnegative regulation of autophagy
R0010508biological_processpositive regulation of autophagy
R0016567biological_processprotein ubiquitination
R0016740molecular_functiontransferase activity
R0019005cellular_componentSCF ubiquitin ligase complex
R0019221biological_processcytokine-mediated signaling pathway
R0019788molecular_functionNEDD8 transferase activity
R0030163biological_processprotein catabolic process
R0030330biological_processDNA damage response, signal transduction by p53 class mediator
R0030891cellular_componentVCB complex
R0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R0031461cellular_componentcullin-RING ubiquitin ligase complex
R0031462cellular_componentCul2-RING ubiquitin ligase complex
R0031463cellular_componentCul3-RING ubiquitin ligase complex
R0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
R0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
R0031466cellular_componentCul5-RING ubiquitin ligase complex
R0031467cellular_componentCul7-RING ubiquitin ligase complex
R0031625molecular_functionubiquitin protein ligase binding
R0031669biological_processcellular response to nutrient levels
R0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
R0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
R0032480biological_processnegative regulation of type I interferon production
R0032481biological_processpositive regulation of type I interferon production
R0032869biological_processcellular response to insulin stimulus
R0034198biological_processcellular response to amino acid starvation
R0034450molecular_functionubiquitin-ubiquitin ligase activity
R0034599biological_processcellular response to oxidative stress
R0034644biological_processcellular response to UV
R0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
R0038066biological_processp38MAPK cascade
R0038202biological_processTORC1 signaling
R0042110biological_processT cell activation
R0042770biological_processsignal transduction in response to DNA damage
R0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
R0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0043687biological_processpost-translational protein modification
R0044877molecular_functionprotein-containing complex binding
R0045116biological_processprotein neddylation
R0045727biological_processpositive regulation of translation
R0045732biological_processpositive regulation of protein catabolic process
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0046627biological_processnegative regulation of insulin receptor signaling pathway
R0046872molecular_functionmetal ion binding
R0060090molecular_functionmolecular adaptor activity
R0060337biological_processtype I interferon-mediated signaling pathway
R0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
R0061630molecular_functionubiquitin protein ligase activity
R0061663molecular_functionNEDD8 ligase activity
R0062197biological_processcellular response to chemical stress
R0070294biological_processrenal sodium ion absorption
R0070936biological_processprotein K48-linked ubiquitination
R0071230biological_processcellular response to amino acid stimulus
R0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
R0090090biological_processnegative regulation of canonical Wnt signaling pathway
R0090734cellular_componentsite of DNA damage
R0097510biological_processbase-excision repair, AP site formation via deaminated base removal
R0097602molecular_functioncullin family protein binding
R0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R0160240biological_processRNA polymerase II transcription initiation surveillance
R1900076biological_processregulation of cellular response to insulin stimulus
R1901525biological_processnegative regulation of mitophagy
R1901797biological_processnegative regulation of signal transduction by p53 class mediator
R1902499biological_processpositive regulation of protein autoubiquitination
R1902883biological_processnegative regulation of response to oxidative stress
R1904037biological_processpositive regulation of epithelial cell apoptotic process
R1904262biological_processnegative regulation of TORC1 signaling
R1904263biological_processpositive regulation of TORC1 signaling
R2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN R 201
ChainResidue
RCYS42
RCYS45
RHIS80
RCYS83

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN R 202
ChainResidue
RCYS53
RCYS56
RCYS68
RHIS82

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN R 203
ChainResidue
RHIS77
RCYS94
RASP97
RCYS75

Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIevLIDKqYIeRsqasadeYsYvA
ChainResidueDetails
AILE718-ALA745

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
BMET1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869
ChainResidueDetails
BTHR84
RCYS45
RCYS75
RHIS77
RHIS80
RCYS94
RASP97

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:38605244, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DPL, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O, ECO:0007744|PDB:7Z8B, ECO:0007744|PDB:8Q7H, ECO:0007744|PDB:8RHZ
ChainResidueDetails
RCYS53
RCYS56
RCYS68
RHIS82

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:38605244, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O, ECO:0007744|PDB:8Q7H, ECO:0007744|PDB:8RHZ
ChainResidueDetails
RCYS83

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:20068231
ChainResidueDetails
RMET1

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N-acetylalanine; in E3 ubiquitin-protein ligase RBX1, N-terminally processed => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
RALA2

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
RTHR9

237423

PDB entries from 2025-06-11

PDB statisticsPDBj update infoContact PDBjnumon