Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5N47

Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0002376	biological_process	immune system process
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006811	biological_process	monoatomic ion transport
A	0006826	biological_process	iron ion transport
A	0006915	biological_process	apoptotic process
A	0006953	biological_process	acute-phase response
A	0006979	biological_process	response to oxidative stress
A	0007614	biological_process	short-term memory
A	0007616	biological_process	long-term memory
A	0009410	biological_process	response to xenobiotic stimulus
A	0009615	biological_process	response to virus
A	0009617	biological_process	response to bacterium
A	0009635	biological_process	response to herbicide
A	0009636	biological_process	response to toxic substance
A	0009637	biological_process	response to blue light
A	0009750	biological_process	response to fructose
A	0010040	biological_process	response to iron(II) ion
A	0010046	biological_process	response to mycotoxin
A	0010595	biological_process	positive regulation of endothelial cell migration
A	0010628	biological_process	positive regulation of gene expression
A	0015891	biological_process	siderophore transport
A	0031346	biological_process	positive regulation of cell projection organization
A	0031410	cellular_component	cytoplasmic vesicle
A	0031667	biological_process	response to nutrient levels
A	0031669	biological_process	cellular response to nutrient levels
A	0032496	biological_process	response to lipopolysaccharide
A	0035580	cellular_component	specific granule lumen
A	0036094	molecular_function	small molecule binding
A	0036295	biological_process	cellular response to increased oxygen levels
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0043065	biological_process	positive regulation of apoptotic process
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0045087	biological_process	innate immune response
A	0060205	cellular_component	cytoplasmic vesicle lumen
A	0070062	cellular_component	extracellular exosome
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071347	biological_process	cellular response to interleukin-1
A	0071354	biological_process	cellular response to interleukin-6
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0071456	biological_process	cellular response to hypoxia
A	0071481	biological_process	cellular response to X-ray
A	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
A	0110090	biological_process	positive regulation of hippocampal neuron apoptotic process
A	0110091	biological_process	negative regulation of hippocampal neuron apoptotic process
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	0140315	molecular_function	iron ion sequestering activity
A	1903428	biological_process	positive regulation of reactive oxygen species biosynthetic process
A	1903981	molecular_function	enterobactin binding
A	1904373	biological_process	response to kainic acid
A	1904440	biological_process	positive regulation of iron ion import across plasma membrane
A	1904646	biological_process	cellular response to amyloid-beta
A	1905956	biological_process	positive regulation of endothelial tube morphogenesis
A	1990090	biological_process	cellular response to nerve growth factor stimulus
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	0002020	molecular_function	protease binding
C	0002376	biological_process	immune system process
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006811	biological_process	monoatomic ion transport
C	0006826	biological_process	iron ion transport
C	0006915	biological_process	apoptotic process
C	0006953	biological_process	acute-phase response
C	0006979	biological_process	response to oxidative stress
C	0007614	biological_process	short-term memory
C	0007616	biological_process	long-term memory
C	0009410	biological_process	response to xenobiotic stimulus
C	0009615	biological_process	response to virus
C	0009617	biological_process	response to bacterium
C	0009635	biological_process	response to herbicide
C	0009636	biological_process	response to toxic substance
C	0009637	biological_process	response to blue light
C	0009750	biological_process	response to fructose
C	0010040	biological_process	response to iron(II) ion
C	0010046	biological_process	response to mycotoxin
C	0010595	biological_process	positive regulation of endothelial cell migration
C	0010628	biological_process	positive regulation of gene expression
C	0015891	biological_process	siderophore transport
C	0031346	biological_process	positive regulation of cell projection organization
C	0031410	cellular_component	cytoplasmic vesicle
C	0031667	biological_process	response to nutrient levels
C	0031669	biological_process	cellular response to nutrient levels
C	0032496	biological_process	response to lipopolysaccharide
C	0035580	cellular_component	specific granule lumen
C	0036094	molecular_function	small molecule binding
C	0036295	biological_process	cellular response to increased oxygen levels
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0043065	biological_process	positive regulation of apoptotic process
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0045087	biological_process	innate immune response
C	0060205	cellular_component	cytoplasmic vesicle lumen
C	0070062	cellular_component	extracellular exosome
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071347	biological_process	cellular response to interleukin-1
C	0071354	biological_process	cellular response to interleukin-6
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0071456	biological_process	cellular response to hypoxia
C	0071481	biological_process	cellular response to X-ray
C	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
C	0110090	biological_process	positive regulation of hippocampal neuron apoptotic process
C	0110091	biological_process	negative regulation of hippocampal neuron apoptotic process
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0140315	molecular_function	iron ion sequestering activity
C	1903428	biological_process	positive regulation of reactive oxygen species biosynthetic process
C	1903981	molecular_function	enterobactin binding
C	1904373	biological_process	response to kainic acid
C	1904440	biological_process	positive regulation of iron ion import across plasma membrane
C	1904646	biological_process	cellular response to amyloid-beta
C	1905956	biological_process	positive regulation of endothelial tube morphogenesis
C	1990090	biological_process	cellular response to nerve growth factor stimulus
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
E	0002020	molecular_function	protease binding
E	0002376	biological_process	immune system process
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006811	biological_process	monoatomic ion transport
E	0006826	biological_process	iron ion transport
E	0006915	biological_process	apoptotic process
E	0006953	biological_process	acute-phase response
E	0006979	biological_process	response to oxidative stress
E	0007614	biological_process	short-term memory
E	0007616	biological_process	long-term memory
E	0009410	biological_process	response to xenobiotic stimulus
E	0009615	biological_process	response to virus
E	0009617	biological_process	response to bacterium
E	0009635	biological_process	response to herbicide
E	0009636	biological_process	response to toxic substance
E	0009637	biological_process	response to blue light
E	0009750	biological_process	response to fructose
E	0010040	biological_process	response to iron(II) ion
E	0010046	biological_process	response to mycotoxin
E	0010595	biological_process	positive regulation of endothelial cell migration
E	0010628	biological_process	positive regulation of gene expression
E	0015891	biological_process	siderophore transport
E	0031346	biological_process	positive regulation of cell projection organization
E	0031410	cellular_component	cytoplasmic vesicle
E	0031667	biological_process	response to nutrient levels
E	0031669	biological_process	cellular response to nutrient levels
E	0032496	biological_process	response to lipopolysaccharide
E	0035580	cellular_component	specific granule lumen
E	0036094	molecular_function	small molecule binding
E	0036295	biological_process	cellular response to increased oxygen levels
E	0042742	biological_process	defense response to bacterium
E	0042802	molecular_function	identical protein binding
E	0043065	biological_process	positive regulation of apoptotic process
E	0043525	biological_process	positive regulation of neuron apoptotic process
E	0045087	biological_process	innate immune response
E	0060205	cellular_component	cytoplasmic vesicle lumen
E	0070062	cellular_component	extracellular exosome
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0071347	biological_process	cellular response to interleukin-1
E	0071354	biological_process	cellular response to interleukin-6
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0071456	biological_process	cellular response to hypoxia
E	0071481	biological_process	cellular response to X-ray
E	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
E	0110090	biological_process	positive regulation of hippocampal neuron apoptotic process
E	0110091	biological_process	negative regulation of hippocampal neuron apoptotic process
E	0120162	biological_process	positive regulation of cold-induced thermogenesis
E	0140315	molecular_function	iron ion sequestering activity
E	1903428	biological_process	positive regulation of reactive oxygen species biosynthetic process
E	1903981	molecular_function	enterobactin binding
E	1904373	biological_process	response to kainic acid
E	1904440	biological_process	positive regulation of iron ion import across plasma membrane
E	1904646	biological_process	cellular response to amyloid-beta
E	1905956	biological_process	positive regulation of endothelial tube morphogenesis
E	1990090	biological_process	cellular response to nerve growth factor stimulus
E	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	14
Details	LIPOCALIN Lipocalin signature. NFQdnQFHGKWYVV

Chain	Residue	Details
A	ASN21-VAL34

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16037490, ECO:0000269\|PubMed:16335952

Chain	Residue	Details
B	ASN1244
D	ASN1244
F	ASN1244

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0007744\|PDB:3CMP

Chain	Residue	Details
A	PHE106
A	PHE134
C	PHE106
C	PHE134
E	PHE106
E	PHE134

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:15642259, ECO:0007744\|PDB:1X89, ECO:0007744\|PDB:1X8U

Chain	Residue	Details
A	THR125
A	TYR138
C	THR125
C	TYR138
E	THR125
E	TYR138

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269\|PubMed:7683678

Chain	Residue	Details
A	GLN1
C	GLN1
E	GLN1

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10684642, ECO:0000269\|PubMed:15084671, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:16740002, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7683678, ECO:0007744\|PDB:1DFV, ECO:0007744\|PDB:1QQS

Chain	Residue	Details
A	ASN65
C	ASN65
E	ASN65

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)