5MZF
Crystal structure of dog MTH1 protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001669 | cellular_component | acrosomal vesicle |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| A | 0008828 | molecular_function | dATP diphosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| A | 0042262 | biological_process | DNA protection |
| A | 0106377 | molecular_function | 2-hydroxy-ATP hydrolase activity |
| A | 0106378 | molecular_function | 2-hydroxy-dATP hydrolase activity |
| A | 0106431 | molecular_function | N6-methyl-(d)ATP hydrolase activity |
| A | 0106433 | molecular_function | O6-methyl-dGTP hydrolase activity |
| B | 0001669 | cellular_component | acrosomal vesicle |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| B | 0008828 | molecular_function | dATP diphosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| B | 0042262 | biological_process | DNA protection |
| B | 0106377 | molecular_function | 2-hydroxy-ATP hydrolase activity |
| B | 0106378 | molecular_function | 2-hydroxy-dATP hydrolase activity |
| B | 0106431 | molecular_function | N6-methyl-(d)ATP hydrolase activity |
| B | 0106433 | molecular_function | O6-methyl-dGTP hydrolase activity |
| C | 0001669 | cellular_component | acrosomal vesicle |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006152 | biological_process | purine nucleoside catabolic process |
| C | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| C | 0008828 | molecular_function | dATP diphosphatase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0031965 | cellular_component | nuclear membrane |
| C | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| C | 0042262 | biological_process | DNA protection |
| C | 0106377 | molecular_function | 2-hydroxy-ATP hydrolase activity |
| C | 0106378 | molecular_function | 2-hydroxy-dATP hydrolase activity |
| C | 0106431 | molecular_function | N6-methyl-(d)ATP hydrolase activity |
| C | 0106433 | molecular_function | O6-methyl-dGTP hydrolase activity |
| D | 0001669 | cellular_component | acrosomal vesicle |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006152 | biological_process | purine nucleoside catabolic process |
| D | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| D | 0008828 | molecular_function | dATP diphosphatase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0031965 | cellular_component | nuclear membrane |
| D | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| D | 0042262 | biological_process | DNA protection |
| D | 0106377 | molecular_function | 2-hydroxy-ATP hydrolase activity |
| D | 0106378 | molecular_function | 2-hydroxy-dATP hydrolase activity |
| D | 0106431 | molecular_function | N6-methyl-(d)ATP hydrolase activity |
| D | 0106433 | molecular_function | O6-methyl-dGTP hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | HIS65 |
| A | LYS66 |
| A | LYS132 |
| A | HOH310 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | TYR7 |
| A | THR8 |
| A | LEU9 |
| A | PHE27 |
| A | ACT203 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 203 |
| Chain | Residue |
| A | ASN33 |
| A | PHE72 |
| A | TRP117 |
| A | ASP119 |
| A | ASP120 |
| A | SO4202 |
| A | HOH308 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue ACT A 204 |
| Chain | Residue |
| A | GLY21 |
| A | MET22 |
| A | LYS23 |
| A | ASN33 |
| A | GLY34 |
| A | PHE35 |
| A | GLU56 |
| A | MET101 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 205 |
| Chain | Residue |
| A | PHE113 |
| A | SER121 |
| A | PHE124 |
| A | GOL206 |
| D | PHE113 |
| D | SER121 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 206 |
| Chain | Residue |
| A | PRO125 |
| A | LEU128 |
| A | GLN129 |
| A | GOL205 |
| D | LEU128 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | ASP147 |
| B | TYR148 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 202 |
| Chain | Residue |
| B | ASN33 |
| B | PHE72 |
| B | TRP117 |
| B | ASP119 |
| B | HOH312 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 203 |
| Chain | Residue |
| B | TYR136 |
| B | ARG138 |
| B | ASP147 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 204 |
| Chain | Residue |
| B | GLY76 |
| B | GLY141 |
| B | HOH371 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| C | LYS24 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 203 |
| Chain | Residue |
| C | HIS65 |
| C | LYS66 |
| C | LYS132 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 204 |
| Chain | Residue |
| A | ARG54 |
| C | ARG151 |
| C | HOH354 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 205 |
| Chain | Residue |
| C | ASN33 |
| C | TRP117 |
| C | ASP119 |
| C | HOH305 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 206 |
| Chain | Residue |
| B | PHE113 |
| B | SER121 |
| B | PRO125 |
| C | PHE113 |
| C | SER121 |
| C | PRO125 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 201 |
| Chain | Residue |
| D | HIS65 |
| D | LYS66 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 202 |
| Chain | Residue |
| D | ASN33 |
| D | PHE72 |
| D | TRP117 |
| D | ASP119 |
| D | HOH305 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GkvqegEtiedGAkRELrEEsG |
| Chain | Residue | Details |
| A | GLY37-GLY58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 516 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 84 |
| Details | Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P36639","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q7ZWC3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
