5MXX

Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue W4A A 701

Chain	Residue
A	LEU86
A	TYR227
A	LEU231
A	HOH883
A	PHE165
A	GLU166
A	VAL167
A	LEU168
A	GLY169
A	HIS170
A	LEU220
A	VAL223

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 702

Chain	Residue
A	LYS615
A	HOH832
A	HOH836
A	HOH853
A	HOH947

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 703

Chain	Residue
A	ASP138
A	ASN140
A	ASP201
A	TYR202
A	LYS206
A	HOH877
A	HOH955

---

site_id	AC4
Number of Residues	3
Details	binding site for residue EDO A 704

Chain	Residue
A	THR205
A	HOH864
A	HOH941

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 705

Chain	Residue
A	LEU122
A	ASP150
A	PHE151
A	LYS152
A	ILE161

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO A 706

Chain	Residue
A	ASN500
A	HOH838

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 707

Chain	Residue
A	LEU186
A	TRP618
A	GLU622
A	EDO708
A	HOH833
A	HOH944

---

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 708

Chain	Residue
A	GLN182
A	EDO707

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 709

Chain	Residue
A	ILE176
A	GLU543
A	GLY547
A	TYR549
A	LYS602

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 710

Chain	Residue
A	GLU610
A	GLU614
A	GLU614
A	HOH808

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO A 711

Chain	Residue
A	GLU124
A	VAL145
A	PHE165
A	ALA496
A	ASP497
A	LEU498

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 712

Chain	Residue
A	SER130
A	SER134
A	ALA624
A	HOH815
A	HOH963

---

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO A 713

Chain	Residue
A	TYR549
A	LYS615
A	TYR616
A	HOH888

---

site_id	AD5
Number of Residues	7
Details	binding site for residue CA A 714

Chain	Residue
A	GLU610
A	GLU614
A	GLU614
A	GLU617
A	CA715
A	HOH977
A	HOH989

---

site_id	AD6
Number of Residues	7
Details	binding site for residue CA A 715

Chain	Residue
A	GLU610
A	GLU617
A	CA714
A	HOH858
A	HOH938
A	HOH980
A	HOH992

---

site_id	AD7
Number of Residues	6
Details	binding site for residue CA A 716

Chain	Residue
A	GLU610
A	GLU614
A	GLU614
A	GLU617
A	HOH977
A	HOH989

---

site_id	AD8
Number of Residues	6
Details	binding site for residue CA A 717

Chain	Residue
A	GLU610
A	GLU617
A	HOH858
A	HOH938
A	HOH980
A	HOH992

---

site_id	AD9
Number of Residues	9
Details	binding site for residue TRS A 718

Chain	Residue
A	HOH841
A	HOH951
A	GLU552
A	GLU552
A	HIS554
A	ASP564
A	HOH801
A	HOH810
A	HOH839

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlSwdiqgkkf..........VAMK

Chain	Residue	Details
A	LEU86-LYS109

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ItHtDIKpeNILL

Chain	Residue	Details
A	ILE209-LEU221

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16209947","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"12565829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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