5MXR

Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-330 Inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS114
A	HIS116
A	HIS179
A	HOH413

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site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 302

Chain	Residue
A	ASP118
A	CYS198
A	HIS240
A	JTY305
A	HOH413

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 303

Chain	Residue
A	HIS153
A	HIS251
A	ACT304
A	JTY306

---

site_id	AC4
Number of Residues	9
Details	binding site for residue ACT A 304

Chain	Residue
A	ALA132
A	THR133
A	THR152
A	HIS153
A	ASP247
A	HIS251
A	ZN303
A	JTY306
A	HOH410

---

site_id	AC5
Number of Residues	14
Details	binding site for residue JTY A 305

Chain	Residue
A	PHE62
A	TYR67
A	TRP87
A	ASP118
A	HIS179
A	CYS198
A	ARG205
A	GLY209
A	ASN210
A	HIS240
A	ZN302
A	HOH401
A	HOH413
A	HOH480

---

site_id	AC6
Number of Residues	10
Details	binding site for residue JTY A 306

Chain	Residue
A	GLY130
A	ALA132
A	HIS153
A	THR206
A	HIS251
A	ASN254
A	VAL255
A	ZN303
A	ACT304
A	HOH412

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