Functional Information from GO Data
| Chain | GOid | namespace | contents |
| U | 0005125 | molecular_function | cytokine activity |
| U | 0005615 | cellular_component | extracellular space |
| U | 0006954 | biological_process | inflammatory response |
| U | 0006955 | biological_process | immune response |
| V | 0005125 | molecular_function | cytokine activity |
| V | 0005615 | cellular_component | extracellular space |
| V | 0006954 | biological_process | inflammatory response |
| V | 0006955 | biological_process | immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL H 301 |
| Chain | Residue |
| H | GLY167 |
| H | HIS169 |
| H | THR188 |
| H | HOH426 |
| L | ASN137 |
| L | ASN138 |
| L | ASP167 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL L 301 |
| Chain | Residue |
| L | GLU165 |
| L | GLN166 |
| L | HOH405 |
| L | HOH435 |
| L | HOH523 |
| L | LYS103 |
| L | ILE106 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL L 302 |
| Chain | Residue |
| B | LYS169 |
| B | SER171 |
| B | GOL303 |
| L | PRO15 |
| L | PRO80 |
| L | HOH418 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL L 303 |
| Chain | Residue |
| B | SER76 |
| B | HOH418 |
| L | ARG108 |
| L | ASP170 |
| L | HOH445 |
| L | HOH452 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | SER7 |
| A | ALA9 |
| A | GLN110 |
| A | GLY111 |
| A | THR112 |
| A | MET113 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 301 |
| Chain | Residue |
| A | PHE171 |
| A | PRO172 |
| A | SER182 |
| A | LEU183 |
| A | SER184 |
| B | GLN160 |
| B | SER162 |
| B | SER176 |
| B | SER177 |
| B | THR178 |
| B | HOH413 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | LYS103 |
| B | ILE106 |
| B | GLU165 |
| B | GLN166 |
| B | HOH409 |
| B | HOH450 |
| B | HOH510 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | PRO15 |
| B | GLY16 |
| B | LEU78 |
| B | HOH429 |
| L | PRO15 |
| L | LYS169 |
| L | ASP170 |
| L | SER171 |
| L | GOL302 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide LYS V 55 and SER A 133 |
| Chain | Residue |
| A | TYR52 |
| A | PRO53 |
| A | GLY54 |
| A | SER56 |
| A | ASP57 |
| A | SER132 |
| A | SER132 |
| A | LYS134 |
| A | LYS134 |
| A | SER135 |
| A | SER135 |
| A | THR136 |
| A | CYS221 |
| V | ASP54 |
| V | ILE56 |
| V | PRO57 |
| V | LYS103 |
| V | GLU105 |
| V | SER123 |
| V | THR124 |
| V | SER125 |
| V | PRO131 |
| V | VAL132 |
| V | LEU134 |
| V | ASP142 |
Functional Information from PROSITE/UniProt
| site_id | PS00253 |
| Number of Residues | 21 |
| Details | INTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV |
| Chain | Residue | Details |
| U | PHE112-VAL132 | |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| H | TYR199-HIS205 | |
| L | TYR192-HIS198 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Motif: {"description":"Involved in interaction with TMED10 C-terminus","evidences":[{"source":"PubMed","id":"32272059","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Involved in receptor binding"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"29030430","evidenceCode":"ECO:0000269"}]} |
