Functional Information from GO Data
Chain | GOid | namespace | contents |
U | 0005125 | molecular_function | cytokine activity |
U | 0005615 | cellular_component | extracellular space |
U | 0006954 | biological_process | inflammatory response |
U | 0006955 | biological_process | immune response |
V | 0005125 | molecular_function | cytokine activity |
V | 0005615 | cellular_component | extracellular space |
V | 0006954 | biological_process | inflammatory response |
V | 0006955 | biological_process | immune response |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue GOL H 301 |
Chain | Residue |
H | GLY167 |
H | HIS169 |
H | THR188 |
H | HOH426 |
L | ASN137 |
L | ASN138 |
L | ASP167 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue GOL L 301 |
Chain | Residue |
L | GLU165 |
L | GLN166 |
L | HOH405 |
L | HOH435 |
L | HOH523 |
L | LYS103 |
L | ILE106 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue GOL L 302 |
Chain | Residue |
B | LYS169 |
B | SER171 |
B | GOL303 |
L | PRO15 |
L | PRO80 |
L | HOH418 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue GOL L 303 |
Chain | Residue |
B | SER76 |
B | HOH418 |
L | ARG108 |
L | ASP170 |
L | HOH445 |
L | HOH452 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 301 |
Chain | Residue |
A | SER7 |
A | ALA9 |
A | GLN110 |
A | GLY111 |
A | THR112 |
A | MET113 |
site_id | AC6 |
Number of Residues | 11 |
Details | binding site for residue GOL B 301 |
Chain | Residue |
A | PHE171 |
A | PRO172 |
A | SER182 |
A | LEU183 |
A | SER184 |
B | GLN160 |
B | SER162 |
B | SER176 |
B | SER177 |
B | THR178 |
B | HOH413 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue GOL B 302 |
Chain | Residue |
B | LYS103 |
B | ILE106 |
B | GLU165 |
B | GLN166 |
B | HOH409 |
B | HOH450 |
B | HOH510 |
site_id | AC8 |
Number of Residues | 9 |
Details | binding site for residue GOL B 303 |
Chain | Residue |
B | PRO15 |
B | GLY16 |
B | LEU78 |
B | HOH429 |
L | PRO15 |
L | LYS169 |
L | ASP170 |
L | SER171 |
L | GOL302 |
site_id | AC9 |
Number of Residues | 25 |
Details | binding site for Di-peptide LYS V 55 and SER A 133 |
Chain | Residue |
A | TYR52 |
A | PRO53 |
A | GLY54 |
A | SER56 |
A | ASP57 |
A | SER132 |
A | SER132 |
A | LYS134 |
A | LYS134 |
A | SER135 |
A | SER135 |
A | THR136 |
A | CYS221 |
V | ASP54 |
V | ILE56 |
V | PRO57 |
V | LYS103 |
V | GLU105 |
V | SER123 |
V | THR124 |
V | SER125 |
V | PRO131 |
V | VAL132 |
V | LEU134 |
V | ASP142 |
Functional Information from PROSITE/UniProt
site_id | PS00253 |
Number of Residues | 21 |
Details | INTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV |
Chain | Residue | Details |
U | PHE112-VAL132 | |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
Chain | Residue | Details |
H | TYR199-HIS205 | |
L | TYR192-HIS198 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Involved in receptor binding |
Chain | Residue | Details |
U | ARG4 | |
V | ARG4 | |
Chain | Residue | Details |
U | LYS55 | |
V | LYS88 | |
U | LYS63 | |
U | LYS65 | |
U | LYS74 | |
U | LYS88 | |
V | LYS55 | |
V | LYS63 | |
V | LYS65 | |
V | LYS74 | |