5MRW

Structure of the KdpFABC complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006813	biological_process	potassium ion transport
A	0008556	molecular_function	P-type potassium transmembrane transporter activity
A	0030955	molecular_function	potassium ion binding
A	0031004	cellular_component	potassium ion-transporting ATPase complex
A	0071805	biological_process	potassium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	1903103	cellular_component	potassium:proton antiporter complex
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005215	molecular_function	transporter activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006813	biological_process	potassium ion transport
B	0008556	molecular_function	P-type potassium transmembrane transporter activity
B	0015662	molecular_function	P-type ion transporter activity
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0031004	cellular_component	potassium ion-transporting ATPase complex
B	0046872	molecular_function	metal ion binding
B	0071805	biological_process	potassium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	1903103	cellular_component	potassium:proton antiporter complex
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006813	biological_process	potassium ion transport
C	0008556	molecular_function	P-type potassium transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0031004	cellular_component	potassium ion-transporting ATPase complex
C	0071805	biological_process	potassium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	1903103	cellular_component	potassium:proton antiporter complex
D	0005886	cellular_component	plasma membrane
D	0006813	biological_process	potassium ion transport
D	0008556	molecular_function	P-type potassium transmembrane transporter activity
D	0031004	cellular_component	potassium ion-transporting ATPase complex
D	0043462	biological_process	regulation of ATP-dependent activity
D	0071805	biological_process	potassium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	1903103	cellular_component	potassium:proton antiporter complex
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006813	biological_process	potassium ion transport
E	0008556	molecular_function	P-type potassium transmembrane transporter activity
E	0030955	molecular_function	potassium ion binding
E	0031004	cellular_component	potassium ion-transporting ATPase complex
E	0071805	biological_process	potassium ion transmembrane transport
E	0098655	biological_process	monoatomic cation transmembrane transport
E	1903103	cellular_component	potassium:proton antiporter complex
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0005215	molecular_function	transporter activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006813	biological_process	potassium ion transport
F	0008556	molecular_function	P-type potassium transmembrane transporter activity
F	0015662	molecular_function	P-type ion transporter activity
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0031004	cellular_component	potassium ion-transporting ATPase complex
F	0046872	molecular_function	metal ion binding
F	0071805	biological_process	potassium ion transmembrane transport
F	0098655	biological_process	monoatomic cation transmembrane transport
F	1903103	cellular_component	potassium:proton antiporter complex
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006813	biological_process	potassium ion transport
G	0008556	molecular_function	P-type potassium transmembrane transporter activity
G	0016020	cellular_component	membrane
G	0031004	cellular_component	potassium ion-transporting ATPase complex
G	0071805	biological_process	potassium ion transmembrane transport
G	0098655	biological_process	monoatomic cation transmembrane transport
G	1903103	cellular_component	potassium:proton antiporter complex
H	0005886	cellular_component	plasma membrane
H	0006813	biological_process	potassium ion transport
H	0008556	molecular_function	P-type potassium transmembrane transporter activity
H	0031004	cellular_component	potassium ion-transporting ATPase complex
H	0043462	biological_process	regulation of ATP-dependent activity
H	0071805	biological_process	potassium ion transmembrane transport
H	0098655	biological_process	monoatomic cation transmembrane transport
H	1903103	cellular_component	potassium:proton antiporter complex
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0006813	biological_process	potassium ion transport
I	0008556	molecular_function	P-type potassium transmembrane transporter activity
I	0030955	molecular_function	potassium ion binding
I	0031004	cellular_component	potassium ion-transporting ATPase complex
I	0071805	biological_process	potassium ion transmembrane transport
I	0098655	biological_process	monoatomic cation transmembrane transport
I	1903103	cellular_component	potassium:proton antiporter complex
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0005215	molecular_function	transporter activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005886	cellular_component	plasma membrane
J	0006813	biological_process	potassium ion transport
J	0008556	molecular_function	P-type potassium transmembrane transporter activity
J	0015662	molecular_function	P-type ion transporter activity
J	0016020	cellular_component	membrane
J	0016887	molecular_function	ATP hydrolysis activity
J	0031004	cellular_component	potassium ion-transporting ATPase complex
J	0046872	molecular_function	metal ion binding
J	0071805	biological_process	potassium ion transmembrane transport
J	0098655	biological_process	monoatomic cation transmembrane transport
J	1903103	cellular_component	potassium:proton antiporter complex
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005886	cellular_component	plasma membrane
K	0006813	biological_process	potassium ion transport
K	0008556	molecular_function	P-type potassium transmembrane transporter activity
K	0016020	cellular_component	membrane
K	0031004	cellular_component	potassium ion-transporting ATPase complex
K	0071805	biological_process	potassium ion transmembrane transport
K	0098655	biological_process	monoatomic cation transmembrane transport
K	1903103	cellular_component	potassium:proton antiporter complex
L	0005886	cellular_component	plasma membrane
L	0006813	biological_process	potassium ion transport
L	0008556	molecular_function	P-type potassium transmembrane transporter activity
L	0031004	cellular_component	potassium ion-transporting ATPase complex
L	0043462	biological_process	regulation of ATP-dependent activity
L	0071805	biological_process	potassium ion transmembrane transport
L	0098655	biological_process	monoatomic cation transmembrane transport
L	1903103	cellular_component	potassium:proton antiporter complex

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTIT

Chain	Residue	Details
B	ASP307-THR313

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	TRANSMEM: Helical => ECO:0000269|PubMed:28636601, ECO:0000269|PubMed:30478378, ECO:0007744|PDB:5MRW, ECO:0007744|PDB:6HRA

Chain	Residue	Details
C	PRO6-PHE34
F	ILE223-PHE242
F	VAL252-ILE263
F	LEU575-PHE595
F	PRO613-LEU631
F	LEU654-VAL678
J	PRO34-SER55
J	ALA62-ASN80
J	ILE223-PHE242
J	VAL252-ILE263
J	LEU575-PHE595
G	PRO6-PHE34
J	PRO613-LEU631
J	LEU654-VAL678
K	PRO6-PHE34
B	VAL252-ILE263
B	LEU575-PHE595
B	PRO613-LEU631
B	LEU654-VAL678
F	PRO34-SER55
F	ALA62-ASN80

---

site_id	SWS_FT_FI2
Number of Residues	465
Details	TOPO_DOM: Periplasmic => ECO:0000269|PubMed:28636601, ECO:0000269|PubMed:30478378

Chain	Residue	Details
C	PRO35-GLU190
J	SER243-SER251
J	ALA596-SER612
J	CYS679-VAL682
E	TYR126-PHE149
E	ALA166-GLN192
E	LEU250-ALA269
E	GLY280-TRP300
E	LEU357-ILE368
E	LYS415-ALA435
E	PHE480-MET501
G	PRO35-GLU190
E	PRO525-VAL552
I	ALA3-LEU27
I	TYR62-GLN84
I	TYR126-PHE149
I	ALA166-GLN192
I	LEU250-ALA269
I	GLY280-TRP300
I	LEU357-ILE368
I	LYS415-ALA435
I	PHE480-MET501
K	PRO35-GLU190
I	PRO525-VAL552
B	CYS679-VAL682
F	GLY56-ASN61
F	SER243-SER251
F	ALA596-SER612
F	CYS679-VAL682
J	GLY56-ASN61

---

site_id	SWS_FT_FI3
Number of Residues	1416
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28636601

Chain	Residue	Details
B	PHE81-THR222
E	ALA502-GLY524
I	ALA28-GLN61
I	ALA150-ASN165
I	PHE270-GLN279
I	GLY369-MET414
I	ALA502-GLY524
B	PRO264-SER574
B	ILE632-ASN653
F	PHE81-THR222
F	PRO264-SER574
F	ILE632-ASN653
J	PHE81-THR222
J	PRO264-SER574
J	ILE632-ASN653

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:1474895

Chain	Residue	Details
B	ASP307
F	ASP307
J	ASP307

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:16354672, ECO:0007744|PDB:2A00, ECO:0007744|PDB:2A29

Chain	Residue	Details
B	ASP344
B	PHE377
B	LYS395
F	ASP344
F	PHE377
F	LYS395
J	ASP344
J	PHE377
J	LYS395

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:16354672, ECO:0007744|PDB:2A00

Chain	Residue	Details
B	GLU348
F	GLU348
J	GLU348

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00285

Chain	Residue	Details
B	ASP518
B	ASP522
F	ASP518
F	ASP522
J	ASP518
J	ASP522

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28636601, ECO:0000269|PubMed:30478378

Chain	Residue	Details
B	SEP162
F	SEP162
J	SEP162

---