5MPS

Structure of a spliceosome remodeled for exon ligation

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
a	0000386	molecular_function	second spliceosomal transesterification activity
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0005634	cellular_component	nucleus
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0006397	biological_process	mRNA processing
a	0008380	biological_process	RNA splicing
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0071021	cellular_component	U2-type post-spliceosomal complex
a	0071028	biological_process	nuclear mRNA surveillance
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
A	0000386	molecular_function	second spliceosomal transesterification activity
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000389	biological_process	mRNA 3'-splice site recognition
A	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
A	0000395	biological_process	mRNA 5'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000974	cellular_component	Prp19 complex
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
A	1990904	cellular_component	ribonucleoprotein complex
b	0000245	biological_process	spliceosomal complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000395	biological_process	mRNA 5'-splice site recognition
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003674	molecular_function	molecular_function
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0032991	cellular_component	protein-containing complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0070990	molecular_function	snRNP binding
b	0071004	cellular_component	U2-type prespliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990904	cellular_component	ribonucleoprotein complex
c	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
c	0000386	molecular_function	second spliceosomal transesterification activity
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003676	molecular_function	nucleic acid binding
c	0005634	cellular_component	nucleus
c	0005681	cellular_component	spliceosomal complex
c	0006397	biological_process	mRNA processing
c	0008270	molecular_function	zinc ion binding
c	0008380	biological_process	RNA splicing
c	0030628	molecular_function	pre-mRNA 3'-splice site binding
c	0046872	molecular_function	metal ion binding
c	0071021	cellular_component	U2-type post-spliceosomal complex
C	0000166	molecular_function	nucleotide binding
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000974	cellular_component	Prp19 complex
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005682	cellular_component	U5 snRNP
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0000243	cellular_component	commitment complex
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000395	biological_process	mRNA 5'-splice site recognition
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0003729	molecular_function	mRNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006396	biological_process	RNA processing
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071004	cellular_component	U2-type prespliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
d	1990904	cellular_component	ribonucleoprotein complex
e	0000245	biological_process	spliceosomal complex assembly
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000395	biological_process	mRNA 5'-splice site recognition
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005737	cellular_component	cytoplasm
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0032991	cellular_component	protein-containing complex
e	0034715	cellular_component	pICln-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071004	cellular_component	U2-type prespliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
e	1990935	molecular_function	splicing factor binding
f	0000245	biological_process	spliceosomal complex assembly
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000395	biological_process	mRNA 5'-splice site recognition
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005737	cellular_component	cytoplasm
f	0006397	biological_process	mRNA processing
f	0008266	molecular_function	poly(U) RNA binding
f	0008380	biological_process	RNA splicing
f	0034715	cellular_component	pICln-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0120114	cellular_component	Sm-like protein family complex
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
f	1990935	molecular_function	splicing factor binding
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000395	biological_process	mRNA 5'-splice site recognition
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003674	molecular_function	molecular_function
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005737	cellular_component	cytoplasm
g	0006397	biological_process	mRNA processing
g	0008150	biological_process	biological_process
g	0008380	biological_process	RNA splicing
g	0032991	cellular_component	protein-containing complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071004	cellular_component	U2-type prespliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
h	0000243	cellular_component	commitment complex
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000395	biological_process	mRNA 5'-splice site recognition
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0003729	molecular_function	mRNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005682	cellular_component	U5 snRNP
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0071004	cellular_component	U2-type prespliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0097525	cellular_component	spliceosomal snRNP complex
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003674	molecular_function	molecular_function
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005681	cellular_component	spliceosomal complex
H	0005684	cellular_component	U2-type spliceosomal complex
H	0005737	cellular_component	cytoplasm
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0071013	cellular_component	catalytic step 2 spliceosome
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000395	biological_process	mRNA 5'-splice site recognition
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0000974	cellular_component	Prp19 complex
j	0003674	molecular_function	molecular_function
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008150	biological_process	biological_process
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034715	cellular_component	pICln-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071004	cellular_component	U2-type prespliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0000974	cellular_component	Prp19 complex
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0005737	cellular_component	cytoplasm
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0071013	cellular_component	catalytic step 2 spliceosome
K	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
K	0000384	molecular_function	first spliceosomal transesterification activity
K	0000386	molecular_function	second spliceosomal transesterification activity
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005681	cellular_component	spliceosomal complex
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0071006	cellular_component	U2-type catalytic step 1 spliceosome
K	0071007	cellular_component	U2-type catalytic step 2 spliceosome
K	0071014	cellular_component	post-mRNA release spliceosomal complex
L	0000282	biological_process	cellular bud site selection
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003674	molecular_function	molecular_function
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0005686	cellular_component	U2 snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
M	0000387	biological_process	spliceosomal snRNP assembly
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0003676	molecular_function	nucleic acid binding
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0006397	biological_process	mRNA processing
M	0008270	molecular_function	zinc ion binding
M	0008380	biological_process	RNA splicing
M	0017070	molecular_function	U6 snRNA binding
M	0033120	biological_process	positive regulation of RNA splicing
M	0036002	molecular_function	pre-mRNA binding
M	0045292	biological_process	mRNA cis splicing, via spliceosome
M	0045787	biological_process	positive regulation of cell cycle
M	0046872	molecular_function	metal ion binding
M	0071006	cellular_component	U2-type catalytic step 1 spliceosome
M	0071007	cellular_component	U2-type catalytic step 2 spliceosome
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0000974	cellular_component	Prp19 complex
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0017070	molecular_function	U6 snRNA binding
N	0036002	molecular_function	pre-mRNA binding
N	0071006	cellular_component	U2-type catalytic step 1 spliceosome
N	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0000348	biological_process	mRNA branch site recognition
o	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
o	0000386	molecular_function	second spliceosomal transesterification activity
o	0000389	biological_process	mRNA 3'-splice site recognition
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003729	molecular_function	mRNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005681	cellular_component	spliceosomal complex
o	0006397	biological_process	mRNA processing
o	0008380	biological_process	RNA splicing
o	0034399	cellular_component	nuclear periphery
o	0042802	molecular_function	identical protein binding
o	0071013	cellular_component	catalytic step 2 spliceosome
O	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
O	0000386	molecular_function	second spliceosomal transesterification activity
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005737	cellular_component	cytoplasm
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0071006	cellular_component	U2-type catalytic step 1 spliceosome
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003674	molecular_function	molecular_function
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005681	cellular_component	spliceosomal complex
P	0005684	cellular_component	U2-type spliceosomal complex
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003674	molecular_function	molecular_function
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005681	cellular_component	spliceosomal complex
R	0005684	cellular_component	U2-type spliceosomal complex
R	0005737	cellular_component	cytoplasm
R	0006397	biological_process	mRNA processing
R	0008380	biological_process	RNA splicing
S	0000245	biological_process	spliceosomal complex assembly
S	0000354	biological_process	cis assembly of pre-catalytic spliceosome
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000785	cellular_component	chromatin
S	0000974	cellular_component	Prp19 complex
S	0003682	molecular_function	chromatin binding
S	0003688	molecular_function	DNA replication origin binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005681	cellular_component	spliceosomal complex
S	0006270	biological_process	DNA replication initiation
S	0006396	biological_process	RNA processing
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0071004	cellular_component	U2-type prespliceosome
S	0071006	cellular_component	U2-type catalytic step 1 spliceosome
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
S	0071014	cellular_component	post-mRNA release spliceosomal complex
T	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
T	0000384	molecular_function	first spliceosomal transesterification activity
T	0000386	molecular_function	second spliceosomal transesterification activity
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000974	cellular_component	Prp19 complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005681	cellular_component	spliceosomal complex
T	0005829	cellular_component	cytosol
T	0006396	biological_process	RNA processing
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0071004	cellular_component	U2-type prespliceosome
T	0071006	cellular_component	U2-type catalytic step 1 spliceosome
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
T	0071014	cellular_component	post-mRNA release spliceosomal complex
y	0000384	molecular_function	first spliceosomal transesterification activity
y	0000386	molecular_function	second spliceosomal transesterification activity
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0000974	cellular_component	Prp19 complex
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005681	cellular_component	spliceosomal complex
y	0005829	cellular_component	cytosol
y	0006397	biological_process	mRNA processing
y	0008380	biological_process	RNA splicing
y	0071004	cellular_component	U2-type prespliceosome
y	0071006	cellular_component	U2-type catalytic step 1 spliceosome
y	0071007	cellular_component	U2-type catalytic step 2 spliceosome
y	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG 6 1001

Chain	Residue
6	G78
6	A79
6	U80

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG 6 1002

Chain	Residue
6	A59
6	G60
6	U80

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG 6 1003

Chain	Residue
6	G60
6	C61
6	G77

---

site_id	AC4
Number of Residues	2
Details	binding site for residue K 6 1004

Chain	Residue
6	A62
6	G81

---

site_id	AC5
Number of Residues	1
Details	binding site for residue K 6 1005

Chain	Residue
6	G81

---

site_id	AC6
Number of Residues	11
Details	binding site for residue IHP A 3001

Chain	Residue
A	ARG236
A	LYS517
A	HIS659
A	LYS684
A	HIS685
A	TYR688
A	TYR689
A	LYS697
A	GLY698
A	ASN1618
c	ARG170

---

site_id	AC7
Number of Residues	17
Details	binding site for residue GTP C 1101

Chain	Residue
A	ASN405
C	LEU142
C	HIS143
C	GLY145
C	LYS146
C	THR147
C	SER148
C	ARG176
C	LEU189
C	SER190
C	ALA215
C	GLY217
C	LYS269
C	ARG272
C	SER315
C	THR316
C	LYS317

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN L 1000

Chain	Residue
L	CYS104
L	CYS105
L	CYS108
L	CYS148

---

site_id	AC9
Number of Residues	6
Details	binding site for residue ZN L 1001

Chain	Residue
L	CYS104
L	CYS108
L	CYS122
L	CYS150
L	CYS153
L	ZN1002

---

site_id	AD1
Number of Residues	6
Details	binding site for residue ZN L 1002

Chain	Residue
L	CYS108
L	CYS120
L	CYS122
L	CYS145
L	CYS150
L	ZN1001

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN M 1000

Chain	Residue
M	CYS73
M	CYS81
M	CYS87
M	HIS91

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN N 401

Chain	Residue
N	CYS34
N	CYS37
N	CYS61
N	CYS64

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN N 402

Chain	Residue
N	CYS13
N	CYS16
N	CYS71
N	CYS74

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATAgrDsVIKLWDM

Chain	Residue	Details
J	ILE239-MET253
J	VAL281-VAL295
o	ILE178-PHE192

---

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqknEtNngstCiCRVP

Chain	Residue	Details
L	LEU103-PRO125

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CvHCGCRGCA

Chain	Residue	Details
L	CYS145-ALA154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	490
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	253
Details	Region: {"description":"RNase H homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	207
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	182
Details	Domain: {"description":"MIF4G","evidences":[{"source":"PROSITE-ProRule","id":"PRU00698","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	71
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	69
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	69
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	69
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	29
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	29
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	30
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	9
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	93
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	27
Details	Zinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	45
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	44
Details	Domain: {"description":"CWF21","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	37
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	15
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	10
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	32
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	32
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	31
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	31
Details	Repeat: {"description":"HAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	34
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	64
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	21
Details	Repeat: {"description":"HAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	72
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---