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5MP9

26S proteasome in presence of ATP (s1)

Functional Information from GO Data
ChainGOidnamespacecontents
10000502cellular_componentproteasome complex
10004175molecular_functionendopeptidase activity
10004298molecular_functionthreonine-type endopeptidase activity
10005515molecular_functionprotein binding
10005634cellular_componentnucleus
10005737cellular_componentcytoplasm
10005829cellular_componentcytosol
10005839cellular_componentproteasome core complex
10006508biological_processproteolysis
10010499biological_processproteasomal ubiquitin-independent protein catabolic process
10019774cellular_componentproteasome core complex, beta-subunit complex
10034515cellular_componentproteasome storage granule
10043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
10051603biological_processproteolysis involved in protein catabolic process
20000502cellular_componentproteasome complex
20004175molecular_functionendopeptidase activity
20004298molecular_functionthreonine-type endopeptidase activity
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005737cellular_componentcytoplasm
20005829cellular_componentcytosol
20005839cellular_componentproteasome core complex
20006508biological_processproteolysis
20010499biological_processproteasomal ubiquitin-independent protein catabolic process
20019774cellular_componentproteasome core complex, beta-subunit complex
20034515cellular_componentproteasome storage granule
20043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
20051603biological_processproteolysis involved in protein catabolic process
30000502cellular_componentproteasome complex
30005515molecular_functionprotein binding
30005634cellular_componentnucleus
30005737cellular_componentcytoplasm
30005829cellular_componentcytosol
30005839cellular_componentproteasome core complex
30010499biological_processproteasomal ubiquitin-independent protein catabolic process
30019774cellular_componentproteasome core complex, beta-subunit complex
30043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
30051603biological_processproteolysis involved in protein catabolic process
30061133molecular_functionendopeptidase activator activity
40000502cellular_componentproteasome complex
40005515molecular_functionprotein binding
40005634cellular_componentnucleus
40005737cellular_componentcytoplasm
40005789cellular_componentendoplasmic reticulum membrane
40005829cellular_componentcytosol
40005839cellular_componentproteasome core complex
40010498biological_processproteasomal protein catabolic process
40010499biological_processproteasomal ubiquitin-independent protein catabolic process
40019774cellular_componentproteasome core complex, beta-subunit complex
40043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
40051603biological_processproteolysis involved in protein catabolic process
40061133molecular_functionendopeptidase activator activity
50000502cellular_componentproteasome complex
50004175molecular_functionendopeptidase activity
50004298molecular_functionthreonine-type endopeptidase activity
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005737cellular_componentcytoplasm
50005777cellular_componentperoxisome
50005829cellular_componentcytosol
50005839cellular_componentproteasome core complex
50006508biological_processproteolysis
50010499biological_processproteasomal ubiquitin-independent protein catabolic process
50019774cellular_componentproteasome core complex, beta-subunit complex
50043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
50051603biological_processproteolysis involved in protein catabolic process
50080129biological_processproteasome core complex assembly
60000502cellular_componentproteasome complex
60003674molecular_functionmolecular_function
60005515molecular_functionprotein binding
60005634cellular_componentnucleus
60005737cellular_componentcytoplasm
60005829cellular_componentcytosol
60005839cellular_componentproteasome core complex
60010499biological_processproteasomal ubiquitin-independent protein catabolic process
60019774cellular_componentproteasome core complex, beta-subunit complex
60043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
60051603biological_processproteolysis involved in protein catabolic process
70000502cellular_componentproteasome complex
70003674molecular_functionmolecular_function
70005515molecular_functionprotein binding
70005634cellular_componentnucleus
70005737cellular_componentcytoplasm
70005829cellular_componentcytosol
70005839cellular_componentproteasome core complex
70010499biological_processproteasomal ubiquitin-independent protein catabolic process
70019774cellular_componentproteasome core complex, beta-subunit complex
70034515cellular_componentproteasome storage granule
70043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
70043248biological_processproteasome assembly
70051603biological_processproteolysis involved in protein catabolic process
A0000502cellular_componentproteasome complex
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0010499biological_processproteasomal ubiquitin-independent protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
B0000502cellular_componentproteasome complex
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0010499biological_processproteasomal ubiquitin-independent protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0034515cellular_componentproteasome storage granule
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051603biological_processproteolysis involved in protein catabolic process
C0000502cellular_componentproteasome complex
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0010499biological_processproteasomal ubiquitin-independent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0034515cellular_componentproteasome storage granule
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
C0080129biological_processproteasome core complex assembly
D0000502cellular_componentproteasome complex
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0010499biological_processproteasomal ubiquitin-independent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0034515cellular_componentproteasome storage granule
D0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0010499biological_processproteasomal ubiquitin-independent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0034515cellular_componentproteasome storage granule
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0003674molecular_functionmolecular_function
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0010499biological_processproteasomal ubiquitin-independent protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0034515cellular_componentproteasome storage granule
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0051603biological_processproteolysis involved in protein catabolic process
G0000502cellular_componentproteasome complex
G0003729molecular_functionmRNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005839cellular_componentproteasome core complex
G0006511biological_processubiquitin-dependent protein catabolic process
G0010499biological_processproteasomal ubiquitin-independent protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0034515cellular_componentproteasome storage granule
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0051603biological_processproteolysis involved in protein catabolic process
H0000502cellular_componentproteasome complex
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0006511biological_processubiquitin-dependent protein catabolic process
H0008540cellular_componentproteasome regulatory particle, base subcomplex
H0010604biological_processpositive regulation of macromolecule metabolic process
H0016887molecular_functionATP hydrolysis activity
H0031625molecular_functionubiquitin protein ligase binding
H0036402molecular_functionproteasome-activating activity
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0045732biological_processpositive regulation of protein catabolic process
H0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
H0070682biological_processproteasome regulatory particle assembly
H1901800biological_processpositive regulation of proteasomal protein catabolic process
I0000502cellular_componentproteasome complex
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0006511biological_processubiquitin-dependent protein catabolic process
I0008540cellular_componentproteasome regulatory particle, base subcomplex
I0010604biological_processpositive regulation of macromolecule metabolic process
I0016887molecular_functionATP hydrolysis activity
I0031503biological_processprotein-containing complex localization
I0036402molecular_functionproteasome-activating activity
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0043171biological_processpeptide catabolic process
I0045732biological_processpositive regulation of protein catabolic process
I0070651biological_processnonfunctional rRNA decay
I0070682biological_processproteasome regulatory particle assembly
I1901800biological_processpositive regulation of proteasomal protein catabolic process
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0006289biological_processnucleotide-excision repair
J0006338biological_processchromatin remodeling
J0008540cellular_componentproteasome regulatory particle, base subcomplex
J0010604biological_processpositive regulation of macromolecule metabolic process
J0016887molecular_functionATP hydrolysis activity
J0019904molecular_functionprotein domain specific binding
J0031625molecular_functionubiquitin protein ligase binding
J0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
J0034515cellular_componentproteasome storage granule
J0036402molecular_functionproteasome-activating activity
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
J0070651biological_processnonfunctional rRNA decay
J0070682biological_processproteasome regulatory particle assembly
J1901800biological_processpositive regulation of proteasomal protein catabolic process
K0000502cellular_componentproteasome complex
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0006511biological_processubiquitin-dependent protein catabolic process
K0008540cellular_componentproteasome regulatory particle, base subcomplex
K0010604biological_processpositive regulation of macromolecule metabolic process
K0016887molecular_functionATP hydrolysis activity
K0036402molecular_functionproteasome-activating activity
K0042802molecular_functionidentical protein binding
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
K0070682biological_processproteasome regulatory particle assembly
K1901800biological_processpositive regulation of proteasomal protein catabolic process
L0000502cellular_componentproteasome complex
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005634cellular_componentnucleus
L0006289biological_processnucleotide-excision repair
L0008540cellular_componentproteasome regulatory particle, base subcomplex
L0010604biological_processpositive regulation of macromolecule metabolic process
L0016887molecular_functionATP hydrolysis activity
L0019904molecular_functionprotein domain specific binding
L0031597cellular_componentcytosolic proteasome complex
L0031625molecular_functionubiquitin protein ligase binding
L0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
L0036402molecular_functionproteasome-activating activity
L0036503biological_processERAD pathway
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
L0070682biological_processproteasome regulatory particle assembly
L1901800biological_processpositive regulation of proteasomal protein catabolic process
M0000502cellular_componentproteasome complex
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0006511biological_processubiquitin-dependent protein catabolic process
M0008540cellular_componentproteasome regulatory particle, base subcomplex
M0010604biological_processpositive regulation of macromolecule metabolic process
M0016887molecular_functionATP hydrolysis activity
M0036402molecular_functionproteasome-activating activity
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
M0070682biological_processproteasome regulatory particle assembly
M1901800biological_processpositive regulation of proteasomal protein catabolic process
a0000502cellular_componentproteasome complex
a0003674molecular_functionmolecular_function
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005737cellular_componentcytoplasm
a0005739cellular_componentmitochondrion
a0005839cellular_componentproteasome core complex
a0006511biological_processubiquitin-dependent protein catabolic process
a0010499biological_processproteasomal ubiquitin-independent protein catabolic process
a0019773cellular_componentproteasome core complex, alpha-subunit complex
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a0051603biological_processproteolysis involved in protein catabolic process
b0000502cellular_componentproteasome complex
b0003674molecular_functionmolecular_function
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005737cellular_componentcytoplasm
b0005839cellular_componentproteasome core complex
b0006511biological_processubiquitin-dependent protein catabolic process
b0010499biological_processproteasomal ubiquitin-independent protein catabolic process
b0019773cellular_componentproteasome core complex, alpha-subunit complex
b0034515cellular_componentproteasome storage granule
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0051603biological_processproteolysis involved in protein catabolic process
c0000502cellular_componentproteasome complex
c0003674molecular_functionmolecular_function
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0005839cellular_componentproteasome core complex
c0006511biological_processubiquitin-dependent protein catabolic process
c0010499biological_processproteasomal ubiquitin-independent protein catabolic process
c0019773cellular_componentproteasome core complex, alpha-subunit complex
c0034515cellular_componentproteasome storage granule
c0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
c0051603biological_processproteolysis involved in protein catabolic process
c0080129biological_processproteasome core complex assembly
d0000502cellular_componentproteasome complex
d0003674molecular_functionmolecular_function
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005737cellular_componentcytoplasm
d0005739cellular_componentmitochondrion
d0005839cellular_componentproteasome core complex
d0006511biological_processubiquitin-dependent protein catabolic process
d0010499biological_processproteasomal ubiquitin-independent protein catabolic process
d0019773cellular_componentproteasome core complex, alpha-subunit complex
d0034515cellular_componentproteasome storage granule
d0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
d0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
d0051603biological_processproteolysis involved in protein catabolic process
e0000502cellular_componentproteasome complex
e0003674molecular_functionmolecular_function
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005737cellular_componentcytoplasm
e0005839cellular_componentproteasome core complex
e0006511biological_processubiquitin-dependent protein catabolic process
e0010499biological_processproteasomal ubiquitin-independent protein catabolic process
e0019773cellular_componentproteasome core complex, alpha-subunit complex
e0034515cellular_componentproteasome storage granule
e0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
e0051603biological_processproteolysis involved in protein catabolic process
f0000502cellular_componentproteasome complex
f0003674molecular_functionmolecular_function
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005737cellular_componentcytoplasm
f0005839cellular_componentproteasome core complex
f0006511biological_processubiquitin-dependent protein catabolic process
f0010499biological_processproteasomal ubiquitin-independent protein catabolic process
f0019773cellular_componentproteasome core complex, alpha-subunit complex
f0034515cellular_componentproteasome storage granule
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0051603biological_processproteolysis involved in protein catabolic process
g0000502cellular_componentproteasome complex
g0003729molecular_functionmRNA binding
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0005737cellular_componentcytoplasm
g0005839cellular_componentproteasome core complex
g0006511biological_processubiquitin-dependent protein catabolic process
g0010499biological_processproteasomal ubiquitin-independent protein catabolic process
g0019773cellular_componentproteasome core complex, alpha-subunit complex
g0034515cellular_componentproteasome storage granule
g0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
g0051603biological_processproteolysis involved in protein catabolic process
h0000502cellular_componentproteasome complex
h0004175molecular_functionendopeptidase activity
h0004298molecular_functionthreonine-type endopeptidase activity
h0005515molecular_functionprotein binding
h0005634cellular_componentnucleus
h0005737cellular_componentcytoplasm
h0005829cellular_componentcytosol
h0005839cellular_componentproteasome core complex
h0006508biological_processproteolysis
h0010499biological_processproteasomal ubiquitin-independent protein catabolic process
h0019774cellular_componentproteasome core complex, beta-subunit complex
h0034515cellular_componentproteasome storage granule
h0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
h0051603biological_processproteolysis involved in protein catabolic process
i0000502cellular_componentproteasome complex
i0004175molecular_functionendopeptidase activity
i0004298molecular_functionthreonine-type endopeptidase activity
i0005515molecular_functionprotein binding
i0005634cellular_componentnucleus
i0005737cellular_componentcytoplasm
i0005829cellular_componentcytosol
i0005839cellular_componentproteasome core complex
i0006508biological_processproteolysis
i0010499biological_processproteasomal ubiquitin-independent protein catabolic process
i0019774cellular_componentproteasome core complex, beta-subunit complex
i0034515cellular_componentproteasome storage granule
i0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
i0051603biological_processproteolysis involved in protein catabolic process
j0000502cellular_componentproteasome complex
j0005515molecular_functionprotein binding
j0005634cellular_componentnucleus
j0005737cellular_componentcytoplasm
j0005829cellular_componentcytosol
j0005839cellular_componentproteasome core complex
j0010499biological_processproteasomal ubiquitin-independent protein catabolic process
j0019774cellular_componentproteasome core complex, beta-subunit complex
j0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
j0051603biological_processproteolysis involved in protein catabolic process
j0061133molecular_functionendopeptidase activator activity
k0000502cellular_componentproteasome complex
k0005515molecular_functionprotein binding
k0005634cellular_componentnucleus
k0005737cellular_componentcytoplasm
k0005789cellular_componentendoplasmic reticulum membrane
k0005829cellular_componentcytosol
k0005839cellular_componentproteasome core complex
k0010498biological_processproteasomal protein catabolic process
k0010499biological_processproteasomal ubiquitin-independent protein catabolic process
k0019774cellular_componentproteasome core complex, beta-subunit complex
k0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
k0051603biological_processproteolysis involved in protein catabolic process
k0061133molecular_functionendopeptidase activator activity
l0000502cellular_componentproteasome complex
l0004175molecular_functionendopeptidase activity
l0004298molecular_functionthreonine-type endopeptidase activity
l0005515molecular_functionprotein binding
l0005634cellular_componentnucleus
l0005737cellular_componentcytoplasm
l0005777cellular_componentperoxisome
l0005829cellular_componentcytosol
l0005839cellular_componentproteasome core complex
l0006508biological_processproteolysis
l0010499biological_processproteasomal ubiquitin-independent protein catabolic process
l0019774cellular_componentproteasome core complex, beta-subunit complex
l0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
l0051603biological_processproteolysis involved in protein catabolic process
l0080129biological_processproteasome core complex assembly
m0000502cellular_componentproteasome complex
m0003674molecular_functionmolecular_function
m0005515molecular_functionprotein binding
m0005634cellular_componentnucleus
m0005737cellular_componentcytoplasm
m0005829cellular_componentcytosol
m0005839cellular_componentproteasome core complex
m0010499biological_processproteasomal ubiquitin-independent protein catabolic process
m0019774cellular_componentproteasome core complex, beta-subunit complex
m0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
m0051603biological_processproteolysis involved in protein catabolic process
n0000502cellular_componentproteasome complex
n0003674molecular_functionmolecular_function
n0005515molecular_functionprotein binding
n0005634cellular_componentnucleus
n0005737cellular_componentcytoplasm
n0005829cellular_componentcytosol
n0005839cellular_componentproteasome core complex
n0010499biological_processproteasomal ubiquitin-independent protein catabolic process
n0019774cellular_componentproteasome core complex, beta-subunit complex
n0034515cellular_componentproteasome storage granule
n0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
n0043248biological_processproteasome assembly
n0051603biological_processproteolysis involved in protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue ATP H 501
ChainResidue
HASP210
HASN356
HHIS392
HMG502
IASP314
IARG340
IARG343
HGLY212
HPRO252
HGLY253
HTHR254
HGLY255
HLYS256
HTHR257
HLEU258

site_idAC2
Number of Residues2
Detailsbinding site for residue MG H 502
ChainResidue
HTHR257
HATP501

site_idAC3
Number of Residues17
Detailsbinding site for residue ATP I 501
ChainResidue
IASP183
IGLY185
ILEU187
IPRO225
IGLY226
ITHR227
IGLY228
ILYS229
ITHR230
ILEU231
IILE361
IHIS365
IGLY389
IALA390
IGLN393
IMG502
JARG306

site_idAC4
Number of Residues2
Detailsbinding site for residue MG I 502
ChainResidue
ITHR230
IATP501

site_idAC5
Number of Residues12
Detailsbinding site for residue ATP K 501
ChainResidue
KGLY175
KPRO215
KGLY216
KTHR217
KGLY218
KLYS219
KTHR220
KMET221
KASN319
KGLY380
KMG502
LARG342

site_idAC6
Number of Residues2
Detailsbinding site for residue MG K 502
ChainResidue
KTHR220
KATP501

site_idAC7
Number of Residues19
Detailsbinding site for residue ATP L 501
ChainResidue
LGLY184
LLEU186
LGLY225
LTHR226
LGLY227
LLYS228
LTHR229
LLEU230
LGLU282
LASN328
LILE360
LHIS364
LGLY388
LALA389
LARG392
LMG502
MASP313
MARG339
MARG342

site_idAC8
Number of Residues2
Detailsbinding site for residue MG L 502
ChainResidue
LTHR229
LATP501

site_idAC9
Number of Residues18
Detailsbinding site for residue ATP M 501
ChainResidue
HARG367
HARG370
MGLY184
MLEU186
MPRO224
MGLY225
MTHR226
MGLY227
MLYS228
MTHR229
MLEU230
MGLU282
MASN328
MHIS364
MGLY388
MALA389
MLYS392
MMG502

site_idAD1
Number of Residues2
Detailsbinding site for residue MG M 502
ChainResidue
MTHR229
MATP501

site_idAD2
Number of Residues16
Detailsbinding site for residue ADP J 501
ChainResidue
JTHR196
JLEU197
JARG200
JILE327
JHIS331
JGLY355
JLYS359
JMG502
JMET149
JVAL150
JLEU153
JPRO191
JGLY192
JTHR193
JGLY194
JLYS195

site_idAD3
Number of Residues2
Detailsbinding site for residue MG J 502
ChainResidue
JTHR196
JADP501

Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlgQIDYAltA
ChainResidueDetails
bTYR5-ALA27
dTYR2-ALA24
aTYR3-ALA25
cTYR5-SER27
eTYR0-ALA22
fTYR5-ALA27
gTYR4-ALA26

site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IkIImATNrldiLDpALl.R
ChainResidueDetails
JILE288-ARG306
MVAL321-ARG339
IVAL322-ARG340
KVAL312-ARG330
LTHR321-ARG339
HILE349-ARG367

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD
ChainResidueDetails
dVAL32-ASP79
kLEU5-ASP52
6LEU13-ASP60
cILE35-ASP82
jVAL12-ASP58
iVAL4-ASP51
7ILE12-ASP59
hMET4-ASP51
lLEU4-ASP51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING:
ChainResidueDetails
JGLY189
5THR1
cLYS198
cLYS230
CLYS99
CLYS198
CLYS230

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylthreonine => ECO:0000269|PubMed:12504901
ChainResidueDetails
JTHR2
HSER231
3LYS69

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19779198
ChainResidueDetails
MTYR180
ESER243
ILYS255
ILYS290

Catalytic Information from CSA
site_idMCSA1
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
iTHR1covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
iASP17activator, steric locator
iARG19activator
iLYS33activator, electrostatic stabiliser
iGLY47electrostatic stabiliser
iSER129activator, electrostatic stabiliser
iASP166activator, steric locator
iSER169activator, electrostatic stabiliser

site_idMCSA2
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
2THR1covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
2ASP17activator, steric locator
2ARG19activator
2LYS33activator, electrostatic stabiliser
2GLY47electrostatic stabiliser
2SER129activator, electrostatic stabiliser
2ASP166activator, steric locator
2SER169activator, electrostatic stabiliser

226707

PDB entries from 2024-10-30

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