5MP7

Crystal structure of phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0044249	biological_process	cellular biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004749	molecular_function	ribose phosphate diphosphokinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
B	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0044249	biological_process	cellular biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004749	molecular_function	ribose phosphate diphosphokinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
C	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0044249	biological_process	cellular biosynthetic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 401

Chain	Residue
A	ASP234
A	THR235
A	GLY236
A	GLY237
A	THR238

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site_id	AC2
Number of Residues	5
Details	binding site for residue ACT C 401

Chain	Residue
C	THR238
B	GLN269
C	ASP234
C	THR235
C	GLY236

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site_id	AC3
Number of Residues	3
Details	binding site for residue ACT B 401

Chain	Residue
B	ASP234
B	THR235
B	THR238

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site_id	AC4
Number of Residues	13
Details	binding site for Di-peptide ARG B 181 and ASP B 231

Chain	Residue
B	HIS138
B	SER176
B	ASP178
B	SER179
B	GLY180
B	VAL182
B	ARG183
B	VAL184
B	ALA185
B	ASP230
B	MET232
B	THR259
B	HIS260

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Functional Information from PROSITE/UniProt

site_id	PS00114
Number of Residues	16
Details	PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHTdQIQGFFdgPVD

Chain	Residue	Details
A	ASP136-ASP151

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site_id	PS00144
Number of Residues	9
Details	ASN_GLN_ASE_1 Asparaginase / glutaminase active site signature 1. MiDTGGTIA

Chain	Residue	Details
A	MET232-ALA240

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