5MP3

Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0046872	molecular_function	metal ion binding
C	0008017	molecular_function	microtubule binding
C	0015631	molecular_function	tubulin binding
D	0008017	molecular_function	microtubule binding
D	0015631	molecular_function	tubulin binding
L	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSkdNikHvPGGG

Chain	Residue	Details
C	GLY292-GLY304

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR197-HIS203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	SITE: Not glycated => ECO:0000269|PubMed:9326300

Chain	Residue	Details
C	LYS294
D	LYS321
C	LYS298
C	LYS311
C	LYS317
C	LYS321
D	LYS294
D	LYS298
D	LYS311
D	LYS317

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:7706316

Chain	Residue	Details
C	SER293
D	SER293

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
C	LYS298
C	LYS311
C	LYS317
C	LYS321
D	LYS298
D	LYS311
D	LYS317
D	LYS321

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860

Chain	Residue	Details
C	SER305
D	SER305

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
C	LYS298
C	LYS317
C	LYS321
D	LYS298
D	LYS317
D	LYS321

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603

Chain	Residue	Details
C	LYS311
D	LYS311

---