5MP3

Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0019814	cellular_component	immunoglobulin complex
B	0046872	molecular_function	metal ion binding
C	0008017	molecular_function	microtubule binding
C	0015631	molecular_function	tubulin binding
D	0008017	molecular_function	microtubule binding
D	0015631	molecular_function	tubulin binding
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0019814	cellular_component	immunoglobulin complex
L	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSkdNikHvPGGG

Chain	Residue	Details
C	GLY292-GLY304

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR197-HIS203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI11
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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