5MP1
Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| A | LYS298 | |
| A | LYS311 | |
| B | LYS298 | |
| B | LYS311 | |
| E | LYS298 | |
| E | LYS311 | |
| I | LYS298 | |
| I | LYS311 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| A | LYS298 | |
| A | LYS311 | |
| B | LYS298 | |
| B | LYS311 | |
| E | LYS298 | |
| E | LYS311 | |
| I | LYS298 | |
| I | LYS311 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860 |
| Chain | Residue | Details |
| A | SER305 | |
| B | SER305 | |
| E | SER305 | |
| I | SER305 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| A | LYS298 | |
| B | LYS298 | |
| E | LYS298 | |
| I | LYS298 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| A | LYS311 | |
| B | LYS311 | |
| E | LYS311 | |
| I | LYS311 |
