5MM1
Dolichyl phosphate mannose synthase in complex with GDP and dolichyl phosphate mannose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000271 | biological_process | polysaccharide biosynthetic process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004582 | molecular_function | dolichyl-phosphate beta-D-mannosyltransferase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006486 | biological_process | protein glycosylation |
| A | 0006488 | biological_process | dolichol-linked oligosaccharide biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0019348 | biological_process | dolichol metabolic process |
| A | 0035269 | biological_process | protein O-linked mannosylation |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue GDP A 500 |
| Chain | Residue |
| A | PRO8 |
| A | ALA90 |
| A | MJC501 |
| A | THR9 |
| A | TYR10 |
| A | GLU12 |
| A | VAL37 |
| A | ASP39 |
| A | GLY68 |
| A | LEU69 |
| A | ASP89 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue MJC A 501 |
| Chain | Residue |
| A | ASP89 |
| A | HIS94 |
| A | ARG117 |
| A | ARG131 |
| A | ILE134 |
| A | SER135 |
| A | ALA138 |
| A | MET140 |
| A | VAL141 |
| A | ALA145 |
| A | VAL156 |
| A | SER157 |
| A | GLY158 |
| A | LYS178 |
| A | PHE199 |
| A | ILE214 |
| A | ILE318 |
| A | GLY339 |
| A | VAL340 |
| A | GDP500 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 235 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-GLY229 | |
| A | LYS287-SER293 | |
| A | ALA351-THR352 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:28743912 |
| Chain | Residue | Details |
| A | GLU230-VAL256 | |
| A | LYS262-PHE286 | |
| A | ILE294-LEU320 | |
| A | TYR326-TRP350 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ASN257-PRO261 | |
| A | PHE321-HIS325 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28743912, ECO:0007744|PDB:5MLZ, ECO:0007744|PDB:5MM0, ECO:0007744|PDB:5MM1 |
| Chain | Residue | Details |
| A | PRO8 | |
| A | TYR10 | |
| A | VAL37 | |
| A | ASP39 | |
| A | ALA90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28743912, ECO:0007744|PDB:5MM0 |
| Chain | Residue | Details |
| A | GLU12 | |
| A | ASP89 | |
| A | ASP91 | |
| A | GLN93 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28743912, ECO:0007744|PDB:5MM0, ECO:0007744|PDB:5MM1 |
| Chain | Residue | Details |
| A | ARG117 | |
| A | VAL156 | |
| A | LYS178 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28743912, ECO:0007744|PDB:5MLZ, ECO:0007744|PDB:5MM0 |
| Chain | Residue | Details |
| A | ARG202 | |
| A | LYS208 |
