5MLZ

Dolichyl phosphate mannose synthase in complex with GDP and Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000271	biological_process	polysaccharide biosynthetic process
A	0000287	molecular_function	magnesium ion binding
A	0004582	molecular_function	dolichyl-phosphate beta-D-mannosyltransferase activity
A	0005886	cellular_component	plasma membrane
A	0006486	biological_process	obsolete protein glycosylation
A	0006488	biological_process	dolichol-linked oligosaccharide biosynthetic process
A	0006506	biological_process	GPI anchor biosynthetic process
A	0008654	biological_process	phospholipid biosynthetic process
A	0009101	biological_process	glycoprotein biosynthetic process
A	0009247	biological_process	glycolipid biosynthetic process
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0030145	molecular_function	manganese ion binding
A	0035269	biological_process	protein O-linked glycosylation via mannose
A	0046872	molecular_function	metal ion binding
A	0180047	biological_process	dolichol phosphate mannose biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue GDP A 401

Chain	Residue
A	PRO8
A	ASP89
A	ALA90
A	ASP91
A	GLN93
A	ARG202
A	SER207
A	LYS208
A	MG402
A	THR9
A	TYR10
A	GLU12
A	VAL37
A	ASP39
A	GLY68
A	LEU69
A	ALA72

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	ASP91
A	GLN93
A	ARG202
A	GDP401

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 403

Chain	Residue
A	ASN277
A	PHE301
A	ARG341

---

site_id	AC4
Number of Residues	5
Details	binding site for residue LDA A 404

Chain	Residue
A	SER243
A	ASN276
A	TRP280
A	TRP280
A	TRP284

---

site_id	AC5
Number of Residues	4
Details	binding site for residue LDA A 405

Chain	Residue
A	GLU249
A	GLY250
A	PHE251
A	TRP253

---

site_id	AC6
Number of Residues	3
Details	binding site for residue LDA A 406

Chain	Residue
A	TRP317
A	VAL343
A	HIS347

---

site_id	AC7
Number of Residues	7
Details	binding site for residue LDA A 408

Chain	Residue
A	GLY244
A	VAL270
A	SER273
A	ASN277
A	LEU306
A	LEU306
A	LDA409

---

site_id	AC8
Number of Residues	3
Details	binding site for residue LDA A 409

Chain	Residue
A	VAL270
A	GLU271
A	LDA408

---

site_id	AC9
Number of Residues	1
Details	binding site for residue LDA A 410

Chain	Residue
A	TYR222

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	235
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	100
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---