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5MKE

cryoEM Structure of Polycystin-2 in complex with cations and lipids

Functional Information from GO Data
ChainGOidnamespacecontents
A0001658biological_processbranching involved in ureteric bud morphogenesis
A0001822biological_processkidney development
A0001889biological_processliver development
A0001892biological_processembryonic placenta development
A0001947biological_processheart looping
A0002133cellular_componentpolycystin complex
A0003127biological_processdetection of nodal flow
A0005102molecular_functionsignaling receptor binding
A0005244molecular_functionvoltage-gated monoatomic ion channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005248molecular_functionvoltage-gated sodium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005267molecular_functionpotassium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005929cellular_componentcilium
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0007166biological_processcell surface receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0007368biological_processdetermination of left/right symmetry
A0007507biological_processheart development
A0008092molecular_functioncytoskeletal protein binding
A0008285biological_processnegative regulation of cell population proliferation
A0009925cellular_componentbasal plasma membrane
A0010628biological_processpositive regulation of gene expression
A0015267molecular_functionchannel activity
A0015271molecular_functionoutward rectifier potassium channel activity
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016323cellular_componentbasolateral plasma membrane
A0019722biological_processcalcium-mediated signaling
A0021510biological_processspinal cord development
A0021915biological_processneural tube development
A0022843molecular_functionvoltage-gated monoatomic cation channel activity
A0030027cellular_componentlamellipodium
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031587biological_processpositive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
A0031982cellular_componentvesicle
A0034614biological_processcellular response to reactive oxygen species
A0034702cellular_componentmonoatomic ion channel complex
A0034703cellular_componentcation channel complex
A0035502biological_processmetanephric part of ureteric bud development
A0035725biological_processsodium ion transmembrane transport
A0035904biological_processaorta development
A0036064cellular_componentciliary basal body
A0042127biological_processregulation of cell population proliferation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042805molecular_functionactinin binding
A0043226cellular_componentorganelle
A0043398molecular_functionHLH domain binding
A0044325molecular_functiontransmembrane transporter binding
A0044782biological_processcilium organization
A0045180cellular_componentbasal cortex
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0048763molecular_functioncalcium-induced calcium release activity
A0050982biological_processdetection of mechanical stimulus
A0051117molecular_functionATPase binding
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051219molecular_functionphosphoprotein binding
A0051262biological_processprotein tetramerization
A0051289biological_processprotein homotetramerization
A0051290biological_processprotein heterotetramerization
A0051298biological_processcentrosome duplication
A0051371molecular_functionmuscle alpha-actinin binding
A0051393molecular_functionalpha-actinin binding
A0051649biological_processestablishment of localization in cell
A0051726biological_processregulation of cell cycle
A0060170cellular_componentciliary membrane
A0060674biological_processplacenta blood vessel development
A0061333biological_processrenal tubule morphogenesis
A0061441biological_processrenal artery morphogenesis
A0070062cellular_componentextracellular exosome
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071320biological_processcellular response to cAMP
A0071464biological_processcellular response to hydrostatic pressure
A0071470biological_processcellular response to osmotic stress
A0071498biological_processcellular response to fluid shear stress
A0071805biological_processpotassium ion transmembrane transport
A0071910biological_processdetermination of liver left/right asymmetry
A0072075biological_processmetanephric mesenchyme development
A0072164biological_processmesonephric tubule development
A0072177biological_processmesonephric duct development
A0072208biological_processmetanephric smooth muscle tissue development
A0072214biological_processmetanephric cortex development
A0072218biological_processmetanephric ascending thin limb development
A0072219biological_processmetanephric cortical collecting duct development
A0072235biological_processmetanephric distal tubule development
A0072284biological_processmetanephric S-shaped body morphogenesis
A0072686cellular_componentmitotic spindle
A0090279biological_processregulation of calcium ion import
A0097730cellular_componentnon-motile cilium
A0098553cellular_componentlumenal side of endoplasmic reticulum membrane
A0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
A0098662biological_processinorganic cation transmembrane transport
A0140416molecular_functiontranscription regulator inhibitor activity
A0140494cellular_componentmigrasome
A2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
B0001658biological_processbranching involved in ureteric bud morphogenesis
B0001822biological_processkidney development
B0001889biological_processliver development
B0001892biological_processembryonic placenta development
B0001947biological_processheart looping
B0002133cellular_componentpolycystin complex
B0003127biological_processdetection of nodal flow
B0005102molecular_functionsignaling receptor binding
B0005244molecular_functionvoltage-gated monoatomic ion channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005248molecular_functionvoltage-gated sodium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005267molecular_functionpotassium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005929cellular_componentcilium
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0007166biological_processcell surface receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0007368biological_processdetermination of left/right symmetry
B0007507biological_processheart development
B0008092molecular_functioncytoskeletal protein binding
B0008285biological_processnegative regulation of cell population proliferation
B0009925cellular_componentbasal plasma membrane
B0010628biological_processpositive regulation of gene expression
B0015267molecular_functionchannel activity
B0015271molecular_functionoutward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0016055biological_processWnt signaling pathway
B0016323cellular_componentbasolateral plasma membrane
B0019722biological_processcalcium-mediated signaling
B0021510biological_processspinal cord development
B0021915biological_processneural tube development
B0022843molecular_functionvoltage-gated monoatomic cation channel activity
B0030027cellular_componentlamellipodium
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031514cellular_componentmotile cilium
B0031587biological_processpositive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
B0031982cellular_componentvesicle
B0034614biological_processcellular response to reactive oxygen species
B0034702cellular_componentmonoatomic ion channel complex
B0034703cellular_componentcation channel complex
B0035502biological_processmetanephric part of ureteric bud development
B0035725biological_processsodium ion transmembrane transport
B0035904biological_processaorta development
B0036064cellular_componentciliary basal body
B0042127biological_processregulation of cell population proliferation
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042805molecular_functionactinin binding
B0043226cellular_componentorganelle
B0043398molecular_functionHLH domain binding
B0044325molecular_functiontransmembrane transporter binding
B0044782biological_processcilium organization
B0045180cellular_componentbasal cortex
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0048763molecular_functioncalcium-induced calcium release activity
B0050982biological_processdetection of mechanical stimulus
B0051117molecular_functionATPase binding
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051219molecular_functionphosphoprotein binding
B0051262biological_processprotein tetramerization
B0051289biological_processprotein homotetramerization
B0051290biological_processprotein heterotetramerization
B0051298biological_processcentrosome duplication
B0051371molecular_functionmuscle alpha-actinin binding
B0051393molecular_functionalpha-actinin binding
B0051649biological_processestablishment of localization in cell
B0051726biological_processregulation of cell cycle
B0060170cellular_componentciliary membrane
B0060674biological_processplacenta blood vessel development
B0061333biological_processrenal tubule morphogenesis
B0061441biological_processrenal artery morphogenesis
B0070062cellular_componentextracellular exosome
B0070588biological_processcalcium ion transmembrane transport
B0071277biological_processcellular response to calcium ion
B0071320biological_processcellular response to cAMP
B0071464biological_processcellular response to hydrostatic pressure
B0071470biological_processcellular response to osmotic stress
B0071498biological_processcellular response to fluid shear stress
B0071805biological_processpotassium ion transmembrane transport
B0071910biological_processdetermination of liver left/right asymmetry
B0072075biological_processmetanephric mesenchyme development
B0072164biological_processmesonephric tubule development
B0072177biological_processmesonephric duct development
B0072208biological_processmetanephric smooth muscle tissue development
B0072214biological_processmetanephric cortex development
B0072218biological_processmetanephric ascending thin limb development
B0072219biological_processmetanephric cortical collecting duct development
B0072235biological_processmetanephric distal tubule development
B0072284biological_processmetanephric S-shaped body morphogenesis
B0072686cellular_componentmitotic spindle
B0090279biological_processregulation of calcium ion import
B0097730cellular_componentnon-motile cilium
B0098553cellular_componentlumenal side of endoplasmic reticulum membrane
B0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
B0098662biological_processinorganic cation transmembrane transport
B0140416molecular_functiontranscription regulator inhibitor activity
B0140494cellular_componentmigrasome
B2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
C0001658biological_processbranching involved in ureteric bud morphogenesis
C0001822biological_processkidney development
C0001889biological_processliver development
C0001892biological_processembryonic placenta development
C0001947biological_processheart looping
C0002133cellular_componentpolycystin complex
C0003127biological_processdetection of nodal flow
C0005102molecular_functionsignaling receptor binding
C0005244molecular_functionvoltage-gated monoatomic ion channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005248molecular_functionvoltage-gated sodium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005267molecular_functionpotassium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005929cellular_componentcilium
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0007166biological_processcell surface receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0007368biological_processdetermination of left/right symmetry
C0007507biological_processheart development
C0008092molecular_functioncytoskeletal protein binding
C0008285biological_processnegative regulation of cell population proliferation
C0009925cellular_componentbasal plasma membrane
C0010628biological_processpositive regulation of gene expression
C0015267molecular_functionchannel activity
C0015271molecular_functionoutward rectifier potassium channel activity
C0016020cellular_componentmembrane
C0016055biological_processWnt signaling pathway
C0016323cellular_componentbasolateral plasma membrane
C0019722biological_processcalcium-mediated signaling
C0021510biological_processspinal cord development
C0021915biological_processneural tube development
C0022843molecular_functionvoltage-gated monoatomic cation channel activity
C0030027cellular_componentlamellipodium
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0031514cellular_componentmotile cilium
C0031587biological_processpositive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
C0031982cellular_componentvesicle
C0034614biological_processcellular response to reactive oxygen species
C0034702cellular_componentmonoatomic ion channel complex
C0034703cellular_componentcation channel complex
C0035502biological_processmetanephric part of ureteric bud development
C0035725biological_processsodium ion transmembrane transport
C0035904biological_processaorta development
C0036064cellular_componentciliary basal body
C0042127biological_processregulation of cell population proliferation
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042805molecular_functionactinin binding
C0043226cellular_componentorganelle
C0043398molecular_functionHLH domain binding
C0044325molecular_functiontransmembrane transporter binding
C0044782biological_processcilium organization
C0045180cellular_componentbasal cortex
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046872molecular_functionmetal ion binding
C0048763molecular_functioncalcium-induced calcium release activity
C0050982biological_processdetection of mechanical stimulus
C0051117molecular_functionATPase binding
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051219molecular_functionphosphoprotein binding
C0051262biological_processprotein tetramerization
C0051289biological_processprotein homotetramerization
C0051290biological_processprotein heterotetramerization
C0051298biological_processcentrosome duplication
C0051371molecular_functionmuscle alpha-actinin binding
C0051393molecular_functionalpha-actinin binding
C0051649biological_processestablishment of localization in cell
C0051726biological_processregulation of cell cycle
C0060170cellular_componentciliary membrane
C0060674biological_processplacenta blood vessel development
C0061333biological_processrenal tubule morphogenesis
C0061441biological_processrenal artery morphogenesis
C0070062cellular_componentextracellular exosome
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071320biological_processcellular response to cAMP
C0071464biological_processcellular response to hydrostatic pressure
C0071470biological_processcellular response to osmotic stress
C0071498biological_processcellular response to fluid shear stress
C0071805biological_processpotassium ion transmembrane transport
C0071910biological_processdetermination of liver left/right asymmetry
C0072075biological_processmetanephric mesenchyme development
C0072164biological_processmesonephric tubule development
C0072177biological_processmesonephric duct development
C0072208biological_processmetanephric smooth muscle tissue development
C0072214biological_processmetanephric cortex development
C0072218biological_processmetanephric ascending thin limb development
C0072219biological_processmetanephric cortical collecting duct development
C0072235biological_processmetanephric distal tubule development
C0072284biological_processmetanephric S-shaped body morphogenesis
C0072686cellular_componentmitotic spindle
C0090279biological_processregulation of calcium ion import
C0097730cellular_componentnon-motile cilium
C0098553cellular_componentlumenal side of endoplasmic reticulum membrane
C0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
C0098662biological_processinorganic cation transmembrane transport
C0140416molecular_functiontranscription regulator inhibitor activity
C0140494cellular_componentmigrasome
C2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
D0001658biological_processbranching involved in ureteric bud morphogenesis
D0001822biological_processkidney development
D0001889biological_processliver development
D0001892biological_processembryonic placenta development
D0001947biological_processheart looping
D0002133cellular_componentpolycystin complex
D0003127biological_processdetection of nodal flow
D0005102molecular_functionsignaling receptor binding
D0005244molecular_functionvoltage-gated monoatomic ion channel activity
D0005245molecular_functionvoltage-gated calcium channel activity
D0005248molecular_functionvoltage-gated sodium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005267molecular_functionpotassium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005929cellular_componentcilium
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0007166biological_processcell surface receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0007368biological_processdetermination of left/right symmetry
D0007507biological_processheart development
D0008092molecular_functioncytoskeletal protein binding
D0008285biological_processnegative regulation of cell population proliferation
D0009925cellular_componentbasal plasma membrane
D0010628biological_processpositive regulation of gene expression
D0015267molecular_functionchannel activity
D0015271molecular_functionoutward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0016055biological_processWnt signaling pathway
D0016323cellular_componentbasolateral plasma membrane
D0019722biological_processcalcium-mediated signaling
D0021510biological_processspinal cord development
D0021915biological_processneural tube development
D0022843molecular_functionvoltage-gated monoatomic cation channel activity
D0030027cellular_componentlamellipodium
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0031514cellular_componentmotile cilium
D0031587biological_processpositive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
D0031982cellular_componentvesicle
D0034614biological_processcellular response to reactive oxygen species
D0034702cellular_componentmonoatomic ion channel complex
D0034703cellular_componentcation channel complex
D0035502biological_processmetanephric part of ureteric bud development
D0035725biological_processsodium ion transmembrane transport
D0035904biological_processaorta development
D0036064cellular_componentciliary basal body
D0042127biological_processregulation of cell population proliferation
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042805molecular_functionactinin binding
D0043226cellular_componentorganelle
D0043398molecular_functionHLH domain binding
D0044325molecular_functiontransmembrane transporter binding
D0044782biological_processcilium organization
D0045180cellular_componentbasal cortex
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046872molecular_functionmetal ion binding
D0048763molecular_functioncalcium-induced calcium release activity
D0050982biological_processdetection of mechanical stimulus
D0051117molecular_functionATPase binding
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051219molecular_functionphosphoprotein binding
D0051262biological_processprotein tetramerization
D0051289biological_processprotein homotetramerization
D0051290biological_processprotein heterotetramerization
D0051298biological_processcentrosome duplication
D0051371molecular_functionmuscle alpha-actinin binding
D0051393molecular_functionalpha-actinin binding
D0051649biological_processestablishment of localization in cell
D0051726biological_processregulation of cell cycle
D0060170cellular_componentciliary membrane
D0060674biological_processplacenta blood vessel development
D0061333biological_processrenal tubule morphogenesis
D0061441biological_processrenal artery morphogenesis
D0070062cellular_componentextracellular exosome
D0070588biological_processcalcium ion transmembrane transport
D0071277biological_processcellular response to calcium ion
D0071320biological_processcellular response to cAMP
D0071464biological_processcellular response to hydrostatic pressure
D0071470biological_processcellular response to osmotic stress
D0071498biological_processcellular response to fluid shear stress
D0071805biological_processpotassium ion transmembrane transport
D0071910biological_processdetermination of liver left/right asymmetry
D0072075biological_processmetanephric mesenchyme development
D0072164biological_processmesonephric tubule development
D0072177biological_processmesonephric duct development
D0072208biological_processmetanephric smooth muscle tissue development
D0072214biological_processmetanephric cortex development
D0072218biological_processmetanephric ascending thin limb development
D0072219biological_processmetanephric cortical collecting duct development
D0072235biological_processmetanephric distal tubule development
D0072284biological_processmetanephric S-shaped body morphogenesis
D0072686cellular_componentmitotic spindle
D0090279biological_processregulation of calcium ion import
D0097730cellular_componentnon-motile cilium
D0098553cellular_componentlumenal side of endoplasmic reticulum membrane
D0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
D0098662biological_processinorganic cation transmembrane transport
D0140416molecular_functiontranscription regulator inhibitor activity
D0140494cellular_componentmigrasome
D2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2192
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
AMET1-SER219
CGLU490-SER505
CPHE574-LEU597
CPHE676-VAL968
DMET1-SER219
DGLU490-SER505
DPHE574-LEU597
DPHE676-VAL968
AGLU490-SER505
APHE574-LEU597
APHE676-VAL968
BMET1-SER219
BGLU490-SER505
BPHE574-LEU597
BPHE676-VAL968
CMET1-SER219

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
AVAL220-MET241
BVAL220-MET241
CVAL220-MET241
DVAL220-MET241

site_idSWS_FT_FI3
Number of Residues1076
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
AMET242-THR468
CTYR527-ALA552
CGLY620-GLU631
CALA647-ARG654
DMET242-THR468
DTYR527-ALA552
DGLY620-GLU631
DALA647-ARG654
ATYR527-ALA552
AGLY620-GLU631
AALA647-ARG654
BMET242-THR468
BTYR527-ALA552
BGLY620-GLU631
BALA647-ARG654
CMET242-THR468

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
APHE469-VAL489
BPHE469-VAL489
CPHE469-VAL489
DPHE469-VAL489

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
APHE506-ILE526
BPHE506-ILE526
CPHE506-ILE526
DPHE506-ILE526

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
ATYR553-LEU573
BTYR553-LEU573
CTYR553-LEU573
DTYR553-LEU573

site_idSWS_FT_FI7
Number of Residues84
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
APHE598-PHE619
BPHE598-PHE619
CPHE598-PHE619
DPHE598-PHE619

site_idSWS_FT_FI8
Number of Residues56
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
ACYS632-PHE646
BCYS632-PHE646
CCYS632-PHE646
DCYS632-PHE646

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=S6 => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
AVAL655-MET675
BVAL655-MET675
CVAL655-MET675
DVAL655-MET675

site_idSWS_FT_FI10
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:24990821, ECO:0007744|PDB:2Y4Q
ChainResidueDetails
AASP763
BGLU774
CASP763
CASP765
CASP767
CGLU769
CGLU774
DASP763
DASP765
DASP767
DGLU769
AASP765
DGLU774
AASP767
AGLU769
AGLU774
BASP763
BASP765
BASP767
BGLU769

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16551655
ChainResidueDetails
ASER76
BSER76
CSER76
DSER76

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:16551655
ChainResidueDetails
ASER80
BSER80
CSER80
DSER80

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:O35245
ChainResidueDetails
AARG137
BARG137
CARG137
DARG137

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20881056, ECO:0000305|PubMed:16551655
ChainResidueDetails
ASER801
BSER801
CSER801
DSER801

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35245
ChainResidueDetails
ASER808
BSER808
CSER808
DSER808

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:15692563, ECO:0000305|PubMed:16551655, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER812
BSER812
CSER812
DSER812

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:26269590
ChainResidueDetails
ASER829
BSER829
CSER829
DSER829

site_idSWS_FT_FI18
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28092368
ChainResidueDetails
AASN299
AASN305
BASN299
BASN305
CASN299
CASN305
DASN299
DASN305

site_idSWS_FT_FI19
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
AASN328
BASN328
CASN328
DASN328

site_idSWS_FT_FI20
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27768895, ECO:0000269|PubMed:27991905, ECO:0000269|PubMed:28092368
ChainResidueDetails
AASN362
AASN375
BASN362
BASN375
CASN362
CASN375
DASN362
DASN375

224004

PDB entries from 2024-08-21

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