5MIW
X-ray structure uridine phosphorylase from Vibrio cholerae in complex with uracil at 1.28 A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 301 |
| Chain | Residue |
| A | GLY25 |
| A | ASP26 |
| A | ARG29 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 302 |
| Chain | Residue |
| A | GLU48 |
| A | ILE68 |
| A | SER72 |
| B | GLU48 |
| B | ILE68 |
| B | SER72 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 303 |
| Chain | Residue |
| A | PHE133 |
| A | THR137 |
| A | HOH703 |
| F | PHE133 |
| F | THR137 |
| F | HOH683 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue URA A 304 |
| Chain | Residue |
| A | THR94 |
| A | GLY95 |
| A | PHE161 |
| A | GLN165 |
| A | ARG167 |
| A | PHE194 |
| A | GLU195 |
| A | MET196 |
| A | GOL306 |
| A | HOH524 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | ARG177 |
| A | HOH412 |
| A | HOH413 |
| A | HOH429 |
| C | ARG177 |
| C | HOH472 |
| E | ARG177 |
| E | HOH524 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | ARG90 |
| A | THR93 |
| A | PHE161 |
| A | GLU195 |
| A | MET196 |
| A | GLU197 |
| A | URA304 |
| A | HOH448 |
| A | HOH522 |
| A | HOH580 |
| B | HIS7 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 301 |
| Chain | Residue |
| B | GLY25 |
| B | ASP26 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| A | ASP169 |
| A | THR170 |
| B | LYS3 |
| B | GLN82 |
| B | HOH480 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue URA B 303 |
| Chain | Residue |
| B | THR93 |
| B | THR94 |
| B | GLY95 |
| B | PHE161 |
| B | GLN165 |
| B | ARG167 |
| B | PHE194 |
| B | GLU195 |
| B | MET196 |
| B | ILE220 |
| B | GOL306 |
| B | HOH522 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| B | ARG177 |
| B | HOH424 |
| D | ARG177 |
| F | ARG177 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| B | LEU115 |
| B | ARG178 |
| B | GLU185 |
| B | HOH409 |
| B | HOH434 |
| B | HOH610 |
| B | HOH615 |
| C | PRO124 |
| C | GLU126 |
| D | ARG177 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 306 |
| Chain | Residue |
| A | HIS7 |
| B | THR93 |
| B | PHE161 |
| B | GLU197 |
| B | URA303 |
| B | HOH412 |
| B | HOH414 |
| B | HOH440 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 307 |
| Chain | Residue |
| B | PHE133 |
| B | THR137 |
| B | HOH668 |
| C | PHE133 |
| C | THR137 |
| C | HOH658 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 301 |
| Chain | Residue |
| C | GLY25 |
| C | ASP26 |
| C | ARG29 |
| C | HOH446 |
| C | HOH597 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 302 |
| Chain | Residue |
| B | MET152 |
| B | HOH534 |
| C | PHE133 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 303 |
| Chain | Residue |
| C | GLN82 |
| C | HOH444 |
| C | HOH459 |
| D | THR170 |
| D | PHE171 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue URA C 304 |
| Chain | Residue |
| C | THR93 |
| C | THR94 |
| C | GLY95 |
| C | PHE161 |
| C | GLN165 |
| C | ARG167 |
| C | GLU195 |
| C | MET196 |
| C | GOL305 |
| C | HOH494 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue GOL C 305 |
| Chain | Residue |
| C | ILE68 |
| C | THR93 |
| C | GLU195 |
| C | MET196 |
| C | GLU197 |
| C | URA304 |
| C | HOH407 |
| C | HOH426 |
| C | HOH439 |
| D | HIS7 |
| site_id | AE1 |
| Number of Residues | 11 |
| Details | binding site for residue GOL C 306 |
| Chain | Residue |
| A | ARG177 |
| B | GLU126 |
| C | LEU115 |
| C | ARG178 |
| C | PHE179 |
| C | SER182 |
| C | GLU185 |
| C | TRP186 |
| C | HOH406 |
| C | HOH415 |
| C | HOH561 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 307 |
| Chain | Residue |
| C | GLU48 |
| C | ILE68 |
| C | SER72 |
| D | GLU48 |
| D | ILE68 |
| D | SER72 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 301 |
| Chain | Residue |
| D | PHE133 |
| D | HOH501 |
| D | HOH575 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 302 |
| Chain | Residue |
| C | HOH632 |
| D | GLY25 |
| D | ASP26 |
| D | HOH471 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 303 |
| Chain | Residue |
| D | PHE133 |
| D | THR137 |
| D | HOH649 |
| E | PHE133 |
| E | THR137 |
| E | HOH677 |
| site_id | AE6 |
| Number of Residues | 10 |
| Details | binding site for residue URA D 304 |
| Chain | Residue |
| D | THR94 |
| D | GLY95 |
| D | PHE161 |
| D | GLN165 |
| D | ARG167 |
| D | GLU195 |
| D | MET196 |
| D | GOL306 |
| D | HOH406 |
| D | HOH479 |
| site_id | AE7 |
| Number of Residues | 10 |
| Details | binding site for residue GOL D 305 |
| Chain | Residue |
| D | LEU115 |
| D | ARG178 |
| D | PHE179 |
| D | GLU185 |
| D | HOH411 |
| D | HOH434 |
| D | HOH521 |
| E | PRO124 |
| E | GLU126 |
| F | ARG177 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 306 |
| Chain | Residue |
| C | HIS7 |
| D | ILE68 |
| D | THR93 |
| D | PHE161 |
| D | GLU197 |
| D | URA304 |
| D | HOH418 |
| D | HOH441 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue CL E 301 |
| Chain | Residue |
| E | GLY25 |
| E | ASP26 |
| E | ARG29 |
| F | HOH614 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue NA E 302 |
| Chain | Residue |
| E | GLU48 |
| E | ILE68 |
| E | SER72 |
| F | GLU48 |
| F | ILE68 |
| F | SER72 |
| site_id | AF2 |
| Number of Residues | 11 |
| Details | binding site for residue URA E 303 |
| Chain | Residue |
| E | THR93 |
| E | THR94 |
| E | GLY95 |
| E | PHE161 |
| E | GLN165 |
| E | ARG167 |
| E | GLU195 |
| E | MET196 |
| E | ILE220 |
| E | GOL304 |
| E | HOH493 |
| site_id | AF3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL E 304 |
| Chain | Residue |
| E | THR93 |
| E | PHE161 |
| E | MET196 |
| E | GLU197 |
| E | URA303 |
| E | HOH409 |
| E | HOH435 |
| E | HOH449 |
| F | HIS7 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue CL F 301 |
| Chain | Residue |
| F | GLY25 |
| F | ASP26 |
| F | ARG29 |
| F | HOH409 |
| F | HOH645 |
| site_id | AF5 |
| Number of Residues | 11 |
| Details | binding site for residue URA F 302 |
| Chain | Residue |
| F | THR93 |
| F | THR94 |
| F | GLY95 |
| F | PHE161 |
| F | GLN165 |
| F | ARG167 |
| F | GLU195 |
| F | MET196 |
| F | ILE220 |
| F | GOL303 |
| F | HOH504 |
| site_id | AF6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL F 303 |
| Chain | Residue |
| E | HIS7 |
| E | HOH422 |
| F | ILE68 |
| F | THR93 |
| F | PHE161 |
| F | MET196 |
| F | GLU197 |
| F | URA302 |
| F | HOH427 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL F 304 |
| Chain | Residue |
| A | PRO124 |
| A | GLU126 |
| B | ARG177 |
| F | ARG178 |
| F | GLU185 |
| F | HOH413 |
| F | HOH421 |
| F | HOH565 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER65-LEU80 |
