5MIO
KIF2C-DARPIN FUSION PROTEIN BOUND TO TUBULIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0005881 | cellular_component | cytoplasmic microtubule |
| A | 0005929 | cellular_component | cilium |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030182 | biological_process | neuron differentiation |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007010 | biological_process | cytoskeleton organization |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003777 | molecular_function | microtubule motor activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0007018 | biological_process | microtubule-based movement |
| C | 0008017 | molecular_function | microtubule binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GTP A 501 |
| Chain | Residue |
| A | GLY10 |
| A | GLY143 |
| A | GLY144 |
| A | THR145 |
| A | GLY146 |
| A | VAL177 |
| A | SER178 |
| A | THR179 |
| A | GLU183 |
| A | ASN206 |
| A | TYR224 |
| A | GLN11 |
| A | ASN228 |
| A | ILE231 |
| A | MG502 |
| B | LYS254 |
| A | ALA12 |
| A | GLN15 |
| A | ASP98 |
| A | ALA99 |
| A | ALA100 |
| A | ASN101 |
| A | SER140 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | GTP501 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue GDP B 501 |
| Chain | Residue |
| B | GLY10 |
| B | GLN11 |
| B | CYS12 |
| B | GLN15 |
| B | SER140 |
| B | GLY143 |
| B | GLY144 |
| B | THR145 |
| B | GLY146 |
| B | PRO173 |
| B | VAL177 |
| B | ASP179 |
| B | GLU183 |
| B | ASN206 |
| B | TYR224 |
| B | ASN228 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue LOC B 502 |
| Chain | Residue |
| A | THR179 |
| A | ALA180 |
| A | VAL181 |
| B | CYS241 |
| B | LEU248 |
| B | ALA250 |
| B | ASP251 |
| B | LYS254 |
| B | LEU255 |
| B | ASN258 |
| B | THR314 |
| B | VAL315 |
| B | ALA316 |
| B | ILE318 |
| B | ASN350 |
| B | LYS352 |
| B | ILE378 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 801 |
| Chain | Residue |
| C | THR355 |
| C | ARG456 |
| C | SER468 |
| C | ASP492 |
| C | ANP802 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue ANP C 802 |
| Chain | Residue |
| C | PRO267 |
| C | THR350 |
| C | GLY351 |
| C | SER352 |
| C | GLY353 |
| C | LYS354 |
| C | THR355 |
| C | HIS356 |
| C | ASP361 |
| C | ASN464 |
| C | SER467 |
| C | SER468 |
| C | ALA494 |
| C | GLY495 |
| C | MG801 |
Functional Information from PROSITE/UniProt
| site_id | PS00227 |
| Number of Residues | 7 |
| Details | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
| Chain | Residue | Details |
| A | GLY142-GLY148 | |
| B | GLY142-GLY148 |
| site_id | PS00228 |
| Number of Residues | 4 |
| Details | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI |
| Chain | Residue | Details |
| B | MET1-ILE4 |
| site_id | PS00411 |
| Number of Residues | 12 |
| Details | KINESIN_MOTOR_1 Kinesin motor domain signature. GKFsLVDLAGNE |
| Chain | Residue | Details |
| C | GLY486-GLU497 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
