5MIM
Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n
GO（遺伝子オントロジー）由来の情報
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 6 |
| 詳細 | binding site for residue CA A 601 |
| 鎖名 | 残基 |
| A | ASP174 |
| A | ASP179 |
| A | ASP181 |
| A | HOH736 |
| A | HOH762 |
| A | HOH1071 |
| site_id | AC2 |
| 残基数 | 6 |
| 詳細 | binding site for residue CA A 602 |
| 鎖名 | 残基 |
| A | ASN208 |
| A | VAL210 |
| A | GLY212 |
| A | ASP115 |
| A | ASP162 |
| A | VAL205 |
| site_id | AC3 |
| 残基数 | 6 |
| 詳細 | binding site for residue CA A 603 |
| 鎖名 | 残基 |
| A | ASP258 |
| A | ASP301 |
| A | GLU331 |
| A | HOH825 |
| A | HOH932 |
| A | HOH1023 |
| site_id | AC4 |
| 残基数 | 5 |
| 詳細 | binding site for residue NA A 604 |
| 鎖名 | 残基 |
| A | THR309 |
| A | SER311 |
| A | THR314 |
| A | SER316 |
| A | HOH867 |
| site_id | AC5 |
| 残基数 | 6 |
| 詳細 | binding site for residue NA A 605 |
| 鎖名 | 残基 |
| A | SER279 |
| A | GLY284 |
| A | HOH748 |
| A | HOH757 |
| A | HOH1104 |
| A | HOH1121 |
| site_id | AC6 |
| 残基数 | 4 |
| 詳細 | binding site for residue NA A 606 |
| 鎖名 | 残基 |
| A | SER544 |
| A | SER544 |
| A | HOH804 |
| A | HOH804 |
| site_id | AC7 |
| 残基数 | 6 |
| 詳細 | binding site for residue NA A 607 |
| 鎖名 | 残基 |
| A | GLU546 |
| A | GLU546 |
| A | HOH1074 |
| A | HOH1074 |
| A | HOH1089 |
| A | HOH1089 |
| site_id | AC8 |
| 残基数 | 4 |
| 詳細 | binding site for residue CL A 608 |
| 鎖名 | 残基 |
| A | ARG276 |
| A | TYR313 |
| A | LYS449 |
| A | TYR571 |
| site_id | AC9 |
| 残基数 | 7 |
| 詳細 | binding site for residue 1N A 609 |
| 鎖名 | 残基 |
| A | ARG185 |
| A | ASP191 |
| A | ASN192 |
| A | LEU227 |
| A | ASP228 |
| A | GLY229 |
| A | GLU230 |
| site_id | AD1 |
| 残基数 | 13 |
| 詳細 | binding site for residue 1N A 610 |
| 鎖名 | 残基 |
| A | ASP153 |
| A | HIS194 |
| A | CYS198 |
| A | LEU227 |
| A | VAL231 |
| A | GLU236 |
| A | SER253 |
| A | GLY255 |
| A | ASP264 |
| A | TYR308 |
| A | SER368 |
| A | HOH770 |
| A | HOH1025 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS00136 |
| 残基数 | 12 |
| 詳細 | SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VSILDDGIeknH |
| 鎖名 | 残基 | 詳細 |
| A | VAL149-HIS160 |
| site_id | PS00137 |
| 残基数 | 11 |
| 詳細 | SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTrCAGeVAA |
| 鎖名 | 残基 | 詳細 |
| A | HIS194-ALA204 |
| site_id | PS00138 |
| 残基数 | 11 |
| 詳細 | SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSaSaPlAAG |
| 鎖名 | 残基 | 詳細 |
| A | GLY366-GLY376 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 3 |
| 詳細 | ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 |
| 鎖名 | 残基 | 詳細 |
| A | ASP153 | |
| A | HIS194 | |
| A | SER368 |
| site_id | SWS_FT_FI2 |
| 残基数 | 12 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD |
| 鎖名 | 残基 | 詳細 |
| A | ASP115 | |
| A | ASP258 | |
| A | ASP301 | |
| A | GLU331 | |
| A | ASP162 | |
| A | ASP174 | |
| A | ASP179 | |
| A | ASP181 | |
| A | VAL205 | |
| A | ASN208 | |
| A | VAL210 | |
| A | GLY212 |
| site_id | SWS_FT_FI3 |
| 残基数 | 9 |
| 詳細 | BINDING: BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD |
| 鎖名 | 残基 | 詳細 |
| A | ASP154 | |
| A | ASP191 | |
| A | GLU236 | |
| A | SER253 | |
| A | ASP264 | |
| A | ALA292 | |
| A | ASP306 | |
| A | TYR308 | |
| A | SER368 |
| site_id | SWS_FT_FI4 |
| 残基数 | 3 |
| 詳細 | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| 鎖名 | 残基 | 詳細 |
| A | ASN387 | |
| A | ASN440 | |
| A | ASN553 |
