5MGZ
Streptomyces Spheroides NovO (8-demethylnovbiocic acid methyltransferase) with SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0032259 | biological_process | methylation |
| A | 0043642 | biological_process | novobiocin biosynthetic process |
| A | 0102526 | molecular_function | 8-demethylnovobiocic acid C8-methyltransferase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0032259 | biological_process | methylation |
| B | 0043642 | biological_process | novobiocin biosynthetic process |
| B | 0102526 | molecular_function | 8-demethylnovobiocic acid C8-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | GLU4 |
| A | LEU71 |
| A | SER72 |
| A | MET75 |
| A | GLY95 |
| A | ASP96 |
| A | ALA97 |
| A | GLN98 |
| A | ARG116 |
| A | ASN117 |
| A | ALA118 |
| A | ALA5 |
| A | LEU122 |
| A | ACT303 |
| A | HOH417 |
| A | HOH449 |
| A | HOH457 |
| A | ILE6 |
| A | PHE14 |
| A | TYR25 |
| A | CYS47 |
| A | CYS48 |
| A | GLY49 |
| A | ASP70 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | ARG116 |
| A | ASN117 |
| A | TYR216 |
| A | HOH421 |
| A | HOH484 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 303 |
| Chain | Residue |
| A | ASN117 |
| A | HIS120 |
| A | ARG121 |
| A | ALA181 |
| A | SAH301 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for residue SAH B 301 |
| Chain | Residue |
| B | GLU4 |
| B | ALA5 |
| B | ILE6 |
| B | PHE14 |
| B | TYR25 |
| B | CYS47 |
| B | CYS48 |
| B | GLY49 |
| B | ASP70 |
| B | LEU71 |
| B | SER72 |
| B | MET75 |
| B | GLY95 |
| B | ASP96 |
| B | ALA97 |
| B | GLN98 |
| B | ARG116 |
| B | ASN117 |
| B | ALA118 |
| B | LEU122 |
| B | HOH422 |
| B | HOH438 |
| B | HOH487 |
