5MEY
Crystal structure of Smad4-MH1 bound to the GGCGC site.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 201 |
| Chain | Residue |
| A | CYS71 |
| A | CYS115 |
| A | CYS127 |
| A | HIS132 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 202 |
| Chain | Residue |
| A | ARG27 |
| A | GLY29 |
| A | GLY30 |
| A | GLU31 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 203 |
| Chain | Residue |
| A | GLN75 |
| A | ILE74 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 204 |
| Chain | Residue |
| A | PHE119 |
| A | ASP120 |
| A | TYR133 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 205 |
| Chain | Residue |
| A | GLU31 |
| A | SER32 |
| A | ARG87 |
| A | GLN116 |
| A | TYR117 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 206 |
| Chain | Residue |
| A | CYS71 |
| A | TYR117 |
| A | SER125 |
| A | HOH312 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 207 |
| Chain | Residue |
| A | ARG27 |
| A | LYS122 |
| A | HOH348 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 101 |
| Chain | Residue |
| D | DG9 |
| D | DC10 |
| D | DG11 |
| D | HOH217 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CA D 102 |
| Chain | Residue |
| D | DG6 |
| D | DG7 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CA D 103 |
| Chain | Residue |
| D | DG5 |
| D | DC14 |
| D | DG15 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CA D 104 |
| Chain | Residue |
| D | DG15 |
| D | DC16 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CA D 105 |
| Chain | Residue |
| D | DG3 |
| D | DC16 |
| D | DA17 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue CA D 106 |
| Chain | Residue |
| D | DC16 |
| D | DA17 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Region: {"description":"Required for interaction with TSC22D1","evidences":[{"source":"PubMed","id":"15881652","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
