5MER
Human Leukocyte Antigen A02 presenting ILAKFLHEL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001913 | biological_process | T cell mediated cytotoxicity |
| B | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
| B | 0002237 | biological_process | response to molecule of bacterial origin |
| B | 0002376 | biological_process | immune system process |
| B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| B | 0002481 | biological_process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
| B | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0002726 | biological_process | positive regulation of T cell cytokine production |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006955 | biological_process | immune response |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0007611 | biological_process | learning or memory |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0010038 | biological_process | response to metal ion |
| B | 0010977 | biological_process | negative regulation of neuron projection development |
| B | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031905 | cellular_component | early endosome lumen |
| B | 0033077 | biological_process | T cell differentiation in thymus |
| B | 0033572 | biological_process | transferrin transport |
| B | 0034756 | biological_process | regulation of iron ion transport |
| B | 0034757 | biological_process | negative regulation of iron ion transport |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042026 | biological_process | protein refolding |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042824 | cellular_component | MHC class I peptide loading complex |
| B | 0045646 | biological_process | regulation of erythrocyte differentiation |
| B | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| B | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| B | 0050768 | biological_process | negative regulation of neurogenesis |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0071283 | biological_process | cellular response to iron(III) ion |
| B | 0071316 | biological_process | cellular response to nicotine |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1990000 | biological_process | amyloid fibril formation |
| B | 1990712 | cellular_component | HFE-transferrin receptor complex |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
| B | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
| E | 0000139 | cellular_component | Golgi membrane |
| E | 0001913 | biological_process | T cell mediated cytotoxicity |
| E | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
| E | 0002237 | biological_process | response to molecule of bacterial origin |
| E | 0002376 | biological_process | immune system process |
| E | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| E | 0002481 | biological_process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
| E | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| E | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| E | 0002726 | biological_process | positive regulation of T cell cytokine production |
| E | 0005198 | molecular_function | structural molecule activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0005765 | cellular_component | lysosomal membrane |
| E | 0005783 | cellular_component | endoplasmic reticulum |
| E | 0005788 | cellular_component | endoplasmic reticulum lumen |
| E | 0005794 | cellular_component | Golgi apparatus |
| E | 0005829 | cellular_component | cytosol |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0005925 | cellular_component | focal adhesion |
| E | 0006826 | biological_process | iron ion transport |
| E | 0006879 | biological_process | intracellular iron ion homeostasis |
| E | 0006955 | biological_process | immune response |
| E | 0007608 | biological_process | sensory perception of smell |
| E | 0007611 | biological_process | learning or memory |
| E | 0009897 | cellular_component | external side of plasma membrane |
| E | 0009986 | cellular_component | cell surface |
| E | 0010038 | biological_process | response to metal ion |
| E | 0010977 | biological_process | negative regulation of neuron projection development |
| E | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| E | 0016020 | cellular_component | membrane |
| E | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| E | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| E | 0023026 | molecular_function | MHC class II protein complex binding |
| E | 0030670 | cellular_component | phagocytic vesicle membrane |
| E | 0031901 | cellular_component | early endosome membrane |
| E | 0031902 | cellular_component | late endosome membrane |
| E | 0031905 | cellular_component | early endosome lumen |
| E | 0033077 | biological_process | T cell differentiation in thymus |
| E | 0033572 | biological_process | transferrin transport |
| E | 0034756 | biological_process | regulation of iron ion transport |
| E | 0034757 | biological_process | negative regulation of iron ion transport |
| E | 0035580 | cellular_component | specific granule lumen |
| E | 0042026 | biological_process | protein refolding |
| E | 0042605 | molecular_function | peptide antigen binding |
| E | 0042612 | cellular_component | MHC class I protein complex |
| E | 0042613 | cellular_component | MHC class II protein complex |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0042824 | cellular_component | MHC class I peptide loading complex |
| E | 0045646 | biological_process | regulation of erythrocyte differentiation |
| E | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| E | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| E | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| E | 0050768 | biological_process | negative regulation of neurogenesis |
| E | 0050778 | biological_process | positive regulation of immune response |
| E | 0050870 | biological_process | positive regulation of T cell activation |
| E | 0051289 | biological_process | protein homotetramerization |
| E | 0055038 | cellular_component | recycling endosome membrane |
| E | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0071281 | biological_process | cellular response to iron ion |
| E | 0071283 | biological_process | cellular response to iron(III) ion |
| E | 0071316 | biological_process | cellular response to nicotine |
| E | 1904724 | cellular_component | tertiary granule lumen |
| E | 1990000 | biological_process | amyloid fibril formation |
| E | 1990712 | cellular_component | HFE-transferrin receptor complex |
| E | 2000774 | biological_process | positive regulation of cellular senescence |
| E | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | ARG6 |
| A | PHE8 |
| A | ASP29 |
| A | ASP30 |
| A | HOH414 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | LYS121 |
| A | ASP122 |
| A | HOH404 |
| B | TRP60 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 303 |
| Chain | Residue |
| A | ARG14 |
| A | GLY16 |
| A | GLY18 |
| A | HOH476 |
| A | HOH530 |
| A | HOH531 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue MES A 304 |
| Chain | Residue |
| A | MET138 |
| A | GLN141 |
| A | THR142 |
| A | HIS145 |
| A | HOH514 |
| E | ARG45 |
| E | ARG81 |
| E | HOH210 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 101 |
| Chain | Residue |
| A | HIS188 |
| A | THR190 |
| A | TRP204 |
| B | ARG97 |
| B | ASP98 |
| B | EDO106 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 102 |
| Chain | Residue |
| B | ASP96 |
| B | HOH203 |
| E | GLU74 |
| E | LYS75 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 103 |
| Chain | Residue |
| B | TRP95 |
| B | ASP96 |
| B | ARG97 |
| B | HOH259 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 104 |
| Chain | Residue |
| B | GLN8 |
| B | VAL9 |
| B | LYS94 |
| B | ASP96 |
| B | HOH206 |
| B | HOH235 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 105 |
| Chain | Residue |
| A | GLN115 |
| B | SER57 |
| B | LYS58 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue EDO B 106 |
| Chain | Residue |
| A | TRP204 |
| A | LEU206 |
| A | ARG234 |
| A | GLN242 |
| B | TYR10 |
| B | SER11 |
| B | HIS13 |
| B | PRO14 |
| B | EDO101 |
| B | HOH221 |
| B | HOH226 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 107 |
| Chain | Residue |
| B | LYS6 |
| B | ILE7 |
| B | HOH205 |
| B | HOH248 |
| B | HOH261 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue MES B 108 |
| Chain | Residue |
| A | GLU232 |
| A | THR233 |
| A | LYS243 |
| A | HOH445 |
| A | HOH480 |
| B | SER57 |
| B | LYS58 |
| B | ASP59 |
| B | SO4109 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 109 |
| Chain | Residue |
| B | SER57 |
| B | LYS58 |
| B | MES108 |
| B | HOH239 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 110 |
| Chain | Residue |
| B | ASP34 |
| B | ILE35 |
| B | GLU36 |
| B | ASN83 |
| B | HIS84 |
| B | VAL85 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 101 |
| Chain | Residue |
| A | GLN155 |
| A | LEU156 |
| A | TYR159 |
| C | LYS4 |
| C | PHE5 |
| C | EDO102 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 102 |
| Chain | Residue |
| A | ARG97 |
| A | TRP147 |
| A | VAL152 |
| C | LEU6 |
| C | HIS7 |
| C | GOL101 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 103 |
| Chain | Residue |
| A | TRP167 |
| C | LYS4 |
| C | HOH201 |
| D | ARG131 |
| D | ARG157 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| D | GLU232 |
| D | HOH418 |
| D | HOH481 |
| D | HOH503 |
| D | HOH514 |
| E | GLN8 |
| D | VAL231 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO D 302 |
| Chain | Residue |
| D | ASP122 |
| D | TYR123 |
| D | ILE124 |
| D | ALA125 |
| D | THR134 |
| D | ALA136 |
| D | HOH404 |
| D | HOH457 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 303 |
| Chain | Residue |
| D | HIS188 |
| D | THR190 |
| D | TRP204 |
| E | ASP98 |
| E | EDO102 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 304 |
| Chain | Residue |
| A | ARG157 |
| D | THR163 |
| D | TRP167 |
| D | HOH403 |
| F | LYS4 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 305 |
| Chain | Residue |
| D | TYR85 |
| D | TYR118 |
| D | LYS121 |
| D | ASP122 |
| D | TYR123 |
| D | ASP137 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 306 |
| Chain | Residue |
| D | ARG14 |
| D | GLY16 |
| D | GLY18 |
| D | HOH465 |
| D | HOH549 |
| D | HOH550 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue MES D 307 |
| Chain | Residue |
| B | GLY43 |
| B | GLU44 |
| B | ARG45 |
| B | ARG81 |
| D | THR142 |
| D | HIS145 |
| D | HOH546 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 308 |
| Chain | Residue |
| A | ARG35 |
| A | ALA40 |
| A | ALA41 |
| D | SER88 |
| D | HOH415 |
| D | HOH419 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 309 |
| Chain | Residue |
| D | GLU232 |
| D | THR233 |
| D | LYS243 |
| E | MES107 |
| E | SO4108 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 310 |
| Chain | Residue |
| B | ASN17 |
| B | GLU74 |
| D | HIS191 |
| D | HIS192 |
| D | ALA193 |
| D | HOH435 |
| D | HOH459 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 311 |
| Chain | Residue |
| A | SER88 |
| D | ARG35 |
| D | ALA40 |
| D | ALA41 |
| D | HOH420 |
| D | HOH445 |
| D | HOH483 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 312 |
| Chain | Residue |
| D | SER2 |
| D | HIS3 |
| D | ARG6 |
| D | ASP102 |
| D | HOH430 |
| D | HOH450 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 313 |
| Chain | Residue |
| D | ARG6 |
| D | PHE8 |
| D | TYR27 |
| D | ASP29 |
| D | ASP30 |
| D | HOH437 |
| E | MES107 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 101 |
| Chain | Residue |
| A | HIS191 |
| A | HIS192 |
| A | ALA193 |
| E | ASN17 |
| E | HOH221 |
| site_id | AF5 |
| Number of Residues | 11 |
| Details | binding site for residue EDO E 102 |
| Chain | Residue |
| D | TRP204 |
| D | LEU206 |
| D | ARG234 |
| D | GLN242 |
| D | EDO303 |
| E | TYR10 |
| E | SER11 |
| E | HIS13 |
| E | PRO14 |
| E | HOH232 |
| E | HOH240 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 103 |
| Chain | Residue |
| E | GLU74 |
| E | TRP95 |
| E | ASP96 |
| E | ARG97 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 104 |
| Chain | Residue |
| E | GLN8 |
| E | VAL9 |
| E | LYS94 |
| E | ASP96 |
| E | HOH220 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 105 |
| Chain | Residue |
| E | LEU40 |
| E | ASN42 |
| E | GLY43 |
| E | GLU77 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 106 |
| Chain | Residue |
| D | GLN115 |
| E | SER57 |
| E | LYS58 |
| site_id | AG1 |
| Number of Residues | 8 |
| Details | binding site for residue MES E 107 |
| Chain | Residue |
| D | THR233 |
| D | SO4309 |
| D | SO4313 |
| E | TYR26 |
| E | SER57 |
| E | LYS58 |
| E | SO4108 |
| E | HOH226 |
| site_id | AG2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 E 108 |
| Chain | Residue |
| D | SO4309 |
| D | HOH467 |
| E | SER57 |
| E | LYS58 |
| E | ASP59 |
| E | MES107 |
| E | HOH215 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO F 101 |
| Chain | Residue |
| D | ARG97 |
| D | TRP147 |
| D | VAL152 |
| F | LEU6 |
| F | HIS7 |
| F | HOH206 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH |
| Chain | Residue | Details |
| A | TYR257-HIS263 | |
| B | TYR78-HIS84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 172 |
| Details | Domain: {"description":"Ig-like C1-type","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 178 |
| Details | Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 182 |
| Details | Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 182 |
| Details | Region: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21943705","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21543847","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 176 |
| Details | Domain: {"description":"Ig-like C1-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
