Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MER

Human Leukocyte Antigen A02 presenting ILAKFLHEL

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0000139	cellular_component	Golgi membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002376	biological_process	immune system process
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010977	biological_process	negative regulation of neuron projection development
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0016020	cellular_component	membrane
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0031905	cellular_component	early endosome lumen
E	0032092	biological_process	positive regulation of protein binding
E	0033077	biological_process	T cell differentiation in thymus
E	0034756	biological_process	regulation of iron ion transport
E	0035580	cellular_component	specific granule lumen
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0055038	cellular_component	recycling endosome membrane
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0070062	cellular_component	extracellular exosome
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1900121	biological_process	negative regulation of receptor binding
E	1900122	biological_process	positive regulation of receptor binding
E	1904434	biological_process	positive regulation of ferrous iron binding
E	1904437	biological_process	positive regulation of transferrin receptor binding
E	1904724	cellular_component	tertiary granule lumen
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 301

Chain	Residue
A	ARG6
A	PHE8
A	ASP29
A	ASP30
A	HOH414

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	LYS121
A	ASP122
A	HOH404
B	TRP60

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 303

Chain	Residue
A	ARG14
A	GLY16
A	GLY18
A	HOH476
A	HOH530
A	HOH531

site_id	AC4
Number of Residues	8
Details	binding site for residue MES A 304

Chain	Residue
A	MET138
A	GLN141
A	THR142
A	HIS145
A	HOH514
E	ARG45
E	ARG81
E	HOH210

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO B 101

Chain	Residue
A	HIS188
A	THR190
A	TRP204
B	ARG97
B	ASP98
B	EDO106

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO B 102

Chain	Residue
B	ASP96
B	HOH203
E	GLU74
E	LYS75

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 103

Chain	Residue
B	TRP95
B	ASP96
B	ARG97
B	HOH259

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO B 104

Chain	Residue
B	GLN8
B	VAL9
B	LYS94
B	ASP96
B	HOH206
B	HOH235

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO B 105

Chain	Residue
A	GLN115
B	SER57
B	LYS58

site_id	AD1
Number of Residues	11
Details	binding site for residue EDO B 106

Chain	Residue
A	TRP204
A	LEU206
A	ARG234
A	GLN242
B	TYR10
B	SER11
B	HIS13
B	PRO14
B	EDO101
B	HOH221
B	HOH226

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO B 107

Chain	Residue
B	LYS6
B	ILE7
B	HOH205
B	HOH248
B	HOH261

site_id	AD3
Number of Residues	9
Details	binding site for residue MES B 108

Chain	Residue
A	GLU232
A	THR233
A	LYS243
A	HOH445
A	HOH480
B	SER57
B	LYS58
B	ASP59
B	SO4109

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 B 109

Chain	Residue
B	SER57
B	LYS58
B	MES108
B	HOH239

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 B 110

Chain	Residue
B	ASP34
B	ILE35
B	GLU36
B	ASN83
B	HIS84
B	VAL85

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL C 101

Chain	Residue
A	GLN155
A	LEU156
A	TYR159
C	LYS4
C	PHE5
C	EDO102

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO C 102

Chain	Residue
A	ARG97
A	TRP147
A	VAL152
C	LEU6
C	HIS7
C	GOL101

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 C 103

Chain	Residue
A	TRP167
C	LYS4
C	HOH201
D	ARG131
D	ARG157

site_id	AD9
Number of Residues	7
Details	binding site for residue GOL D 301

Chain	Residue
D	GLU232
D	HOH418
D	HOH481
D	HOH503
D	HOH514
E	GLN8
D	VAL231

site_id	AE1
Number of Residues	8
Details	binding site for residue EDO D 302

Chain	Residue
D	ASP122
D	TYR123
D	ILE124
D	ALA125
D	THR134
D	ALA136
D	HOH404
D	HOH457

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO D 303

Chain	Residue
D	HIS188
D	THR190
D	TRP204
E	ASP98
E	EDO102

site_id	AE3
Number of Residues	5
Details	binding site for residue EDO D 304

Chain	Residue
A	ARG157
D	THR163
D	TRP167
D	HOH403
F	LYS4

site_id	AE4
Number of Residues	6
Details	binding site for residue EDO D 305

Chain	Residue
D	TYR85
D	TYR118
D	LYS121
D	ASP122
D	TYR123
D	ASP137

site_id	AE5
Number of Residues	6
Details	binding site for residue CA D 306

Chain	Residue
D	ARG14
D	GLY16
D	GLY18
D	HOH465
D	HOH549
D	HOH550

site_id	AE6
Number of Residues	7
Details	binding site for residue MES D 307

Chain	Residue
B	GLY43
B	GLU44
B	ARG45
B	ARG81
D	THR142
D	HIS145
D	HOH546

site_id	AE7
Number of Residues	6
Details	binding site for residue SO4 D 308

Chain	Residue
A	ARG35
A	ALA40
A	ALA41
D	SER88
D	HOH415
D	HOH419

site_id	AE8
Number of Residues	5
Details	binding site for residue SO4 D 309

Chain	Residue
D	GLU232
D	THR233
D	LYS243
E	MES107
E	SO4108

site_id	AE9
Number of Residues	7
Details	binding site for residue SO4 D 310

Chain	Residue
B	ASN17
B	GLU74
D	HIS191
D	HIS192
D	ALA193
D	HOH435
D	HOH459

site_id	AF1
Number of Residues	7
Details	binding site for residue SO4 D 311

Chain	Residue
A	SER88
D	ARG35
D	ALA40
D	ALA41
D	HOH420
D	HOH445
D	HOH483

site_id	AF2
Number of Residues	6
Details	binding site for residue SO4 D 312

Chain	Residue
D	SER2
D	HIS3
D	ARG6
D	ASP102
D	HOH430
D	HOH450

site_id	AF3
Number of Residues	7
Details	binding site for residue SO4 D 313

Chain	Residue
D	ARG6
D	PHE8
D	TYR27
D	ASP29
D	ASP30
D	HOH437
E	MES107

site_id	AF4
Number of Residues	5
Details	binding site for residue GOL E 101

Chain	Residue
A	HIS191
A	HIS192
A	ALA193
E	ASN17
E	HOH221

site_id	AF5
Number of Residues	11
Details	binding site for residue EDO E 102

Chain	Residue
D	TRP204
D	LEU206
D	ARG234
D	GLN242
D	EDO303
E	TYR10
E	SER11
E	HIS13
E	PRO14
E	HOH232
E	HOH240

site_id	AF6
Number of Residues	4
Details	binding site for residue EDO E 103

Chain	Residue
E	GLU74
E	TRP95
E	ASP96
E	ARG97

site_id	AF7
Number of Residues	5
Details	binding site for residue EDO E 104

Chain	Residue
E	GLN8
E	VAL9
E	LYS94
E	ASP96
E	HOH220

site_id	AF8
Number of Residues	4
Details	binding site for residue EDO E 105

Chain	Residue
E	LEU40
E	ASN42
E	GLY43
E	GLU77

site_id	AF9
Number of Residues	3
Details	binding site for residue EDO E 106

Chain	Residue
D	GLN115
E	SER57
E	LYS58

site_id	AG1
Number of Residues	8
Details	binding site for residue MES E 107

Chain	Residue
D	THR233
D	SO4309
D	SO4313
E	TYR26
E	SER57
E	LYS58
E	SO4108
E	HOH226

site_id	AG2
Number of Residues	7
Details	binding site for residue SO4 E 108

Chain	Residue
D	SO4309
D	HOH467
E	SER57
E	LYS58
E	ASP59
E	MES107
E	HOH215

site_id	AG3
Number of Residues	6
Details	binding site for residue EDO F 101

Chain	Residue
D	ARG97
D	TRP147
D	VAL152
F	LEU6
F	HIS7
F	HOH206

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN2
D	THR143
D	LYS146
D	TYR171
E	GLN2
A	TYR84
A	THR143
A	LYS146
A	TYR171
D	TYR7
D	THR73
D	TYR84

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE1
E	ILE1
D	TYR116
D	TYR159

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS19
E	LYS58
E	LYS91
E	LYS94
B	LYS41
B	LYS48
B	LYS58
B	LYS91
B	LYS94
E	LYS19
E	LYS41
E	LYS48

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN86
D	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)