5MCV
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006915 | biological_process | apoptotic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006915 | biological_process | apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | CYS176 |
| A | HIS179 |
| A | CYS238 |
| A | CYS242 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | PRO142 |
| A | PHE113 |
| A | LEU114 |
| A | SER116 |
| A | CYS124 |
| A | MET133 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | LYS132 |
| A | SER240 |
| A | PRO250 |
| A | GLU271 |
| A | VAL272 |
| A | ARG273 |
| A | GLU285 |
| A | HOH486 |
| A | HOH526 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | SER260 |
| A | HOH473 |
| B | GLN100 |
| B | SER269 |
| B | EDO306 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | ASN131 |
| A | LYS164 |
| A | LEU252 |
| A | GLU271 |
| A | HOH427 |
| A | HOH488 |
| A | HOH528 |
| B | EDO304 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | ARG110 |
| A | LEU111 |
| A | TRP146 |
| A | ACT307 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue ACT A 307 |
| Chain | Residue |
| A | LEU111 |
| A | TYR126 |
| A | EDO306 |
| A | HOH444 |
| A | HOH547 |
| A | HOH557 |
| A | HOH561 |
| B | SER261 |
| B | ASN263 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS176 |
| B | HIS179 |
| B | CYS238 |
| B | CYS242 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| B | PHE113 |
| B | LEU114 |
| B | SER116 |
| B | CYS124 |
| B | MET133 |
| B | PRO142 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | LYS132 |
| B | SER240 |
| B | PRO250 |
| B | GLU271 |
| B | VAL272 |
| B | ARG273 |
| B | GLU285 |
| B | HOH489 |
| B | HOH532 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 304 |
| Chain | Residue |
| A | GLN100 |
| A | SER269 |
| A | EDO305 |
| B | SER260 |
| B | HOH466 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 305 |
| Chain | Residue |
| B | ARG110 |
| B | LEU111 |
| B | GLY112 |
| B | TRP146 |
| B | ACT307 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 306 |
| Chain | Residue |
| A | EDO304 |
| B | ASN131 |
| B | LYS164 |
| B | LEU252 |
| B | GLU271 |
| B | HOH421 |
| B | HOH497 |
| B | HOH535 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue ACT B 307 |
| Chain | Residue |
| A | SER261 |
| A | ASN263 |
| B | LEU111 |
| B | TYR126 |
| B | EDO305 |
| B | HOH462 |
| B | HOH545 |
| B | HOH558 |
| B | HOH564 |
Functional Information from PROSITE/UniProt
| site_id | PS00348 |
| Number of Residues | 13 |
| Details | P53 p53 family signature. MCNSSCMGGMNRR |
| Chain | Residue | Details |
| A | MET237-ARG249 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 380 |
| Details | DNA binding: {"evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 246 |
| Details | Region: {"description":"Required for interaction with FBXO42","evidences":[{"source":"PubMed","id":"19509332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 352 |
| Details | Region: {"description":"Interaction with AXIN1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Region: {"description":"Interaction with the 53BP2 SH3 domain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Region: {"description":"Interaction with DNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14534297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17015838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19515728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20142040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38653238","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19536131","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
