Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | methyltransferase cap1 activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAM A 1001 |
| Chain | Residue |
| A | SER62 |
| A | HIS116 |
| A | GLU117 |
| A | VAL136 |
| A | ASP137 |
| A | VAL138 |
| A | PHE139 |
| A | ASP152 |
| A | HOH1109 |
| A | HOH1125 |
| A | HOH1128 |
| A | GLY64 |
| A | HOH1177 |
| A | GLY87 |
| A | CYS88 |
| A | GLY89 |
| A | GLY92 |
| A | TRP93 |
| A | THR110 |
| A | LYS111 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1002 |
| Chain | Residue |
| A | ARG43 |
| A | ARG47 |
| A | SER62 |
| A | ARG63 |
| A | ARG90 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1003 |
| Chain | Residue |
| A | PRO256 |
| A | VAL257 |
| A | TYR259 |
| B | TYR31 |
| B | LYS237 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 1101 |
| Chain | Residue |
| A | ARG74 |
| A | LYS258 |
| A | HOH1104 |
| B | ARG249 |
| B | ARG255 |
| B | HOH1250 |
| B | HOH1322 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 1102 |
| Chain | Residue |
| B | HIS116 |
| B | GLU117 |
| B | ARG206 |
| B | GOL1103 |
| B | HOH1223 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 1103 |
| Chain | Residue |
| B | GLY87 |
| B | THR110 |
| B | LYS111 |
| B | SO41102 |
| B | HOH1245 |
| B | HOH1299 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 1104 |
| Chain | Residue |
| B | ARG74 |
| B | HOH1278 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"SUMO-interacting motif (SIM)","evidences":[{"source":"UniProtKB","id":"A0A024B7W1","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with host SCRIB","evidences":[{"source":"UniProtKB","id":"Q01299","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"UniProtKB","id":"Q6YMS4","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"A0A024B7W1","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Site: {"description":"mRNA cap binding; via carbonyl oxygen","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]} |
