5M47

Crystal structure of DapF from Corynebacterium glutamicum in complex with D,L-diaminopimelate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008837	molecular_function	diaminopimelate epimerase activity
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016853	molecular_function	isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue API A 301

Chain	Residue
A	ASN15
A	ARG213
A	CYS221
A	GLY222
A	THR223
A	ASN74
A	ALA80
A	CYS83
A	GLY84
A	ASN85
A	ASN159
A	ASN194
A	GLU212

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Functional Information from PROSITE/UniProt

site_id	PS01326
Number of Residues	15
Details	DAP_EPIMERASE Diaminopimelate epimerase signature. NaDGSlaemCGNGvR

Chain	Residue	Details
A	ASN74-ARG88

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|Ref.4, ECO:0007744|PDB:5M47

Chain	Residue	Details
A	CYS83

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00197

Chain	Residue	Details
A	CYS221

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|Ref.4, ECO:0007744|PDB:5M47

Chain	Residue	Details
A	ASN15
A	GLY84
A	ASN159
A	ASN194
A	GLU212
A	GLY222

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00197

Chain	Residue	Details
A	ASN74

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Could be important to modulate the pK values of the two catalytic cysteine residues => ECO:0000255|HAMAP-Rule:MF_00197

Chain	Residue	Details
A	HIS161
A	GLU212

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