5M3L

Single-particle cryo-EM using alignment by classification (ABC): the structure of Lumbricus terrestris hemoglobin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005576	cellular_component	extracellular region
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0001666	biological_process	response to hypoxia
B	0005344	molecular_function	oxygen carrier activity
B	0005506	molecular_function	iron ion binding
B	0005576	cellular_component	extracellular region
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005576	cellular_component	extracellular region
C	0005833	cellular_component	hemoglobin complex
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0005344	molecular_function	oxygen carrier activity
D	0005506	molecular_function	iron ion binding
D	0005576	cellular_component	extracellular region
D	0005833	cellular_component	hemoglobin complex
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
E	0005344	molecular_function	oxygen carrier activity
E	0005506	molecular_function	iron ion binding
E	0005576	cellular_component	extracellular region
E	0005833	cellular_component	hemoglobin complex
E	0015671	biological_process	oxygen transport
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0046872	molecular_function	metal ion binding
F	0001666	biological_process	response to hypoxia
F	0005344	molecular_function	oxygen carrier activity
F	0005506	molecular_function	iron ion binding
F	0005576	cellular_component	extracellular region
F	0005833	cellular_component	hemoglobin complex
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0046872	molecular_function	metal ion binding
G	0005344	molecular_function	oxygen carrier activity
G	0005506	molecular_function	iron ion binding
G	0005576	cellular_component	extracellular region
G	0005833	cellular_component	hemoglobin complex
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0046872	molecular_function	metal ion binding
H	0005344	molecular_function	oxygen carrier activity
H	0005506	molecular_function	iron ion binding
H	0005576	cellular_component	extracellular region
H	0005833	cellular_component	hemoglobin complex
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0046872	molecular_function	metal ion binding
I	0005344	molecular_function	oxygen carrier activity
I	0005506	molecular_function	iron ion binding
I	0005576	cellular_component	extracellular region
I	0005833	cellular_component	hemoglobin complex
I	0015671	biological_process	oxygen transport
I	0019825	molecular_function	oxygen binding
I	0020037	molecular_function	heme binding
I	0046872	molecular_function	metal ion binding
J	0001666	biological_process	response to hypoxia
J	0005344	molecular_function	oxygen carrier activity
J	0005506	molecular_function	iron ion binding
J	0005576	cellular_component	extracellular region
J	0005833	cellular_component	hemoglobin complex
J	0015671	biological_process	oxygen transport
J	0019825	molecular_function	oxygen binding
J	0020037	molecular_function	heme binding
J	0046872	molecular_function	metal ion binding
K	0005344	molecular_function	oxygen carrier activity
K	0005506	molecular_function	iron ion binding
K	0005576	cellular_component	extracellular region
K	0005833	cellular_component	hemoglobin complex
K	0015671	biological_process	oxygen transport
K	0019825	molecular_function	oxygen binding
K	0020037	molecular_function	heme binding
K	0046872	molecular_function	metal ion binding
L	0005344	molecular_function	oxygen carrier activity
L	0005506	molecular_function	iron ion binding
L	0005576	cellular_component	extracellular region
L	0005833	cellular_component	hemoglobin complex
L	0015671	biological_process	oxygen transport
L	0019825	molecular_function	oxygen binding
L	0020037	molecular_function	heme binding
L	0046872	molecular_function	metal ion binding
M	0046872	molecular_function	metal ion binding
O	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue HEM A 201

Chain	Residue
A	LEU52
A	PHE53
A	HIS69
A	HIS101
A	ARG104
A	PHE112
A	ILE115
D	HIS96
D	HEM201

---

site_id	AC2
Number of Residues	10
Details	binding site for residue HEM B 201

Chain	Residue
B	PHE48
B	ARG67
B	LEU72
B	LEU92
B	HIS96
B	ARG99
B	PHE106
B	PHE109
B	GLU138
C	HIS97

---

site_id	AC3
Number of Residues	12
Details	binding site for residue HEM C 201

Chain	Residue
B	HIS91
C	LEU43
C	ARG56
C	VAL57
C	ARG73
C	ILE74
C	GLN101
C	HIS102
C	ARG105
C	HIS112
C	PHE113
C	PHE116

---

site_id	AC4
Number of Residues	8
Details	binding site for residue HEM D 201

Chain	Residue
A	HIS96
A	HEM201
D	PHE53
D	ARG72
D	LEU97
D	HIS101
D	ARG104
D	PHE114

---

site_id	AC5
Number of Residues	10
Details	binding site for residue HEM E 201

Chain	Residue
E	LEU52
E	PHE53
E	ARG55
E	HIS69
E	HIS101
E	ARG104
E	PHE112
E	ILE115
H	HIS96
H	HEM201

---

site_id	AC6
Number of Residues	9
Details	binding site for residue HEM F 201

Chain	Residue
F	PHE48
F	ARG67
F	LEU72
F	GLN95
F	HIS96
F	ARG99
F	PHE109
G	HIS97
G	GLN101

---

site_id	AC7
Number of Residues	12
Details	binding site for residue HEM G 201

Chain	Residue
F	HIS91
G	LEU43
G	VAL57
G	HIS70
G	ARG73
G	ILE74
G	LEU98
G	HIS102
G	ARG105
G	HIS112
G	PHE113
G	PHE116

---

site_id	AC8
Number of Residues	9
Details	binding site for residue HEM H 201

Chain	Residue
E	HIS96
E	HEM201
H	PHE53
H	ARG55
H	HIS69
H	ARG72
H	HIS101
H	ARG104
H	PHE114

---

site_id	AC9
Number of Residues	10
Details	binding site for residue HEM I 201

Chain	Residue
I	LEU52
I	PHE53
I	ARG55
I	HIS69
I	HIS101
I	ARG104
I	PHE112
I	ILE115
L	HIS96
L	HEM201

---

site_id	AD1
Number of Residues	9
Details	binding site for residue HEM J 201

Chain	Residue
J	PHE48
J	ARG67
J	LEU72
J	HIS96
J	ARG99
J	TYR105
J	PHE106
J	PHE109
K	HIS97

---

site_id	AD2
Number of Residues	11
Details	binding site for residue HEM K 201

Chain	Residue
K	LEU43
K	VAL57
K	HIS70
K	ARG73
K	ILE74
K	HIS102
K	ARG105
K	HIS112
K	PHE113
K	PHE116
J	HIS91

---

site_id	AD3
Number of Residues	9
Details	binding site for residue HEM L 201

Chain	Residue
I	HIS96
I	HEM201
L	PHE53
L	ARG55
L	HIS69
L	ARG72
L	LEU97
L	HIS101
L	PHE114

---

Functional Information from PROSITE/UniProt

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIsklfv.CDghnDCrng.EDEkd...C

Chain	Residue	Details
O	CYS76-CYS98
N	CYS76-CYS100
M	CYS76-CYS100

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: proximal binding residue

Chain	Residue	Details
C	HIS102
G	HIS102
K	HIS102

---