5M2Z
Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0039694 | biological_process | viral RNA genome replication |
B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0032259 | biological_process | methylation |
B | 0039694 | biological_process | viral RNA genome replication |
C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
C | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0032259 | biological_process | methylation |
C | 0039694 | biological_process | viral RNA genome replication |
D | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
D | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0008168 | molecular_function | methyltransferase activity |
D | 0032259 | biological_process | methylation |
D | 0039694 | biological_process | viral RNA genome replication |
E | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
E | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
E | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0008168 | molecular_function | methyltransferase activity |
E | 0032259 | biological_process | methylation |
E | 0039694 | biological_process | viral RNA genome replication |
F | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
F | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
F | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0008168 | molecular_function | methyltransferase activity |
F | 0032259 | biological_process | methylation |
F | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | binding site for residue PO4 A 1001 |
Chain | Residue |
A | ARG213 |
B | LYS45 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue PO4 A 1002 |
Chain | Residue |
A | LYS359 |
A | ARG473 |
A | LYS691 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue PO4 A 1003 |
Chain | Residue |
A | SER712 |
A | ARG731 |
A | ARG739 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1004 |
Chain | Residue |
A | ASN716 |
A | CYS730 |
A | CYS849 |
A | HIS714 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1005 |
Chain | Residue |
A | GLU439 |
A | HIS443 |
A | CYS448 |
A | CYS451 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue PO4 C 1001 |
Chain | Residue |
C | ARG41 |
C | ARG213 |
C | PO41002 |
D | LYS45 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue PO4 C 1002 |
Chain | Residue |
C | ARG41 |
C | ARG57 |
C | ARG84 |
C | PO41001 |
site_id | AC8 |
Number of Residues | 10 |
Details | binding site for residue SAH C 1003 |
Chain | Residue |
C | SER56 |
C | GLY58 |
C | GLY81 |
C | CYS82 |
C | GLY86 |
C | TRP87 |
C | THR104 |
C | LYS105 |
C | HIS110 |
C | ASP146 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ZN C 1004 |
Chain | Residue |
C | HIS714 |
C | ASN716 |
C | CYS730 |
C | CYS849 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue PO4 B 1001 |
Chain | Residue |
A | LYS45 |
B | ARG37 |
B | ARG57 |
B | ARG213 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue PO4 B 1002 |
Chain | Residue |
B | SER712 |
B | ARG731 |
B | ARG739 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue PO4 B 1003 |
Chain | Residue |
A | LYS29 |
A | GLU34 |
A | ARG41 |
A | ARG57 |
B | ARG42 |
B | LYS45 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1004 |
Chain | Residue |
B | HIS714 |
B | ASN716 |
B | CYS730 |
B | CYS849 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue ZN B 1005 |
Chain | Residue |
B | GLU439 |
B | HIS443 |
B | CYS448 |
B | CYS451 |
B | THR573 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue PO4 D 1001 |
Chain | Residue |
D | SER712 |
D | ARG731 |
D | ARG739 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue PO4 D 1002 |
Chain | Residue |
C | LYS45 |
D | ARG41 |
D | ARG57 |
D | ARG213 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue ZN D 1003 |
Chain | Residue |
D | HIS714 |
D | ASN716 |
D | CYS730 |
D | CYS849 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue ZN D 1004 |
Chain | Residue |
D | GLU439 |
D | HIS443 |
D | CYS448 |
D | CYS451 |
site_id | AE1 |
Number of Residues | 3 |
Details | binding site for residue PO4 E 1001 |
Chain | Residue |
E | ARG57 |
E | ARG213 |
F | LYS45 |
site_id | AE2 |
Number of Residues | 3 |
Details | binding site for residue PO4 E 1002 |
Chain | Residue |
E | SER712 |
E | ARG731 |
E | ARG739 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue PO4 E 1003 |
Chain | Residue |
E | ARG473 |
E | THR536 |
E | GLY538 |
E | LYS691 |
site_id | AE4 |
Number of Residues | 11 |
Details | binding site for residue SAH E 1005 |
Chain | Residue |
E | SER56 |
E | GLY81 |
E | CYS82 |
E | GLY86 |
E | TRP87 |
E | THR104 |
E | LYS105 |
E | HIS110 |
E | VAL130 |
E | VAL132 |
E | ASP146 |
site_id | AE5 |
Number of Residues | 4 |
Details | binding site for residue ZN E 1006 |
Chain | Residue |
E | CYS849 |
E | HIS714 |
E | ASN716 |
E | CYS730 |
site_id | AE6 |
Number of Residues | 4 |
Details | binding site for residue ZN E 1007 |
Chain | Residue |
E | GLU439 |
E | HIS443 |
E | CYS448 |
E | CYS451 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue PO4 F 1001 |
Chain | Residue |
E | LYS45 |
F | ARG41 |
F | ARG213 |
site_id | AE8 |
Number of Residues | 3 |
Details | binding site for residue PO4 F 1002 |
Chain | Residue |
F | LYS462 |
F | SER712 |
F | ARG739 |
site_id | AE9 |
Number of Residues | 3 |
Details | binding site for residue PO4 F 1003 |
Chain | Residue |
F | LYS359 |
F | ARG473 |
F | LYS691 |
site_id | AF1 |
Number of Residues | 13 |
Details | binding site for residue SAH F 1004 |
Chain | Residue |
F | SER56 |
F | GLY58 |
F | GLY81 |
F | CYS82 |
F | GLY86 |
F | TRP87 |
F | THR104 |
F | LYS105 |
F | HIS110 |
F | VAL130 |
F | VAL132 |
F | PHE133 |
F | ASP146 |
site_id | AF2 |
Number of Residues | 4 |
Details | binding site for residue ZN F 1005 |
Chain | Residue |
F | HIS714 |
F | ASN716 |
F | CYS730 |
F | CYS849 |
site_id | AF3 |
Number of Residues | 4 |
Details | binding site for residue ZN F 1006 |
Chain | Residue |
F | GLU439 |
F | HIS443 |
F | CYS448 |
F | CYS451 |
site_id | AF4 |
Number of Residues | 7 |
Details | binding site for Di-peptide PO4 E 1004 and LYS E 76 |
Chain | Residue |
E | TYR74 |
E | GLY75 |
E | VAL77 |
E | GLU99 |
E | LYS101 |
E | ASP141 |
E | THR142 |