5M0I

Crystal structure of the nuclear complex with She2p and the ASH1 mRNA E3-localization element

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005934	cellular_component	cellular bud tip
A	0007533	biological_process	mating type switching
A	0008289	molecular_function	lipid binding
A	0008298	biological_process	intracellular mRNA localization
A	0051028	biological_process	mRNA transport
A	1990825	molecular_function	sequence-specific mRNA binding
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005934	cellular_component	cellular bud tip
B	0007533	biological_process	mating type switching
B	0008289	molecular_function	lipid binding
B	0008298	biological_process	intracellular mRNA localization
B	0051028	biological_process	mRNA transport
B	1990825	molecular_function	sequence-specific mRNA binding
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005934	cellular_component	cellular bud tip
C	0007533	biological_process	mating type switching
C	0008289	molecular_function	lipid binding
C	0008298	biological_process	intracellular mRNA localization
C	0051028	biological_process	mRNA transport
C	1990825	molecular_function	sequence-specific mRNA binding
D	0003723	molecular_function	RNA binding
D	0003729	molecular_function	mRNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005934	cellular_component	cellular bud tip
D	0007533	biological_process	mating type switching
D	0008289	molecular_function	lipid binding
D	0008298	biological_process	intracellular mRNA localization
D	0051028	biological_process	mRNA transport
D	1990825	molecular_function	sequence-specific mRNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO D 301

Chain	Residue
D	GLN156
D	ILE159
D	LEU169
D	LEU171
D	VAL174

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO D 302

Chain	Residue
D	TYR148
D	HOH403
D	ASP111
D	ASN114
D	TYR115
D	ASP145

---

site_id	AC3
Number of Residues	1
Details	binding site for residue MG D 303

Chain	Residue
D	GLU124

---

site_id	AC4
Number of Residues	2
Details	binding site for residue ACT D 304

Chain	Residue
D	ASP170
D	GLN175

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO C 301

Chain	Residue
C	GLU172
C	GLN175
C	PHE176

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO C 302

Chain	Residue
C	SER166
C	ASP170
C	GLN175

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO C 303

Chain	Residue
C	ILE56
C	LYS60
D	TYR115

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO C 304

Chain	Residue
C	ILE159
C	LEU169
C	ASP170
C	LEU171
C	VAL174

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO C 305

Chain	Residue
C	ASP111
C	ASN114
C	ASP145
C	TYR148
C	HOH404

---

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO C 306

Chain	Residue
C	SER101
C	MET102
C	LYS105
D	SER101
D	LEU168
D	LEU169

---

site_id	AD2
Number of Residues	1
Details	binding site for residue MG C 307

Chain	Residue
C	TYR116

---

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO B 301

Chain	Residue
B	ASP111
B	ASN114
B	TYR115
B	ASP145
B	TYR148
B	HOH419

---

site_id	AD4
Number of Residues	3
Details	binding site for residue ACT B 303

Chain	Residue
B	THR129
B	ASN131
B	LEU134

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO A 301

Chain	Residue
A	ASP170
A	GLN175
A	LYS179
B	PHE64
B	SER68

---

site_id	AD6
Number of Residues	1
Details	binding site for residue EDO E 101

Chain	Residue
E	U7

---

site_id	AD7
Number of Residues	3
Details	binding site for residue ACT E 102

Chain	Residue
E	A9
E	A10
E	HOH228

---

site_id	AD8
Number of Residues	3
Details	binding site for residue ACT E 103

Chain	Residue
E	A5
E	A20
E	HOH240

---

site_id	AD9
Number of Residues	3
Details	binding site for residue ACT E 104

Chain	Residue
E	G13
E	A15
E	A16

---

site_id	AE1
Number of Residues	4
Details	binding site for residue MG F 101

Chain	Residue
F	C6
F	U7
F	HOH227
F	HOH236

---

site_id	AE2
Number of Residues	3
Details	binding site for residue MG F 102

Chain	Residue
C	HOH448
F	U7
F	G8

---

site_id	AE3
Number of Residues	2
Details	binding site for residue ACT F 103

Chain	Residue
F	A5
F	A20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Motif: {"description":"Nuclear localization signal"}

Chain

Residue

Details

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