Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LZG

Cholera toxin El Tor B-pentamer in complex with inhibitor PC262

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005534	molecular_function	galactose binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0020002	cellular_component	host cell plasma membrane
A	0035821	biological_process	modulation of process of another organism
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0042597	cellular_component	periplasmic space
A	0046812	molecular_function	host cell surface binding
A	0090729	molecular_function	toxin activity
A	1902494	cellular_component	catalytic complex
B	0005515	molecular_function	protein binding
B	0005534	molecular_function	galactose binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0020002	cellular_component	host cell plasma membrane
B	0035821	biological_process	modulation of process of another organism
B	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
B	0042597	cellular_component	periplasmic space
B	0046812	molecular_function	host cell surface binding
B	0090729	molecular_function	toxin activity
B	1902494	cellular_component	catalytic complex
C	0005515	molecular_function	protein binding
C	0005534	molecular_function	galactose binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0020002	cellular_component	host cell plasma membrane
C	0035821	biological_process	modulation of process of another organism
C	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
C	0042597	cellular_component	periplasmic space
C	0046812	molecular_function	host cell surface binding
C	0090729	molecular_function	toxin activity
C	1902494	cellular_component	catalytic complex
D	0005515	molecular_function	protein binding
D	0005534	molecular_function	galactose binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0020002	cellular_component	host cell plasma membrane
D	0035821	biological_process	modulation of process of another organism
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0042597	cellular_component	periplasmic space
D	0046812	molecular_function	host cell surface binding
D	0090729	molecular_function	toxin activity
D	1902494	cellular_component	catalytic complex
E	0005515	molecular_function	protein binding
E	0005534	molecular_function	galactose binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0020002	cellular_component	host cell plasma membrane
E	0035821	biological_process	modulation of process of another organism
E	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
E	0042597	cellular_component	periplasmic space
E	0046812	molecular_function	host cell surface binding
E	0090729	molecular_function	toxin activity
E	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue 7BN A 201

Chain	Residue
A	GLU11
A	ASN90
A	LYS91
A	IMD203
A	HOH323
A	HOH339
A	HOH346
A	HOH348
A	HOH350
A	HOH356
A	HOH357
A	TYR12
A	HOH366
A	HOH375
B	GLY33
B	LYS34
C	HOH314
A	HIS13
A	GLU51
A	GLN56
A	HIS57
A	ILE58
A	GLN61
A	TRP88

site_id	AC2
Number of Residues	8
Details	binding site for residue TRS A 202

Chain	Residue
A	TYR76
A	LEU77
A	GLU79
A	HOH304
A	HOH314
E	THR78
E	GLU79
E	ALA80

site_id	AC3
Number of Residues	3
Details	binding site for residue IMD A 203

Chain	Residue
A	ALA10
A	GLU11
A	7BN201

site_id	AC4
Number of Residues	20
Details	binding site for residue 7BN B 201

Chain	Residue
B	GLU11
B	TYR12
B	HIS13
B	GLU51
B	GLN56
B	HIS57
B	ILE58
B	GLN61
B	TRP88
B	ASN90
B	LYS91
B	HOH308
B	HOH309
B	HOH316
B	HOH331
B	HOH339
B	HOH345
B	HOH373
C	GLY33
C	HOH362

site_id	AC5
Number of Residues	26
Details	binding site for residue 7BN C 201

Chain	Residue
C	GLU11
C	TYR12
C	HIS13
C	GLU51
C	GLN56
C	HIS57
C	ILE58
C	GLN61
C	TRP88
C	ASN90
C	LYS91
C	PEG202
C	HOH312
C	HOH316
C	HOH319
C	HOH330
C	HOH335
C	HOH337
C	HOH346
C	HOH353
C	HOH364
C	HOH368
C	HOH386
D	GLY33
D	HOH373
E	TYR18

site_id	AC6
Number of Residues	5
Details	binding site for residue PEG C 202

Chain	Residue
C	ALA10
C	GLU11
C	TYR12
C	HIS13
C	7BN201

site_id	AC7
Number of Residues	23
Details	binding site for residue 7BN D 201

Chain	Residue
D	HOH322
D	HOH324
D	HOH325
D	HOH329
D	HOH335
D	HOH350
D	HOH351
D	HOH372
E	GLY33
E	HOH373
A	TYR18
D	GLU11
D	TYR12
D	HIS13
D	GLU51
D	GLN56
D	ILE58
D	GLN61
D	TRP88
D	ASN90
D	LYS91
D	HOH305
D	HOH308

site_id	AC8
Number of Residues	4
Details	binding site for residue IMD D 202

Chain	Residue
B	HIS13
D	ALA10
D	HIS13
D	HOH354

site_id	AC9
Number of Residues	23
Details	binding site for residue 7BN E 201

Chain	Residue
A	GLY33
A	LYS34
E	GLU11
E	TYR12
E	HIS13
E	GLU51
E	GLN56
E	HIS57
E	ILE58
E	GLN61
E	TRP88
E	ASN90
E	LYS91
E	HOH301
E	HOH303
E	HOH306
E	HOH309
E	HOH312
E	HOH321
E	HOH326
E	HOH360
E	HOH372
E	HOH393

site_id	AD1
Number of Residues	3
Details	binding site for residue MRD E 202

Chain	Residue
E	LEU77
E	HOH305
E	HOH331

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)