5LZG
Cholera toxin El Tor B-pentamer in complex with inhibitor PC262
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005534 | molecular_function | galactose binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0042531 | biological_process | positive regulation of tyrosine phosphorylation of STAT protein |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046812 | molecular_function | host cell surface binding |
| A | 1902494 | cellular_component | catalytic complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005534 | molecular_function | galactose binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0042531 | biological_process | positive regulation of tyrosine phosphorylation of STAT protein |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046812 | molecular_function | host cell surface binding |
| B | 1902494 | cellular_component | catalytic complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005534 | molecular_function | galactose binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0020002 | cellular_component | host cell plasma membrane |
| C | 0042531 | biological_process | positive regulation of tyrosine phosphorylation of STAT protein |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0046812 | molecular_function | host cell surface binding |
| C | 1902494 | cellular_component | catalytic complex |
| D | 0005515 | molecular_function | protein binding |
| D | 0005534 | molecular_function | galactose binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0020002 | cellular_component | host cell plasma membrane |
| D | 0042531 | biological_process | positive regulation of tyrosine phosphorylation of STAT protein |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0046812 | molecular_function | host cell surface binding |
| D | 1902494 | cellular_component | catalytic complex |
| E | 0005515 | molecular_function | protein binding |
| E | 0005534 | molecular_function | galactose binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0020002 | cellular_component | host cell plasma membrane |
| E | 0042531 | biological_process | positive regulation of tyrosine phosphorylation of STAT protein |
| E | 0042597 | cellular_component | periplasmic space |
| E | 0046812 | molecular_function | host cell surface binding |
| E | 1902494 | cellular_component | catalytic complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue 7BN A 201 |
| Chain | Residue |
| A | GLU11 |
| A | ASN90 |
| A | LYS91 |
| A | IMD203 |
| A | HOH323 |
| A | HOH339 |
| A | HOH346 |
| A | HOH348 |
| A | HOH350 |
| A | HOH356 |
| A | HOH357 |
| A | TYR12 |
| A | HOH366 |
| A | HOH375 |
| B | GLY33 |
| B | LYS34 |
| C | HOH314 |
| A | HIS13 |
| A | GLU51 |
| A | GLN56 |
| A | HIS57 |
| A | ILE58 |
| A | GLN61 |
| A | TRP88 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue TRS A 202 |
| Chain | Residue |
| A | TYR76 |
| A | LEU77 |
| A | GLU79 |
| A | HOH304 |
| A | HOH314 |
| E | THR78 |
| E | GLU79 |
| E | ALA80 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue IMD A 203 |
| Chain | Residue |
| A | ALA10 |
| A | GLU11 |
| A | 7BN201 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue 7BN B 201 |
| Chain | Residue |
| B | GLU11 |
| B | TYR12 |
| B | HIS13 |
| B | GLU51 |
| B | GLN56 |
| B | HIS57 |
| B | ILE58 |
| B | GLN61 |
| B | TRP88 |
| B | ASN90 |
| B | LYS91 |
| B | HOH308 |
| B | HOH309 |
| B | HOH316 |
| B | HOH331 |
| B | HOH339 |
| B | HOH345 |
| B | HOH373 |
| C | GLY33 |
| C | HOH362 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | binding site for residue 7BN C 201 |
| Chain | Residue |
| C | GLU11 |
| C | TYR12 |
| C | HIS13 |
| C | GLU51 |
| C | GLN56 |
| C | HIS57 |
| C | ILE58 |
| C | GLN61 |
| C | TRP88 |
| C | ASN90 |
| C | LYS91 |
| C | PEG202 |
| C | HOH312 |
| C | HOH316 |
| C | HOH319 |
| C | HOH330 |
| C | HOH335 |
| C | HOH337 |
| C | HOH346 |
| C | HOH353 |
| C | HOH364 |
| C | HOH368 |
| C | HOH386 |
| D | GLY33 |
| D | HOH373 |
| E | TYR18 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue PEG C 202 |
| Chain | Residue |
| C | ALA10 |
| C | GLU11 |
| C | TYR12 |
| C | HIS13 |
| C | 7BN201 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue 7BN D 201 |
| Chain | Residue |
| D | HOH322 |
| D | HOH324 |
| D | HOH325 |
| D | HOH329 |
| D | HOH335 |
| D | HOH350 |
| D | HOH351 |
| D | HOH372 |
| E | GLY33 |
| E | HOH373 |
| A | TYR18 |
| D | GLU11 |
| D | TYR12 |
| D | HIS13 |
| D | GLU51 |
| D | GLN56 |
| D | ILE58 |
| D | GLN61 |
| D | TRP88 |
| D | ASN90 |
| D | LYS91 |
| D | HOH305 |
| D | HOH308 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue IMD D 202 |
| Chain | Residue |
| B | HIS13 |
| D | ALA10 |
| D | HIS13 |
| D | HOH354 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | binding site for residue 7BN E 201 |
| Chain | Residue |
| A | GLY33 |
| A | LYS34 |
| E | GLU11 |
| E | TYR12 |
| E | HIS13 |
| E | GLU51 |
| E | GLN56 |
| E | HIS57 |
| E | ILE58 |
| E | GLN61 |
| E | TRP88 |
| E | ASN90 |
| E | LYS91 |
| E | HOH301 |
| E | HOH303 |
| E | HOH306 |
| E | HOH309 |
| E | HOH312 |
| E | HOH321 |
| E | HOH326 |
| E | HOH360 |
| E | HOH372 |
| E | HOH393 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue MRD E 202 |
| Chain | Residue |
| E | LEU77 |
| E | HOH305 |
| E | HOH331 |
