5LX9

CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID AT 2.4 ANGSTROM RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS202
A	HIS348
A	HIS352
A	OLA402
A	HOH506

---

site_id	AC2
Number of Residues	11
Details	binding site for residue OLA A 402

Chain	Residue
A	TYR321
A	TYR328
A	HIS348
A	PHE351
A	PHE354
A	GLY358
A	ZN401
A	ASP219
A	TYR220
A	ILE223
A	PHE282

---

site_id	AC3
Number of Residues	9
Details	binding site for residue OLB A 403

Chain	Residue
A	SER196
A	PHE197
A	LEU200
A	LEU214
A	OLB408
A	HOH519
A	HOH539
H	OLB301
H	OLB302

---

site_id	AC4
Number of Residues	5
Details	binding site for residue OLB A 404

Chain	Residue
A	SER230
A	GLY286
A	MET317
A	TYR321
A	HIS362

---

site_id	AC5
Number of Residues	6
Details	binding site for residue OLB A 405

Chain	Residue
A	PHE168
A	TYR274
A	GLY280
A	LEU287
A	OLB406
A	OLB412

---

site_id	AC6
Number of Residues	11
Details	binding site for residue OLB A 406

Chain	Residue
A	GLY163
A	MET167
A	PHE168
A	ARG169
A	PRO170
A	ASN171
A	GLY276
A	ILE322
A	OLB405
A	OLB411
A	HOH544

---

site_id	AC7
Number of Residues	6
Details	binding site for residue OLB A 407

Chain	Residue
A	VAL157
A	PHE158
A	CYS161
A	PHE165
A	HOH525
A	HOH662

---

site_id	AC8
Number of Residues	4
Details	binding site for residue OLB A 408

Chain	Residue
A	LEU153
A	CYS156
A	OLB403
H	OLB301

---

site_id	AC9
Number of Residues	4
Details	binding site for residue OLB A 409

Chain	Residue
A	LEU214
A	LEU218
A	LEU225
A	GLN265

---

site_id	AD1
Number of Residues	4
Details	binding site for residue OLB A 410

Chain	Residue
A	GLN179
A	VAL232
A	TYR236
A	TYR240

---

site_id	AD2
Number of Residues	7
Details	binding site for residue OLB A 411

Chain	Residue
A	ASN171
A	LEU186
A	GLN273
A	GLY276
A	ALA329
A	ARG335
A	OLB406

---

site_id	AD3
Number of Residues	4
Details	binding site for residue OLB A 412

Chain	Residue
A	TYR274
A	GLY284
A	LEU285
A	OLB405

---

site_id	AD4
Number of Residues	16
Details	binding site for residue OLB H 301

Chain	Residue
A	SER131
A	PHE132
A	ARG133
A	PHE136
A	VAL297
A	GLY301
A	PHE302
A	LEU303
A	OLB403
A	OLB408
H	ASN167
H	HIS169
H	ASN170
H	GLY207
H	OLB302
H	HOH476

---

site_id	AD5
Number of Residues	7
Details	binding site for residue OLB H 302

Chain	Residue
A	PHE132
A	GLY210
A	PHE302
A	OLB403
A	HOH504
H	LYS191
H	OLB301

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GGS..EFEGRWRVI

Chain	Residue	Details
A	GLY-4-ILE106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	33
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25855295","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---