5LUG

Crystal structure of human Spindlin-2B protein in complex with ART(M3L)QTA(2MR)KS peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007276	biological_process	gamete generation
B	0007276	biological_process	gamete generation
C	0007276	biological_process	gamete generation
D	0007276	biological_process	gamete generation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 301

Chain	Residue
A	GLU146
A	TRP147
A	LYS168
A	HOH426
A	HOH466

---

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 302

Chain	Residue
A	ASP180
A	ASP185

---

site_id	AC3
Number of Residues	6
Details	binding site for residue 2MR B 301

Chain	Residue
B	ILE90
B	TYR94
B	HOH421
E	ALA7
B	TRP68
B	TYR87

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO B 302

Chain	Residue
B	GLU146
B	TRP147
B	LYS168
B	HOH430
B	HOH479

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO B 303

Chain	Residue
B	GLU138
B	GLY139
B	GLY142
B	SER143
D	HOH478
D	HOH572

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO B 304

Chain	Residue
B	ASP180
B	ASP185

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO D 301

Chain	Residue
D	ASN79
D	GLU97
D	LYS242
D	ASP244
D	HOH429

---

site_id	AC8
Number of Residues	14
Details	binding site for Ligand residues M3L E 4 through GLN E 5 bound to THR E 3

Chain	Residue
B	GLY89
B	ILE90
B	ASP91
B	PHE137
B	TRP147
B	TYR166
B	ASP169
B	TYR175
B	HOH439
B	HOH448
E	THR3
E	THR6
E	HOH101
E	HOH106

---

site_id	AC9
Number of Residues	13
Details	binding site for Ligand residues M3L F 4 through GLN F 5 bound to THR F 3

Chain	Residue
A	GLY89
A	ILE90
A	ASP91
A	PHE137
A	TRP147
A	TYR166
A	ASP169
A	TYR175
A	HOH410
A	HOH478
F	THR3
F	THR6
F	HOH102

---

site_id	AD1
Number of Residues	19
Details	binding site for Ligand residues M3L G 4 through GLN G 5 bound to THR G 3

Chain	Residue
B	HIS141
B	SER143
D	GLY89
D	ILE90
D	ASP91
D	PHE137
D	ASP145
D	TRP147
D	TYR166
D	ASP169
D	TYR173
D	TYR175
D	HOH423
G	THR3
G	THR6
G	HOH102
G	HOH105
G	HOH107
G	HOH109

---

site_id	AD2
Number of Residues	19
Details	binding site for Ligand residues M3L H 4 through GLN H 5 bound to THR H 3

Chain	Residue
A	HIS141
A	SER143
A	HOH483
C	GLY89
C	ILE90
C	ASP91
C	PHE137
C	ASP145
C	TRP147
C	TYR166
C	ASP169
C	TYR173
C	TYR175
C	HOH336
H	THR3
H	THR6
H	HOH103
H	HOH106
H	HOH107

---

site_id	AD3
Number of Residues	6
Details	binding site for Di-peptide ALA F 7 and 2MR F 8

Chain	Residue
A	TYR94
F	THR6
F	HOH103
A	TRP68
A	TYR87
A	ILE90

---

site_id	AD4
Number of Residues	7
Details	binding site for Di-peptide ALA G 7 and 2MR G 8

Chain	Residue
B	HOH589
D	TRP68
D	ILE90
D	TYR94
D	HOH490
G	THR6
G	HOH101

---

site_id	AD5
Number of Residues	7
Details	binding site for Di-peptide ALA H 7 and 2MR H 8

Chain	Residue
A	HOH451
C	TRP68
C	TYR87
C	ILE90
C	TYR94
H	THR6
H	HOH101

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
F	ARG2
D	ASP169
D	GLN176
D	ASP180
G	ARG2
H	ARG2
E	ARG2
B	GLN176
B	ASP180
C	ASP169
C	GLN176
C	ASP180

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692

Chain	Residue	Details
F	THR3
G	THR3
H	THR3
E	THR3

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
F	M3L4
G	M3L4
H	M3L4
E	M3L4

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
F	GLN5
G	GLN5
H	GLN5
E	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
F	THR6
G	THR6
H	THR6
E	THR6

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
F	2MR8
G	2MR8
H	2MR8
E	2MR8

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
F	LYS9
G	LYS9
H	LYS9
E	LYS9

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588

Chain	Residue	Details
F	SER10
G	SER10
H	SER10
E	SER10

---