5LUG

Crystal structure of human Spindlin-2B protein in complex with ART(M3L)QTA(2MR)KS peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007276	biological_process	gamete generation
B	0007276	biological_process	gamete generation
C	0007276	biological_process	gamete generation
D	0007276	biological_process	gamete generation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 301

Chain	Residue
A	GLU146
A	TRP147
A	LYS168
A	HOH426
A	HOH466

---

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 302

Chain	Residue
A	ASP180
A	ASP185

---

site_id	AC3
Number of Residues	6
Details	binding site for residue 2MR B 301

Chain	Residue
B	ILE90
B	TYR94
B	HOH421
E	ALA7
B	TRP68
B	TYR87

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO B 302

Chain	Residue
B	GLU146
B	TRP147
B	LYS168
B	HOH430
B	HOH479

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO B 303

Chain	Residue
B	GLU138
B	GLY139
B	GLY142
B	SER143
D	HOH478
D	HOH572

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO B 304

Chain	Residue
B	ASP180
B	ASP185

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO D 301

Chain	Residue
D	ASN79
D	GLU97
D	LYS242
D	ASP244
D	HOH429

---

site_id	AC8
Number of Residues	14
Details	binding site for Ligand residues M3L E 4 through GLN E 5 bound to THR E 3

Chain	Residue
B	GLY89
B	ILE90
B	ASP91
B	PHE137
B	TRP147
B	TYR166
B	ASP169
B	TYR175
B	HOH439
B	HOH448
E	THR3
E	THR6
E	HOH101
E	HOH106

---

site_id	AC9
Number of Residues	13
Details	binding site for Ligand residues M3L F 4 through GLN F 5 bound to THR F 3

Chain	Residue
A	GLY89
A	ILE90
A	ASP91
A	PHE137
A	TRP147
A	TYR166
A	ASP169
A	TYR175
A	HOH410
A	HOH478
F	THR3
F	THR6
F	HOH102

---

site_id	AD1
Number of Residues	19
Details	binding site for Ligand residues M3L G 4 through GLN G 5 bound to THR G 3

Chain	Residue
B	HIS141
B	SER143
D	GLY89
D	ILE90
D	ASP91
D	PHE137
D	ASP145
D	TRP147
D	TYR166
D	ASP169
D	TYR173
D	TYR175
D	HOH423
G	THR3
G	THR6
G	HOH102
G	HOH105
G	HOH107
G	HOH109

---

site_id	AD2
Number of Residues	19
Details	binding site for Ligand residues M3L H 4 through GLN H 5 bound to THR H 3

Chain	Residue
A	HIS141
A	SER143
A	HOH483
C	GLY89
C	ILE90
C	ASP91
C	PHE137
C	ASP145
C	TRP147
C	TYR166
C	ASP169
C	TYR173
C	TYR175
C	HOH336
H	THR3
H	THR6
H	HOH103
H	HOH106
H	HOH107

---

site_id	AD3
Number of Residues	6
Details	binding site for Di-peptide ALA F 7 and 2MR F 8

Chain	Residue
A	TYR94
F	THR6
F	HOH103
A	TRP68
A	TYR87
A	ILE90

---

site_id	AD4
Number of Residues	7
Details	binding site for Di-peptide ALA G 7 and 2MR G 8

Chain	Residue
B	HOH589
D	TRP68
D	ILE90
D	TYR94
D	HOH490
G	THR6
G	HOH101

---

site_id	AD5
Number of Residues	7
Details	binding site for Di-peptide ALA H 7 and 2MR H 8

Chain	Residue
A	HOH451
C	TRP68
C	TYR87
C	ILE90
C	TYR94
H	THR6
H	HOH101

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	196
Details	Region: {"description":"Tudor-like domain 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	196
Details	Region: {"description":"Tudor-like domain 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"UniProtKB","id":"Q9Y657","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	180
Details	Region: {"description":"Tudor-like domain 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Site: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"UniProtKB","id":"Q9Y657","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---