5LU6
Heptose isomerase mutant - H64Q
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008968 | molecular_function | D-sedoheptulose 7-phosphate isomerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| A | 2001061 | biological_process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008968 | molecular_function | D-sedoheptulose 7-phosphate isomerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 2001061 | biological_process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0008968 | molecular_function | D-sedoheptulose 7-phosphate isomerase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0097367 | molecular_function | carbohydrate derivative binding |
| C | 1901135 | biological_process | carbohydrate derivative metabolic process |
| C | 2001061 | biological_process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0008968 | molecular_function | D-sedoheptulose 7-phosphate isomerase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0097367 | molecular_function | carbohydrate derivative binding |
| D | 1901135 | biological_process | carbohydrate derivative metabolic process |
| D | 2001061 | biological_process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue I22 A 201 |
| Chain | Residue |
| A | ASN55 |
| A | HOH319 |
| A | HOH354 |
| A | HOH390 |
| B | ASN97 |
| B | ASP98 |
| D | GLU68 |
| D | PHE73 |
| A | GLY56 |
| A | GLY57 |
| A | SER123 |
| A | THR124 |
| A | SER125 |
| A | SER128 |
| A | THR171 |
| A | GLN175 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 202 |
| Chain | Residue |
| A | LYS35 |
| A | ASP161 |
| A | GOL203 |
| A | HOH385 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 203 |
| Chain | Residue |
| A | THR32 |
| A | LYS35 |
| A | EDO202 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue I22 B 201 |
| Chain | Residue |
| A | ASN97 |
| A | ASP98 |
| B | ASN55 |
| B | GLY56 |
| B | GLY57 |
| B | SER123 |
| B | THR124 |
| B | SER125 |
| B | SER128 |
| B | THR171 |
| B | GLN175 |
| B | HOH306 |
| B | HOH335 |
| B | HOH336 |
| B | HOH384 |
| B | HOH390 |
| C | GLU68 |
| C | ARG72 |
| C | PHE73 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| B | ASP161 |
| B | LEU162 |
| B | LEU163 |
| B | PGE203 |
| B | HOH326 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PGE B 203 |
| Chain | Residue |
| B | ALA31 |
| B | THR32 |
| B | LYS35 |
| B | LEU162 |
| B | GOL202 |
| B | HOH310 |
| B | HOH422 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue I22 C 201 |
| Chain | Residue |
| B | GLU68 |
| B | ARG72 |
| B | PHE73 |
| C | ASN55 |
| C | GLY56 |
| C | GLY57 |
| C | SER123 |
| C | THR124 |
| C | SER125 |
| C | SER128 |
| C | THR171 |
| C | GLN175 |
| C | HOH319 |
| C | HOH325 |
| C | HOH338 |
| C | HOH359 |
| D | ASN97 |
| D | ASP98 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 202 |
| Chain | Residue |
| C | ALA14 |
| C | GLN17 |
| C | ARG18 |
| C | HOH312 |
| C | HOH331 |
| C | HOH384 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for residue I22 D 201 |
| Chain | Residue |
| A | GLU68 |
| A | ARG72 |
| A | HOH381 |
| C | ASN97 |
| C | ASP98 |
| D | ASN55 |
| D | GLY56 |
| D | GLY57 |
| D | SER123 |
| D | THR124 |
| D | SER125 |
| D | SER128 |
| D | THR171 |
| D | GLN175 |
| D | LYS196 |
| D | HOH319 |
| D | HOH328 |
| D | HOH338 |
| D | HOH342 |
| D | HOH344 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 202 |
| Chain | Residue |
| D | CYS160 |
| D | ASP161 |
| D | LEU163 |
| D | HOH312 |
| D | ARG157 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 203 |
| Chain | Residue |
| B | GLU115 |
| B | GLY142 |
| D | GLN17 |
| D | ARG18 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 204 |
| Chain | Residue |
| D | ARG157 |
| D | HOH309 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 205 |
| Chain | Residue |
| D | GLY113 |
| D | ASN114 |
| D | GLU115 |
| D | LYS141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASN55 | |
| C | ASN97 | |
| C | SER123 | |
| C | SER128 | |
| D | ASN55 | |
| D | ASN97 | |
| D | SER123 | |
| D | SER128 | |
| A | ASN97 | |
| A | SER123 | |
| A | SER128 | |
| B | ASN55 | |
| B | ASN97 | |
| B | SER123 | |
| B | SER128 | |
| C | ASN55 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20447408 |
| Chain | Residue | Details |
| A | GLN64 | |
| C | GLU68 | |
| C | GLN175 | |
| C | HIS183 | |
| D | GLN64 | |
| D | GLU68 | |
| D | GLN175 | |
| D | HIS183 | |
| A | GLU68 | |
| A | GLN175 | |
| A | HIS183 | |
| B | GLN64 | |
| B | GLU68 | |
| B | GLN175 | |
| B | HIS183 | |
| C | GLN64 |
