5LU6

Heptose isomerase mutant - H64Q

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008968	molecular_function	D-sedoheptulose 7-phosphate isomerase activity
A	0016853	molecular_function	isomerase activity
A	0045227	biological_process	capsule polysaccharide biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0097367	molecular_function	carbohydrate derivative binding
A	1901135	biological_process	carbohydrate derivative metabolic process
A	2001061	biological_process	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0008270	molecular_function	zinc ion binding
B	0008968	molecular_function	D-sedoheptulose 7-phosphate isomerase activity
B	0016853	molecular_function	isomerase activity
B	0045227	biological_process	capsule polysaccharide biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0097367	molecular_function	carbohydrate derivative binding
B	1901135	biological_process	carbohydrate derivative metabolic process
B	2001061	biological_process	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0008270	molecular_function	zinc ion binding
C	0008968	molecular_function	D-sedoheptulose 7-phosphate isomerase activity
C	0016853	molecular_function	isomerase activity
C	0045227	biological_process	capsule polysaccharide biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0097367	molecular_function	carbohydrate derivative binding
C	1901135	biological_process	carbohydrate derivative metabolic process
C	2001061	biological_process	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0008270	molecular_function	zinc ion binding
D	0008968	molecular_function	D-sedoheptulose 7-phosphate isomerase activity
D	0016853	molecular_function	isomerase activity
D	0045227	biological_process	capsule polysaccharide biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0097367	molecular_function	carbohydrate derivative binding
D	1901135	biological_process	carbohydrate derivative metabolic process
D	2001061	biological_process	D-glycero-D-manno-heptose 7-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue I22 A 201

Chain	Residue
A	ASN55
A	HOH319
A	HOH354
A	HOH390
B	ASN97
B	ASP98
D	GLU68
D	PHE73
A	GLY56
A	GLY57
A	SER123
A	THR124
A	SER125
A	SER128
A	THR171
A	GLN175

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 202

Chain	Residue
A	LYS35
A	ASP161
A	GOL203
A	HOH385

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 203

Chain	Residue
A	THR32
A	LYS35
A	EDO202

---

site_id	AC4
Number of Residues	19
Details	binding site for residue I22 B 201

Chain	Residue
A	ASN97
A	ASP98
B	ASN55
B	GLY56
B	GLY57
B	SER123
B	THR124
B	SER125
B	SER128
B	THR171
B	GLN175
B	HOH306
B	HOH335
B	HOH336
B	HOH384
B	HOH390
C	GLU68
C	ARG72
C	PHE73

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL B 202

Chain	Residue
B	ASP161
B	LEU162
B	LEU163
B	PGE203
B	HOH326

---

site_id	AC6
Number of Residues	7
Details	binding site for residue PGE B 203

Chain	Residue
B	ALA31
B	THR32
B	LYS35
B	LEU162
B	GOL202
B	HOH310
B	HOH422

---

site_id	AC7
Number of Residues	18
Details	binding site for residue I22 C 201

Chain	Residue
B	GLU68
B	ARG72
B	PHE73
C	ASN55
C	GLY56
C	GLY57
C	SER123
C	THR124
C	SER125
C	SER128
C	THR171
C	GLN175
C	HOH319
C	HOH325
C	HOH338
C	HOH359
D	ASN97
D	ASP98

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO C 202

Chain	Residue
C	ALA14
C	GLN17
C	ARG18
C	HOH312
C	HOH331
C	HOH384

---

site_id	AC9
Number of Residues	20
Details	binding site for residue I22 D 201

Chain	Residue
A	GLU68
A	ARG72
A	HOH381
C	ASN97
C	ASP98
D	ASN55
D	GLY56
D	GLY57
D	SER123
D	THR124
D	SER125
D	SER128
D	THR171
D	GLN175
D	LYS196
D	HOH319
D	HOH328
D	HOH338
D	HOH342
D	HOH344

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO D 202

Chain	Residue
D	CYS160
D	ASP161
D	LEU163
D	HOH312
D	ARG157

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO D 203

Chain	Residue
B	GLU115
B	GLY142
D	GLN17
D	ARG18

---

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO D 204

Chain	Residue
D	ARG157
D	HOH309

---

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL D 205

Chain	Residue
D	GLY113
D	ASN114
D	GLU115
D	LYS141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20447408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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